Abstract:
:Human glioblastoma is a highly lethal tumor known for its capability of interfering with effective antitumor immune responses. Costimulatory signals are of critical relevance in both the inductive and effector phases of immune responses. Inducible costimulator-ligand (ICOSL), a member of the B7 family of costimulatory molecules related to CD80/CD86, regulates CD4 as well as CD8 T-cell responses via interaction with its receptor, ICOS, on activated T cells. We report the expression of ICOSL by glioma cells in vitro and in vivo. In contrast to CD80 (B7.1) and CD86 (B7.2), ICOSL protein and mRNA was expressed in 7 of 12 glioma cell lines. ICOSL expression is upregulated by the inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), whereas interferon-gamma (IFN-gamma) has no such effect. Further, immunohistochemical analysis of human brain tumors demonstrates the expression of ICOSL in three of four tissue samples. ICOSL expression is functional in that a neutralizing ICOSL antibody (HIL-131) reduces Th1 and Th2 cytokine levels in cocultures of peripheral blood lymphocytes or T-cell subsets (CD4 and CD8) with glioma cells. However, ICOSL gene transfer into glioma cells does not alter their immunogenicity under primary or secondary alloreactive coculture assays.
journal_name
Gliajournal_title
Gliaauthors
Schreiner B,Wischhusen J,Mitsdoerffer M,Schneider D,Bornemann A,Melms A,Tolosa E,Weller M,Wiendl Hdoi
10.1002/glia.10291subject
Has Abstractpub_date
2003-12-01 00:00:00pages
296-301issue
3eissn
0894-1491issn
1098-1136journal_volume
44pub_type
杂志文章相关文献
GLIA文献大全abstract::Injection of Fluoro-Gold (FG) into the whisker pad of rats yields a stable retrograde labeling of facial motoneurons. After removal of 10 mm from the facial nerve the microglia phagocytose the FG-prelabeled dead neurons and assume the label. A subsequent brightfield immunostaining of the sections with HRP-DAB as end-p...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1136(199602)16:2<129::AID-GLIA5
更新日期:1996-02-01 00:00:00
abstract::Astrocytes are thought to play a variety of key roles in the adult brain, such as their participation in synaptic transmission, in wound healing upon brain injury, and adult neurogenesis. However, to elucidate these functions in vivo has been difficult because of the lack of astrocyte-specific gene targeting. Here we ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20350
更新日期:2006-07-01 00:00:00
abstract::Heterosynaptic long-term depression (hLTD) at untetanized synapses accompanying the induction of long-term potentiation (LTP) spatially sharpens the activity-induced synaptic potentiation; however, the underlying mechanism remains unclear. We found that hLTD in the hippocampal CA1 region is caused by stimulation-induc...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22425
更新日期:2013-02-01 00:00:00
abstract::Radial glial cells play an essential role through their function as guides for neuronal migration during development. Disruption of metabotropic glutamate receptor 5 (mGluR5) function retards the growth of radial glial processes in vitro. Neuregulins (NRG) are activated by proteolytic cleavage and regulate (radial) gl...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23230
更新日期:2018-01-01 00:00:00
abstract::Schwann cells (SCs) and olfactory ensheathing glia (OEG) have shown promise for spinal cord injury repair. We sought their in vivo identification following transplantation into the contused adult rat spinal cord at 1 week post-injury by: (i) DNA in situ hybridization (ISH) with a Y-chromosome specific probe to identif...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20490
更新日期:2007-07-01 00:00:00
abstract::Long-term, persistent central nervous system inflammation is commonly seen following brain infection. Using a murine model of viral encephalitis (murine cytomegalovirus, MCMV) we have previously shown that post-encephalitic brains are maintained in an inflammatory state consisting of glial cell reactivity, retention o...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22868
更新日期:2015-11-01 00:00:00
abstract::Glial cells play a crucial role in the organization and function of the nervous system. Cell-cell adhesion receptors of the cadherin family have been shown to participate in distinct morphogenetic processes throughout the development of the CNS, but little is known about glial expression of cadherins. Applying immunof...
