Mathematical modeling of fluid dynamics in pulsatile cardiopulmonary bypass.

abstract：:Hypertension is an important primary etiology of end-stage renal disease as well as a major factor responsible for progression of renal disease due to other causes. Multiple genetic and environmental factors are responsible for the variable prevalence of hypertension in various parts of the world. Although the frequen...

journal_title：Artificial organs

authors： El-Khashab O

更新日期：2002-09-01 00:00:00

abstract：:Cardiopulmonary bypass (CPB) requirement in infants presents a unique challenge because of the large prime volume-to-blood volume ratio. Packed red blood cells (PRBCs) tend to deteriorate with long-term storage owing to their unphysiological composition and osmolality. Given that blood priming is inevitable in neonate...

journal_title：Artificial organs

authors： Gholampour Dehaki M,Niknam S,Bakhshandeh H,Azarfarin R

更新日期：2020-03-01 00:00:00

abstract：:Hemodynamic control of left ventricular assist devices (LVADs) is generally a complicated problem due to diverse operating environments and the variability of the patients: both the changes in the circulatory and metabolic parameters as well as disturbances that require adjustment to the operating point. This challeng...

journal_title：Artificial organs

authors： Choi S,Boston JR,Antaki JF

更新日期：2007-02-01 00:00:00

abstract：:This article presents computational studies on the effects of inlet guide vanes (IGVs) on the flow pattern and shear stress in a centrifugal blood pump. The effect of IGVs is to introduce a pre-swirl to fluid particles entering the impeller with the intention that the fluid particles will travel along the blade profil...

journal_title：Artificial organs

authors： Chan WK,Wong YW,Yu SC,Chua LP

更新日期：2002-06-01 00:00:00

abstract：:The generation of anaphylatoxins, particularly C5a, is important in extracorporeal circulation therapies such as granulocyte/monocyte apheresis, which activates the complement system and elevates C5a levels. However, no side effects of granulocyte/monocyte apheresis using cellulose acetate beads have been reported. To...

journal_title：Artificial organs

authors： Takeda Y,Ohba M,Ueno M,Saniabadi AR,Wakabayashi I

更新日期：2010-12-01 00:00:00

abstract：:Modeling different treatment options before a procedure is performed is a promising approach for surgical decision making and patient care in heart valve disease. This study investigated the hemodynamic impact of different prostheses through patient-specific MRI-based CFD simulations. Ten time-resolved MRI data sets w...

journal_title：Artificial organs

authors： Hellmeier F,Nordmeyer S,Yevtushenko P,Bruening J,Berger F,Kuehne T,Goubergrits L,Kelm M

更新日期：2018-01-01 00:00:00

abstract：:Extracorporeal membrane oxygenation (ECMO) is used for severe acute respiratory distress syndrome. However, available ECMO systems are large and not well designed for fast delivery, emergency implantation, and interhospital transfer. Therefore, a new miniaturized oxygenator with integrated rotary blood pump (ILIAS) wa...

journal_title：Artificial organs

authors： Pilarczyk K,Heckmann J,Lyskawa K,Strauß A,Haake N,Wiese I,Jakob H,Kamler M,Pizanis N

更新日期：2016-07-01 00:00:00

abstract：:This study demonstrates in a novel way how volume and shape are restored to denervated degenerated muscles due to a special pattern of electrical stimulation. To this purpose, Spiral Computer Tomography (CT) and special image processing tools were used to develop a method to isolate the rectus femoris from other muscl...

journal_title：Artificial organs

authors： Gargiulo P,Vatnsdal B,Ingvarsson P,Knútsdóttir S,Gudmundsdóttir V,Yngvason S,Helgason T

更新日期：2008-08-01 00:00:00

abstract：:Cardiopulmonary bypass (CPB) is required in some lung transplantation (LTx) operations. However, it increases risks of bleeding and early graft dysfunction. We report our experiences of replacing CPB with heparin-bound extracorporeal membrane oxygenation (ECMO) in LTx operations. If extracorporeal circulation was anti...

journal_title：Artificial organs

authors： Ko WJ,Chen YS,Lee YC

更新日期：2001-08-01 00:00:00

abstract：:Neurologic complications during on-pump cardiovascular surgery are often induced by mobilization of atherosclerotic plaques, which is directly related to enhanced wall shear stress. In the present study, we numerically evaluated the impact of dispersive aortic cannulas on aortic blood flow characteristics, with specia...

journal_title：Artificial organs

authors： Assmann A,Gül F,Benim AC,Joos F,Akhyari P,Lichtenberg A

更新日期：2015-03-01 00:00:00

abstract：:The clearance characteristics of two sizes of hemodialyzers (0.9 m2 and 1.5 m2) from the same range of products have been studied over the dialysate flow range of 500-3,000 ml/min to establish the device's overall mass transfer resistance characteristics. The results obtained demonstrate a difference in the overall ma...

