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Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome.

Abstract：

:Alteration of nutritional habits play an essential role on the risk of developing Metabolic Syndrome (MetS). Several epidemiological studies have shown that assuming diets rich of foods included in the Mediterranean diet (MetDiet) pattern like, such as olive oil, nuts, fruit, fiber, vegetables, wine and grain cereals has protective effects on the different risk factors characterizing the MetS. The beneficial effects of the MetDiet in the MetS are mainly due to the antioxidant and anti-inflammatory properties of the most abundant phytochemical components of such foods as polyphenols like resveratrol and oleuropein, allyl sulfides, ellagic acid, mono- and poly-unsaturated fatty acids (MUFA and PUFA), tocopherols and flavonoids like quercetin, which have shown positive results in the prevention of cardiovascular diseases (CVDs), with related risk factors, like hypertension, hypercholesterolemia and obesity. In this review, we highlighted the multi-target activities of the bioactive components contained in some foods typical of the Mediterranean area like olive oil, onion, liquorice, rosemary, oregano, hazelnut, pistachio, "Melannurca" apple, red wine, hot pepper, Citrus sp. fruits, saffron and garlic, with particular focus on their impact on health outcomes in relation to MetS main key factors, such as insulin resistance (IR) and type 2 diabetes mellitus (T2DM), endothelial dysfunctions, inflammatory response, oxidative stress and dyslipidaemic and hypercholesterolemic effects.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Bagetta D,Maruca A,Lupia A,Mesiti F,Catalano R,Romeo I,Moraca F,Ambrosio FA,Costa G,Artese A,Ortuso F,Alcaro S,Rocca R

doi

10.1016/j.ejmech.2019.111903

subject

Has Abstract

pub_date

2020-01-15 00:00:00

pages

111903

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(19)31055-4

journal_volume

186

pub_type

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