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Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents.

Abstract：

:The emergence of drug resistance has created unmet medical need for the development of new classes of antibiotics. Innovation of new antibacterial agents with new mode of action remains a high priority universally. Triazines are six-membered, nitrogen-containing heterocyclic scaffold with a wide range of pharmaceutical properties such as antibacterial, antifungal, anticancer, antioxidants, antitubercular, antimalarial, anti-HIV, anticonvulsant, anti-inflammatory, antiulcer, and analgesic activities. The present review focuses on the recent developments in the area of medicinal chemistry to discover various chemical structures as potential antimicrobial agents and their structure-activity relationships (SAR) studies are also discussed for further rational design of this kind of derivatives.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Liu H,Long S,Rakesh KP,Zha GF

doi

10.1016/j.ejmech.2019.111804

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

111804

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(19)30956-0

journal_volume

185

pub_type

杂志文章,评审

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