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Epoxide-containing side chains enhance antiproliferative activity of paullones.

Abstract：

:The introduction of side chains bearing epoxide motifs into the molecular scaffold of kenpaullone and 9-trifluoromethylpaullone led to improved antiproliferative activity of the novel derivatives for human tumor cell lines. The syntheses were accomplished applying Stille coupling for the introduction of unsaturated side chains into the 2-position of the paullones and subsequently employing a hydrogen peroxide/nitrile mixture for the epoxidation of C,C-double bonds.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Xie X,Lemcke T,Gussio R,Zaharevitz DW,Leost M,Meijer L,Kunick C

doi

10.1016/j.ejmech.2005.02.004

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

655-61

issue

7

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(05)00051-6

journal_volume

40

pub_type

杂志文章

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