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Synthesis and biological evaluation of a novel series of 1,5-benzothiazepine derivatives as potential antimicrobial agents.

Abstract：

:Two series of novel 1,5-benzothiazepine derivatives (23 compounds) were efficiently synthesized and evaluated for antibacterial and antifungal activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compound 2e exhibited the greatest antimicrobial activity. Preliminary study of the structure-activity relationship revealed that substituents in phenyl rings had a great effect on the antimicrobial activity of these compounds.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Wang L,Zhang P,Zhang X,Zhang Y,Li Y,Wang Y

doi

10.1016/j.ejmech.2008.12.021

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

2815-21

issue

7

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00622-3

journal_volume

44

pub_type

杂志文章

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