journal_title：Artificial organs

authors： Allen R,Frost TH,Hoenich NA

更新日期：1995-11-01 00:00:00

abstract：:Pyridoxalated-hemoglobin-polyoxyethylene conjugate (PHP), which is made from out-dated human red blood cells by two major chemical modifications, namely pyridoxalation and conjugation with polyoxyethylene (POE), is currently under development as a physiological oxygen carrier. This study assessed the effects of PHP-88...

journal_title：Artificial organs

authors： Takahashi T,Iwasaki K,Malchesky PS,Harasaki H,Matsushita M,Nosé Y,Rolin H 3rd,Hall PM

更新日期：1993-03-01 00:00:00

abstract：:For the development of a totally implantable ventricular assist system (VAS), we have been developing the vibrating flow pump (VFP), which can generate oscillated blood flow with a relative high frequency (10-50 Hz) for a totally implantable system. In this study, the effects of left ventricular assistance with this u...

journal_title：Artificial organs

authors： Nitta S,Yambe T,Kobayashi S,Hashimoto H,Yoshizawa M,Mastuki H,Tabayashi K,Takeda H

更新日期：1999-01-01 00:00:00

abstract：:The blood flow through the hemofilter device is the key point for ultrafiltrate production during continuous arteriovenous hemofiltration. It mainly depends on arteriovenous pressure gradient and vascular access, which is the major problem for arteriovenous hemofiltration in infants and small children. In infants, we ...

journal_title：Artificial organs

authors： Zobel G,Trop M,Beitzke A,Ring E

更新日期：1988-02-01 00:00:00

abstract：:Nonpulsatile blood pumps are mainly used in extracorporeal life support systems. Although pulsating blood flow is known to be physiological, a pulsatile pump is not commonly applied in a circuit with a membrane oxygenator because of damage to the blood cells. The hypothesis that the placement of a pressure-relieving c...

journal_title：Artificial organs

authors： Kim TS,Sun K,Lee KB,Lee HW,Baek KJ,Park SY,Son HS,Kim KT,Kim HM

更新日期：2004-12-01 00:00:00

abstract：:Sera from 138 patients who had experienced hypersensitivity-type reactions while on hemodialysis (reactors) were examined retrospectively by the radioallergosorbent test (RAST) for specific IgE antibody to ethylene oxide (ETO). Seventy-eight hemodialysis patients without a history of reaction were also evaluated as co...

journal_title：Artificial organs

authors： Pearson F,Bruszer G,Lee W,Sagona M,Sargent H,Woods E,Dolovich J,Caruana R

更新日期：1987-04-01 00:00:00

abstract：:Technological innovations in pediatric extracorporeal life support circuits can reduce system-related complications and may improve patients' outcome. The Deltastream DP3 (Medos Medizintechnik AG, Stolberg, Germany) is a novel rotational pump with a diagonally streamed impeller that can be used over a broad range of f...

journal_title：Artificial organs

authors： Stiller B,Houmes RJ,Rüffer A,Kumpf M,Müller A,Kipfmüller F,Köditz H,Herber Jonat S,Schmoor C,Benk C,Tibboel D,Fleck T

更新日期：2018-04-01 00:00:00

abstract：:Left ventricular assist devices (LVADs) are increasingly being used as life-saving therapy in patients with end-stage heart failure. The changes in spirometry following LVAD implantation and subsequent unloading of the left ventricle and pulmonary circulation are unknown. In this study, we explored long-term changes i...

journal_title：Artificial organs

authors： Mohamedali B,Bhat G,Yost G,Tatooles A

更新日期：2015-12-01 00:00:00

abstract：:Bubble blood oxygenators equipped with baffles of various types in the oxygenating column were studied. The rate of hemolysis, the volumetric coefficient for oxygen absorption into blood, and the fractional gas holdup were found to be affected mainly by the superficial gas velocity. When compared with the conventional...

journal_title：Artificial organs

authors： Ohshima N,Yoshido F

更新日期：1979-05-01 00:00:00

abstract：:A small and light direct-drive centrifugal pump has been developed for cardiopulmonary bypass. In the development process, blood compatibility studies including a hemolysis study, an in vitro fluid dynamic performance study, and in vivo durability and feasibility studies were performed. The centrifugal pump with a 50 ...

journal_title：Artificial organs

authors： Jikuya T,Sasaki T,Aizawa T,Shiono M,Glueck JA,Smith CP,Feldman L,Sakuma I,Sekela ME,Noda T

