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Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation.

Abstract：

:Deoxypodophyllotoxin is stereoselectively converted into epipodophyllotoxin by recombinant human cytochrome P450 3A4 (CYP3A4). Further kinetic analysis revealed that the Michaelis-Menten K(m) and V(max) for hydroxylation of deoxypodophyllotoxin by CYP3A4 at C7 position were 1.93 microM and 1.48 nmol/min/nmol, respectively. Deoxypodophyllotoxin was subjected to automated docking analysis in order to get better knowledge of the interaction between the CYP3A4 enzyme and the substrate, using the PatchDock algorithm with distance constraints. Automated docking showed that the beta-hydrogen atom at C7 position is in the most appropriate binding orientation at the site of oxidation. The docking results are consistent with the experimental data for the bioconversion of deoxypodophyllotoxin into epipodophyllotoxin by CYP3A4. In addition, the effects of five lignans, deoxypodophyllotoxin, epipodophyllotoxin, podophyllotoxin, demethylenedeoxypodophyllotoxin, and demethylenepodophyllotoxin, on CYP3A4 were compared in order to investigate the influence of the methylenedioxy group on the biotransformation process, to give insight into the mode of metabolization and to explain inhibitory activity of lignans.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Julsing MK,Vasilev NP,Schneidman-Duhovny D,Muntendam R,Woerdenbag HJ,Quax WJ,Wolfson HJ,Ionkova I,Kayser O

doi

10.1016/j.ejmech.2007.09.005

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

1171-9

issue

6

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(07)00342-X

journal_volume

43

pub_type

杂志文章

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