Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA.

Abstract:

:Various substituted 3-aryl-1-isoquinolinamines were designed and synthesized based on the previously constructed CoMFA model. Most of the synthesized compounds showed excellent potency in eight different human tumor cell lines as expected. In order to find the exact cytotoxic mechanism of these 3-aryl-1-isoquinolinamines, we analyzed the cell cycle dynamics by flow cytometry and found that 3-aryl-1-isoquinolinamine 6k-treated HeLa cells were arrested in G2/M phase, which is related to apoptosis.

journal_name

Eur J Med Chem

authors

Yang SH,Van HT,Le TN,Khadka DB,Cho SH,Lee KT,Lee ES,Lee YB,Ahn CH,Cho WJ

doi

10.1016/j.ejmech.2010.08.042

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

5493-7

issue

11

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00620-3

journal_volume

45

pub_type

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