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Heparin-polynitroxides: synthesis and preliminary evaluation as cardiovascular EPR/MR imaging probes and extracellular space-targeted antioxidants.

Abstract：

:We report here the synthesis of heparin-polynitroxide derivatives (HPNs) in which nitroxide moieties are linked either to uronic acid or glycosamine residues of the heparin macromolecule. HPNs have low anticoagulant activity, possess superoxide scavenging properties, bind to the vascular endothelium/extra-cellular matrix and can be detected by EPR and MRI techniques. As the vascular wall-targeted redox-active paramagnetic compounds, HPNs may have both diagnostic (molecular MRI) and therapeutic (ecSOD mimics) applications.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Kleschyov AL,Sen' V,Golubev V,Münnemann K,Hinderberger D,Lackner KJ,Weber S,Terekhov M,Schreiber LM,Münzel T

doi

10.1016/j.ejmech.2012.09.028

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

265-71

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(12)00567-3

journal_volume

58

pub_type

杂志文章

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