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Synthesis and antimicrobial activities of novel 1,5-diaryl pyrazoles.

Abstract：

:Novel 1,5-diaryl pyrazole derivatives viz. 5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamides (2a-e, 3, 3a-f), 2-(5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-yl)thiazoles (6a-c,7, 8, 9a-c, 10, 11) were synthesized by varying the active part (amide group) of pyrazole, characterized using IR, (1)H NMR, mass spectral data and screened for their antibacterial activity against Escherichia coli (ATTC-25922), Staphylococcus aureus (ATTC-25923), Pseudomonas aeruginosa (ATTC-27853), Klebsiella pneumonia. Similarly all these compounds were screened for their antifungal activity against Aspergillus flavus (NCIM No. 524), Aspergillus fumigates (NCIM No. 902), Penicillium marneffei and Trichophyton mentagrophytes. Interestingly all the synthesized compounds exhibited good antibacterial (except 2a-c, 8, 9a) and antifungal activity (except 2a-c, 6a, 8, 9a).

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Ragavan RV,Vijayakumar V,Kumari NS

doi

10.1016/j.ejmech.2009.12.042

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

1173-80

issue

3

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(09)00686-2

journal_volume

45

pub_type

杂志文章

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