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Synthesis of some new 5-(2-substituted-1,3-thiazol-5-yl)-2-hydroxy benzamides and their 2-alkoxy derivatives as possible antifungal agents.

Abstract：

:The 2-hydroxy-5-(1,3-thiazol-5-yl) benzamide (4a), 5-(2-amino-1, 3-thiazol-5-yl)-2-hydroxy benzamide (4b), 2-hydroxy-5-(2-alkyl-1,3-Thiazol-5-yl) benzamide (4c and 4d), 5-(2-[(N-substituted aryl)amino]-1,3-thiazol-5-yl)2-hydroxy benzamides (6a-j) were prepared by reacting 5-(bromoacetyl) salicylamide (2) with thiourea, thioformamide, thioalkylamide (3c-d) and substituted thioureas (5a-j) in absolute ethanol. These compounds were converted to 5-(2-substituted-1,3-thiazol-5-yl)-2-alkoxybenzamides and 5-(2-N-(substituted aryl)-1,3-thiazol-5-yl)-2-alkoxy benzamides (8a-g) by reacting with n-alkylbromides (7a-b) in presence of a base. The newly synthesized compounds were characterized by IR, (1)H-NMR and mass spectral data. Compounds were also screened for their antifungal activity.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Narayana B,Vijaya Raj KK,Ashalatha BV,Kumari NS,Sarojini BK

doi

10.1016/j.ejmech.2004.06.003

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

867-72

issue

10

eissn

0223-5234

issn

1768-3254

pii

S0223523404001217

journal_volume

39

pub_type

杂志文章

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