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Norharmane as a potential chemical entity for development of anticancer drugs.

Abstract：

:Cancer is a leading cause of death generally, and to overcome this problem the introduction of a new drug developing is a continuous endeavour. An alkaloid, norharmane and its derivatives, which have anticancer activities, widely distributed in several living and synthetic chemical sources. Herewith, the suggested mechanisms of organic reactions and synthetic approaches of norharmane available so far were considered. Active sites of norharmane nucleus positions, C-1, C-3, and N-9, were used for developing new molecules and based on structure activity relationship (SAR), those have been seen with anticancer activities. This review summarizes on chemistry of synthetic strategies of norharmane derivatives, which may provide a framework to design a novel anticancer drug, in future.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Sahoo CR,Paidesetty SK,Padhy RN

doi

10.1016/j.ejmech.2018.11.024

subject

Has Abstract

pub_date

2019-01-15 00:00:00

pages

752-764

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(18)30982-6

journal_volume

162

pub_type

杂志文章,评审

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