Abstract:
:Chromosome paints of the rat kangaroo ( Aepyprymnus rufuscens, 2 n=32) were used to define chromosome regions in the long nosed potoroo ( Potorous tridactylus, 2 n=12 female, 13 male) karyotype and localize these regions in three-dimensionally preserved nuclei of the potoroo to test the hypothesis that marsupial chromosomes have a radial distribution. In human nuclei chromosomes are distributed in a proposed radial fashion. Gene-rich chromosomes in the human interphase nucleus are preferentially located in the central area while gene-poor chromosomes are found more at the periphery of the nucleus; this feature is conserved in primates and chicken. Chromosome ordering in nuclei of P. tridactylus is related to their size and centromere position. Its relationship with replication patterns in interphase nuclei and metaphase was studied. In addition it was observed that the nucleus was not a smooth entity but had projections occupied by specific chromosome regions.
journal_name
Chromosomajournal_title
Chromosomaauthors
Rens W,O'Brien PC,Graves JA,Ferguson-Smith MAdoi
10.1007/s00412-003-0246-4subject
Has Abstractpub_date
2003-08-01 00:00:00pages
66-76issue
2eissn
0009-5915issn
1432-0886journal_volume
112pub_type
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