Abstract：
:Tuberculosis (TB) is a lift-threatening chronic deadliest infectious disease caused predominantly by Mycobacterium tuberculosis (MTB) which affects primarily the lungs (pulmonary TB) apart from other vital organs. The emergence of drug-resistant TB (DR-TB), multidrug-resistant TB (MDR-TB), extensively drug-resistant TB (XDR-TB) and the recently cases of totally drug resistant (TDR) towards currently accessible standard drugs was increased up to alarming level in the recent decades. In pursuit of searching new anti-TB agents, numerous of derivatives have been synthesized and screened for their anti-TB activity. Coumarins are one of the most important classes of natural products that exhibited various biological activities, and their derivatives regarded as a new class of effective anti-TB candidates owing to their potential anti-TB activity. Thus, coumarin skeleton has attracted great interest in the development of new anti-TB agents. This review outlines the advances in the application of coumarin-containing derivatives as anti-TB agents and the critical aspects of design and structure-activity relationship of these derivatives.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Hu YQ,Xu Z,Zhang S,Wu X,Ding JW,Lv ZS,Feng LSdoi
10.1016/j.ejmech.2017.05.004subject
Has Abstractpub_date
2017-08-18 00:00:00pages
122-130eissn
0223-5234issn
1768-3254pii
S0223-5234(17)30365-3journal_volume
136pub_type
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