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Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry.

Abstract：

:Based on the advantages of natural products in new anti-cancer drug development, we synthesized a series of novel benzopyran-4-one derivatives and evaluated their in vitro anti-cancer activities. The bioassays showed that the majority of the resultant compounds exerted anti-tumor effect against six human cancer cell lines to various extents, which supported the rationale of the design. Compound 5s exhibited highest potency of all the synthesized compounds.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Zhang Y,Lv Z,Zhong H,Geng D,Zhang M,Zhang T,Li Y,Li K

doi

10.1016/j.ejmech.2012.04.026

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

356-63

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(12)00278-4

journal_volume

53

pub_type

杂志文章

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