Abstract:
:Various substituted 3-aryl-1-isoquinolinamines were designed and synthesized based on the previously constructed CoMFA model. Most of the synthesized compounds showed excellent potency in eight different human tumor cell lines as expected. In order to find the exact cytotoxic mechanism of these 3-aryl-1-isoquinolinamines, we analyzed the cell cycle dynamics by flow cytometry and found that 3-aryl-1-isoquinolinamine 6k-treated HeLa cells were arrested in G2/M phase, which is related to apoptosis.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Yang SH,Van HT,Le TN,Khadka DB,Cho SH,Lee KT,Lee ES,Lee YB,Ahn CH,Cho WJdoi
10.1016/j.ejmech.2010.08.042subject
Has Abstractpub_date
2010-11-01 00:00:00pages
5493-7issue
11eissn
0223-5234issn
1768-3254pii
S0223-5234(10)00620-3journal_volume
45pub_type
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