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A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im.

Abstract：

:Human cleavage factor I(m) (CFI(m)) is a heterodimeric RNA binding protein complex that functions at an early step in the assembly of the pre-mRNA 3' processing complex. In this report we show that CFI(m) can stimulate both cleavage and poly(A) addition, and can act to suppress poly(A) site cleavage in a sequence-dependent manner. Elevated levels of CFI(m) suppressed cleavage at the primary poly(A) site of the pre-mRNA encoding the 68 kDa subunit of CFI(m). CFI(m)-mediated suppression of poly(A) site cleavage was dependent upon the presence of three copies of an RNA element initially identified by CFI(m)-SELEX. These data provide evidence for a mechanism for the regulation of poly(A) site selection by a basal pre-mRNA 3' processing factor.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Brown KM,Gilmartin GM

doi

10.1016/s1097-2765(03)00453-2

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

1467-76

issue

6

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(03)00453-2

journal_volume

12

pub_type

杂志文章

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