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Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides.

Abstract：

:A practicable method of introducing a side chain to the C-4' position of 5-O-desosamine in the 14-membered ketolides was developed. And using this method, a series of novel modified 5-O-mycaminose ketolides were synthesized. These ketolides containing 5-O-4'-carbamate mycaminose were evaluated for their in vitro antibacterial activities against some respiratory pathogens. 15b and 18e showed comparable activity to telithromycin and clarithromycin.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Xu Y,Chen X,Zhu D,Liu Y,Zhao Z,Jin L,Liu C,Lei P

doi

10.1016/j.ejmech.2013.08.023

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

174-81

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(13)00529-1

journal_volume

69

pub_type

杂志文章

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