Abstract:
:Discovered in late 1960, azoles are heterocyclic compounds class which constitute the largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical component that confers activity to azoles. Triazoles are obtained by a slight modification of this ring and similar or improved activities as well as less adverse effects are reported for triazole derivatives. Consequently, it is not surprising that benzimidazole/benzotriazole derivatives have been found to be biologically active. Since benzimidazole has been widely investigated, this review is focused on defining the place of benzotriazole derivatives in biomedical research, highlighting their versatile biological properties, the mode of action and Structure Activity Relationship (SAR) studies for a variety of antimicrobial, antiparasitic, and even antitumor, choleretic, cholesterol-lowering agents.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Briguglio I,Piras S,Corona P,Gavini E,Nieddu M,Boatto G,Carta Adoi
10.1016/j.ejmech.2014.09.089subject
Has Abstractpub_date
2015-06-05 00:00:00pages
612-48eissn
0223-5234issn
1768-3254pii
S0223-5234(14)00917-9journal_volume
97pub_type
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