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The tangled circuitry of metabolism and apoptosis.

Abstract：

:For single-cell organisms, nutrient uptake and metabolism are central to the fundamental decision of whether to grow or divide. In metazoans, cell fate decisions are more complex: organismal homeostasis must be strictly maintained by balancing cell proliferation and death. Despite this increased complexity, cell fate within multicellular organisms is also influenced by metabolism; recent studies, triggered in part by an interest in tumor metabolism, are beginning to illuminate the mechanisms through which proliferation, death, and metabolism are intertwined. In particular, work on Bcl-2 family proteins suggests that the signaling pathways governing metabolism and apoptosis are inextricably linked. Here we review the crosstalk between these pathways, emphasizing recent work that illustrates the emerging dual nature of several core apoptotic proteins in regulating both metabolism and cell death.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Andersen JL,Kornbluth S

doi

10.1016/j.molcel.2012.12.026

subject

Has Abstract

pub_date

2013-02-07 00:00:00

pages

399-410

issue

3

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(13)00051-8

journal_volume

49

pub_type

杂志文章,评审

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