更新日期：1992-12-01 00:00:00

abstract：:A rise in intracellular calcium concentration in erythrocytes has multiple effects on these cells. The purpose of this study was to determine the changes of calcium content in red blood cells (RBCs) and of echinocyte percentages in uremic patients during hemodialysis sessions. In 30 uremic patients under hemodialysis,...

journal_title：Artificial organs

authors： Agroyannis B,Kopelias I,Fourtounas C,Paraskevopoulos A,Tzanatos H,Dalamangas A,Mallas E

更新日期：2001-06-01 00:00:00

abstract：:Although current continuous-flow total artificial hearts (CFTAHs) are much smaller than previous models, venous kinking may still occur after device implantation, especially in smaller animals. By inserting a self-expanding stent at the site of venous narrowing in a sheep model implanted with a CFTAH, we were able to ...

journal_title：Artificial organs

authors： Tuzun E,Parnis S,Rios J,Winkler JA,Cohn WE

更新日期：2011-07-01 00:00:00

abstract：:Most bioartificial liver support systems are based on hollow fiber capillaries within modified dialysis cartridges or more sophisticated bioreactor constructions. Due to their design microscopic follow-up of reorganization and growth of tissue between the hollow fibers is not possible. The SlideReactor is a simple hol...

journal_title：Artificial organs

authors： Sauer IM,Schwartlander R,Schmid J,Efimova E,Vondran FW,Kehr D,Pless G,Spinelli A,Brandenburg B,Hildt E,Neuhaus P

更新日期：2005-03-01 00:00:00

abstract：:In patients undergoing exchange-transfusion with hemoglobin (Hb)-based oxygen (O₂) carriers (HBOC), native Hb coexists with newly transfused Hb. The two Hb types share the same arterial and venous PO₂, but their affinities for O₂ vary. A simple spreadsheet model is described aiming at evaluating the contribution of ea...

journal_title：Artificial organs

authors： Samaja M,Terraneo L

更新日期：2012-02-01 00:00:00

abstract：:Different from the existing tissue engineering strategies, rapid prototyping (RP) techniques aim to automatically produce complex organs directly from computer-aided design freeform models with high resolution and sophistication. Analogous to building a nuclear power plant, cell biology (especially, renewable stem cel...

journal_title：Artificial organs

authors： Wang X

更新日期：2012-11-01 00:00:00

abstract：:A beta2-microglobulin (beta2M) selective adsorbent (Lixelle) for direct hemoperfusion has been used for the treatment of hemodialysis patients with the long-term complication of dialysis related amyloidosis (DRA), but there is no significant correlation between the serum level of beta2M and the occurrence of DRA. Infl...

journal_title：Artificial organs

authors： Tsuchida K,Takemoto Y,Nakamura T,Fu O,Okada C,Yamagami S,Kishimoto T

更新日期：1998-12-01 00:00:00

abstract：:Mechanical circulatory support (MCS) devices continue to be hampered by thrombotic adverse events (AEs), a consequence of device-imparted supraphysiologic shear stresses, leading to shear-mediated platelet activation (SMPA). In advancing MCS devices from design to clinical use, in vitro circulatory loops containing th...

journal_title：Artificial organs

authors： Li M,Walk R,Roka-Moiia Y,Sheriff J,Bluestein D,Barth EJ,Slepian MJ

更新日期：2020-06-01 00:00:00

abstract：:Excessive left ventricular (LV) volume unloading can affect right ventricular (RV) function by causing a leftward shift of the interventricular septum in patients with mitral regurgitation (MR) receiving left ventricular assist device (LVAD) support. Optimal settings for the LVAD should be chosen to appropriately cont...

journal_title：Artificial organs

authors： Naito N,Nishimura T,Takewa Y,Kishimoto S,Date K,Umeki A,Ando M,Ono M,Tatsumi E

更新日期：2016-11-01 00:00:00

abstract：:We treated 12 patients with rheumatoid arthritis by filtration leukocytapheresis (FLCP) and evaluated its effect on leukocyte enzyme activities. We calculated the number of leukocytes removed and assessed the clinical response. We also evaluated the cellular enzyme activities of elastase and dipeptidylpeptidase IV (DP...

journal_title：Artificial organs

authors： Yamasaki S,Ueki Y,Nakamura H,Yano M,Matsumoto K,Miyake S,Tominaga T,Tominaga M,Eguchi K

更新日期：2002-04-01 00:00:00

abstract：:Thousands of ventricular assist devices (VADs) currently provide circulatory support to patients worldwide, and dozens of heart pump designs for adults and pediatric patients are under various stages of development in preparation for translation to clinical use. The successful bench-to-bedside development of a VAD inv...

journal_title：Artificial organs

authors： Throckmorton AL,Patel-Raman SM,Fox CS,Bass EJ

更新日期：2016-06-01 00:00:00