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Synthesis and antimicrobial evaluation of novel analogues of dehydroabietic acid prepared by CH-Activation.

Abstract：

:Dehydroabietic acid (DHAA) plays an important role in drug discovery. Its modification at chemically reactive positions has been exploited to a large extent over the last decades, generating a wide range of analogues. In contrast, introduction of substituents at chemically inert positions remains a sizeable challenge. Hereby we wish to report the synthesis of a first series of C-19-arylated DHAA-analogues by application of a simple CH activation protocol, as well as their antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA).

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Berger M,Roller A,Maulide N

doi

10.1016/j.ejmech.2016.12.012

subject

Has Abstract

pub_date

2017-01-27 00:00:00

pages

937-943

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(16)31018-2

journal_volume

126

pub_type

杂志文章

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