journal_title:Glia
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::Insulin-like growth factor II (IGFII) acts as a potent mitogen for several tumor types and has been reported to positively influence astrocytoma cell growth and motility. In the central nervous system, IGFII bioavailability is mainly modulated by insulin-like growth factor binding protein 2 (IGFBP2), which sequestrate...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20719
更新日期:2008-11-15 00:00:00
abstract::Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of gray matter. This phenomenon is believed to underlie the migraine aura and similar waves of depolarization may exacerbate injury in a number of neurological disease states. CSD is characterized by massive ion dyshomeostasis, cell swe...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23604
更新日期:2019-06-01 00:00:00
abstract::Several lines of evidence indicate that the elaborated calcium signals and the occurrence of calcium waves in astrocytes provide these cells with a specific form of excitability. The identification of the cellular and molecular steps involved in the triggering and transmission of Ca(2+) waves between astrocytes result...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.20374
更新日期:2006-11-15 00:00:00
abstract::Gap junctions are regarded as the primary pathway underlying propagation of Ca2+ waves between astrocytes, although signaling through extracellular space may also contribute. Results obtained from astrocytes cultured from sibling Cx43 knockout (KO) and wild-type (WT) mice in six litters showed that Ca2+ waves propagat...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199809)24:1<65::aid-glia7>
更新日期:1998-09-01 00:00:00
abstract::Glial cells execute essential functions in central nervous system (CNS) development and are also believed to play important roles during gliosis in response to trauma or disease. These developmental and pathological states have also been associated with elevated expression of opioid genes. Because levels of the cytoki...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440060308
更新日期:1992-01-01 00:00:00
abstract::The extrasynaptic region of the squid giant nerve fiber exhibits neuron-Schwann cell interactions that appear to involve glutamate as a mediator. In an earlier work, it was demonstrated that the periaxonal sheaths of such nerves (where the Schwann cells are located) possess the capacity to transport glutamate. However...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199808)23:4<298::aid-glia2
更新日期:1998-08-01 00:00:00
abstract::There is a critical relationship between oligodendrocyte development, myelin production, and iron bioavailability. Iron deficiency leads to hypomyelination both in humans and animal models, and the neurological sequelae of hypomyelination are significant. Therefore, understanding molecular mechanisms of iron import in...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.21164
更新日期:2011-06-01 00:00:00
abstract::Microglia are key players of the immune response in the central nervous system (CNS) and, being the resident innate immune cells, they are responsible for the early control of infections and for the recruitment of cells of the adaptive immune system required for pathogen clearance. The innate and adaptive immune respo...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.20928
更新日期:2010-02-01 00:00:00
abstract::Glial fibrillary acidic protein (GFAP) is the principal component of the intermediary filaments in mature astrocytes of the central nervous system (CNS). The protein consists of three domains: the head, the coiled-coil, and the tail. Here, we describe the isolation of an evolutionary conserved novel GFAP isoform, GFAP...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20475
更新日期:2007-04-01 00:00:00
abstract::Increasing evidence supports an essential role for interleukin-6 (IL-6) in the development, differentiation, as well as de- and re-generation of neurons in the central nervous system (CNS). Both IL-6 and its specific receptor (IL-6R) are expressed on neurons and glial cells including astrocytes. In this study, we have...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199905)26:3<191::aid-glia1
更新日期:1999-05-01 00:00:00
abstract::Accumulating evidence indicates that astrocytes are actively involved in the physiological and pathophysiological functions of the brain. Intracellular Ca2+ signaling, especially Ca2+ release from the endoplasmic reticulum (ER), is considered to be crucial for the regulation of astrocytic functions. Mice with genetic ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23531
更新日期:2019-01-01 00:00:00
abstract::Oligodendrocyte differentiation and myelination involve dramatic changes in cell signaling pathways, gene expression patterns, cell shape, and cytoskeletal organization. In a pilot study investigating CNS angiogenesis, oligodendrocytes were intensely labeled by antisera directed against the C-terminal of Tie-2, a 140-...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20175
更新日期:2005-05-01 00:00:00
abstract::It has become evident recently only that microglia are not only responsible for immunomodulatory functions in the brain but represent vital components of the larger synaptic formation, which also includes pre and postsynaptic neurones as well as astrocytes. Microglia critically contribute to CNS homeostasis by their a...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.22372
更新日期:2013-01-01 00:00:00
abstract::C-erbB receptor/neuregulin signalling plays a significant role in Schwann cell function. In vivo, Schwann cells up-regulate expression of c-erbB receptors in the first month after injury, but receptor expression is down-regulated with time to levels that are not detectable immunohistochemically. The inability of chron...
