Abstract:
:All of the mono isopentenyloxy, -geranyloxy and -farnesyloxy derivatives of coumarin were synthesized and their inhibitory potency against soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (HLO-1) were determined. Amongst the synthetic analogs, 5-farnesyloxycoumarin showed the most potent inhibitory activity against SLO (IC(50) = 0.8 μM) while 6-farnesyloxycoumarin was the strongest HLO-1 inhibitor (IC(50) = 1.3 μM). The IC(50) variations of the farnesyl derivatives for HLO-1 (1.3 to ∼75 μM) were much higher than that observed for SLO (0.8-5.8 μM). SAR studies showed that hydrogen bonding, CH/π, anion-π and S-OC interactions with Fe(III)-OH, Leu408, Glu357 and Met419 were the distinct intermolecular interactions which can lead to important role of the coumarin substitution site in HLO-1 inhibitory potency, respectively.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Iranshahi M,Jabbari A,Orafaie A,Mehri R,Zeraatkar S,Ahmadi T,Alimardani M,Sadeghian Hdoi
10.1016/j.ejmech.2012.09.006subject
Has Abstractpub_date
2012-11-01 00:00:00pages
134-42eissn
0223-5234issn
1768-3254pii
S0223-5234(12)00545-4journal_volume
57pub_type
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