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Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors.

Abstract：

:Using a dengue replicon cell line-based screening, we identified 3-(dimethylamino)propyl(3-((4-(4-fluorophenyl)-1-oxophthalazin-2(1H)-yl)methyl)phenyl)carbamate (10a) as a potent DENV-2 inhibitor, with an IC50 value of 0.64 μM. A series of novel phthalazinone derivatives based on hit 10a were synthesized and evaluated for their in vitro anti-DENV activity and cytotoxicity. The subsequent SAR study and optimization led to the discovery of the most promising compound 14l, which displayed potent anti-DENV-2 activity, with low IC50 value against DENV-2 RNA replication of 0.13 μM and high selectivity (SI = 89.2) with acceptable pharmacokinetics profiles.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Lu D,Liu J,Zhang Y,Liu F,Zeng L,Peng R,Yang L,Ying H,Tang W,Chen W,Zuo J,Tong X,Liu T,Hu Y

doi

10.1016/j.ejmech.2018.01.008

subject

Has Abstract

pub_date

2018-02-10 00:00:00

pages

328-337

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(18)30008-4

journal_volume

145

pub_type

杂志文章

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