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Synthesis and biological activities of dithiocarbamates containing 2(5H)-furanone-piperazine.

Abstract：

:A series of new dithiocarbamates containing a 2(5H)-furanone-piperazine group was synthesized. These compounds show good in vitro cytoxic activity. Among them, compound 6c exhibits the best inhibitory activity against HeLa cell lines with an IC50 of 0.06 ± 0.01 μM for 72 h, and it has good inhibitory activity against SMMC-7721 cell lines with an IC50 of 0.006 ± 0.04 μM for 72 h, but the toxicity was lower against LO2 cell lines with an IC50 of 45.76 ± 0.01 μM. The result showed that compound 6c is far more cytoxic towards cancer cell lines than towards benign cell lines compared with cytosine arabinoside (ARA) in vitro.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Wei MX,Zhang J,Ma FL,Li M,Yu JY,Luo W,Li XQ

doi

10.1016/j.ejmech.2018.05.056

subject

Has Abstract

pub_date

2018-07-15 00:00:00

pages

165-170

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(18)30481-1

journal_volume

155

pub_type

杂志文章

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