Design, synthesis and docking studies of quinoline-oxazolidinone hybrid molecules and their antitubercular properties.

Abstract:

:New series of quinoline-oxazolidinone hybrid molecules were synthesized based on the preliminary docking studies. All the newly synthesized compounds were characterized by spectral analyses. The newly synthesized compounds were screened for their antimycobacterial properties based on the promising preliminary antibacterial screening results. Amongst tested compounds, compounds 8a, 8j and 13a were active at 0.65 μg/mL against Mycobacterium tuberculosis H(37)Rv strain. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands 8a, 8j and 13a. These compounds exhibited well established bonds with one or more amino acids in the receptor active pocket. From the docking studies, compound 8j was considered to be the best inhibitor.

journal_name

Eur J Med Chem

authors

Thomas KD,Adhikari AV,Chowdhury IH,Sandeep T,Mahmood R,Bhattacharya B,Sumesh E

doi

10.1016/j.ejmech.2011.07.049

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

4834-45

issue

10

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(11)00562-9

journal_volume

46

pub_type

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