Abstract：
:Homologous chromosomes initially undergo weak alignments that bring homologous sequences into register during meiosis. These alignments can be facilitated by two types of mechanisms: interstitial homology searches and telomere-telomere alignments. As prophase (and chromatin compaction) proceeds, these initial pairings or alignments need to be stabilized. In at least some organisms, such as Saccharomyces cerevisiae and S. pombe, these pairings can apparently be maintained by the creation of recombination intermediates. In contrast, synapsis during zygotene may be able to facilitate and/or maintain chromosome pairing even in the absence of exchange in several higher organisms. It thus seems possible that the synaptonemal complex plays a role both in maintaining homolog adhesion during meiotic prophase and, more speculatively, in facilitating meiotic exchange.
journal_name
Chromosomajournal_title
Chromosomaauthors
Walker MY,Hawley RSdoi
10.1007/s004120050407subject
Has Abstractpub_date
2000-01-01 00:00:00pages
3-9issue
1-2eissn
0009-5915issn
1432-0886journal_volume
109pub_type
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