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Synthesis and antibacterial study of unsaturated Mannich ketones.

Abstract：

:Several Mannich ketones of 2-arylmethylenecycloalkanones were synthesised using the classical acid-catalysed Mannich reaction. Antibacterial activity of these new water-soluble compounds was reported against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Staphylococcus saprophyticus, Micrococcus luteus and Bacillus subtilis standard strains. Human cell line cytotoxicity of our new compounds was evaluated against HeLa cell lines. Some compounds showed low cytotoxicity (41.52 nM mL(-1) for 14 and 46.60 nM mL(-1) for 18) and proved to be efficient antibacterial agents against the Gram-positive strains. Minimum inhibitory concentrations varied from 1.56 to 100 microg mL(-1). The mechanism of action was examined, too.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Lóránd T,Kocsis B,Sohár P,Nagy G,Kispál G,Krane HG,Schmitt H,Weckert E

doi

10.1016/s0223-5234(01)01264-8

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

705-17

issue

9

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(01)01264-8

journal_volume

36

pub_type

杂志文章

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