journal_title:Glia
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::Serum is used widely for culturing neurons and glial cells, and is thought to provide essential, albeit undefined, factors such as hormones, growth factors, and trace elements that promote the growth of cells in vitro. Moreover, serum can have profound effects on cell proliferation, differentiation, and cell morpholog...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199803)22:3<237::aid-glia3
更新日期:1998-03-01 00:00:00
abstract::Astrocytes express gap junction proteins and multiple types of P2Y receptors (P2YRs) that contribute to the propagation of intercellular Ca(2+) waves (ICW). To gain access to the role played by gap junctional communication in ICW propagation generated by P2YR activation, we selectively expressed P2Y(1,2,4)R subtypes a...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20071
更新日期:2004-11-15 00:00:00
abstract::Glial fibrillary acidic protein (GFAP) is the main component of intermediate filaments in astrocytes. To assess its function in astrocyte swelling, we compared astrocyte membrane properties and swelling in spinal cord slices of 8- to 10-day-old wild-type control (GFAP(+/+)) and GFAP-knockout (GFAP(-/-)) mice. Membrane...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.1084
更新日期:2001-09-01 00:00:00
abstract::The poor regenerative ability of neurons of the central nervous system in mammals, as compared with their counterpart in fish or amphibians, is thought to stem from differences in their immediate nonneuronal environment and its response to axonal injury. We describe one aspect of the environmental response to axonal i...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440100104
更新日期:1994-01-01 00:00:00
abstract::Oligodendroglial cells undergo rapid transcriptional and dynamic morphological transformation in order to effectively myelinate neuronal axons. Olig1, a basic helix-loop-helix transcription factor, functions to promote the transcription of myelin-specific genes and promotes differentiation and (re)myelination. While t...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22364
更新日期:2012-09-01 00:00:00
abstract::Bmi1 is a polycomb group (Pc-G) protein involved in heritable gene repression, maintenance of cell identity, and proliferation. During the development of the central nervous system, Bmi1 is crucial for self-renewal of neural stem cells and for proliferation of neuronal (granule cell) progenitors of the cerebellum. Her...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.21184
更新日期:2011-07-01 00:00:00
abstract::Within the last few years, the expression of voltage-dependent, TTX-sensitive Na+ channels has been demonstrated in several types of neuroglial cells such as astrocytes and Schwann cells. Recently, we reported the occurrence of such Na+ currents in retinal Müller (glial) cells from dog and cat. This paper deals with t...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440100304
更新日期:1994-03-01 00:00:00
abstract::alpha-Synuclein, a gene whose mutations, duplication, and triplication has been linked to autosomal dominant familial Parkinson's disease (fPD), appears to play a central role in the pathogenesis of sporadic PD (sPD) as well. Enhancement of neurodegeneration induced by mutant alpha-synuclein has been attributed to dat...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20532
更新日期:2007-08-15 00:00:00
abstract::The chemokines CXCL9 and CXCL10 bind to the common receptor CXCR3 and are implicated in the pathogenesis of T-cell-mediated immunity in the central nervous system (CNS). Here we examined the temporal and spatial regulation of the Cxcl9 and Cxcl10 genes in the CNS of mice with myelin oligodendrocyte glycoprotein (MOG)-...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20587
更新日期:2007-12-01 00:00:00