A new function for heterochromatin.


:Meiotic pairing has now been shown to require heterochromatic homology and to be sensitive to repeat number in both male and female Drosophila. The increased pairing ability of repetitive sequences could be one reason that most eukaryotes allow the accumulation of tandem repeated elements. This may well be a reflection of a general role for heterochromatin, and at least a partial explanation of the ubiquity of heterochromatin through the eukaryotes.






Irick H




Has Abstract


1994-03-01 00:00:00












  • Interstrain heterochromatin polymorphisms in Drosophila melanogaster.

    abstract::Neuroblast chromosomes of 16 Drosophila melanogaster laboratory stocks (15 wild type and 1 carrying the mutant vermillion) were carefully analyzed for Q-banding patterns and morphological characteristics, in all the mitotic phases. Two forms of intraspecific heterochromatin variations, involving three types of chromos...


    pub_type: 杂志文章


    authors: Halfer C

    更新日期:1981-01-01 00:00:00

  • The organization of the evolutionarily conserved GATA/GACA repeats in the mouse genome.

    abstract::Simple repeated GATA and GACA sequences which were originally isolated from sex-specific snake satellite DNA have been found subsequently in all eukaryotes studied. The organization of these sequences within the mouse genome was investigated here by using synthetic oligonucleotide probes as a novel tool in comparison ...


    pub_type: 杂志文章


    authors: Schäfer R,Ali S,Epplen JT

    更新日期:1986-01-01 00:00:00

  • Cytogenetic and immuno-FISH analysis of the 4q subtelomeric region, which is associated with facioscapulohumeral muscular dystrophy.

    abstract::Facioscapulohumeral muscular dystrophy (FSHD) is caused by the shortening of a copy-number polymorphic array of 3.3 kb repeats (D4Z4) at one allelic 4q35.2 region. How this contraction of a subtelomeric tandem array causes FSHD is unknown but indirect evidence suggests that a short array has a cis effect on a distant ...


    pub_type: 杂志文章


    authors: Yang F,Shao C,Vedanarayanan V,Ehrlich M

    更新日期:2004-05-01 00:00:00

  • Outer kinetochore protein Dam1 promotes centromere clustering in parallel with Slk19 in budding yeast.

    abstract::A higher order organization of the centromeres in the form of clustering of these DNA loci has been observed in many organisms. While centromere clustering is biologically significant to achieve faithful chromosome segregation, the underlying molecular mechanism is yet to be fully understood. In budding yeast, a kinet...


    pub_type: 杂志文章


    authors: Mittal P,Chavan A,Trakroo D,Shah S,Ghosh SK

    更新日期:2019-06-01 00:00:00

  • Synaptonemal complex analysis of X-7 translocations in male mice. I. R3 and R5 quadrivalents.

    abstract::The synaptonemal complexes of surface-spread spermatocytes of mice heterozygous for one of two reciprocal translations (R3 and R5) between the X and chromosome 7 have been examined by light and electron microscopy (EM). The break points of R3 were determined to be at 70% of chromosome 7, as measured from the centromer...


    pub_type: 杂志文章


    authors: Ashley T,Russell LB,Cacheiro NL

    更新日期:1982-01-01 00:00:00

  • Identification of Porto-1, a new repeated sequence that localises close to the centromere of chromosome 2 of Drosophila melanogaster.

    abstract::We have used the polymerase chain reaction (PCR) technique to search the Drosophila melanogaster genome for the presence of sequences with homology to mammalian and yeast centromeric DNA. Using primers based on the human CENP-B box present in alpha-satellite DNA and part of the Saccharomyces cerevisiae CDEIII centrome...


    pub_type: 杂志文章


    authors: Coelho PA,Nurminsky D,Hartl D,Sunkel CE

    更新日期:1996-10-01 00:00:00

  • Comparative study of the function of polytene chromosomes in laboratory stocks of Drosophila melanogaster and the l(3)tl mutant (lethal tumorous larvae). II. Changes of banding pattern and transcriptional activity in the salivary chromosome of l(3)tl.

    abstract::The salivary chromosomes of the l(3)tl mutant of D. melanogaster are considerably thicker and shorter than those of normal larvae. In most nuclei, chromosome shortening is associated with morphological changes of two types. a) The bands lose their distinctive pattern and become loose. The chromosome appears as a granu...


    pub_type: 杂志文章


    authors: Zhimulev IF,Belyaeva ES,Lychev VA

    更新日期:1976-04-21 00:00:00

  • Sex chromosome pairing patterns in male mice of novel Sxr genotypes.

    abstract::The influence of the sex-reversal factor (Sxr) on X and Y chromosome pairing was examined by comparing males with "novel" and "standard" Sxr genotypes. The novel Sxr males were exceptional in carrying Sxr on their X rather than their Y chromosome, or homozygously on both their X and Y chromosomes, or on a Y chromosome...


    pub_type: 杂志文章


    authors: Tease C,Cattanach BM

    更新日期:1989-03-01 00:00:00

  • RNA polymerase II transcription and the functional organization of the mammalian cell nucleus.

    abstract::The study of RNA pol II-mediated transcription regulation has been dominated by molecular biological approaches. Although these methods continue to provide important insights, other approaches are required to insure against an oversimplified view of gene expression. Improvements in EM methods and the development of th...


    pub_type: 杂志文章,评审


    authors: Hendzel MJ,Bazett-Jones DP

    更新日期:1995-02-01 00:00:00

  • Anomalous development and differential DNA replication in the X-chromosome of a Drosophila hybrid.

    abstract::Male hybrids of the cross D. azteca X D. athabasca are larger (hybrid giant males) than their parents, whereas hybrid females are of the same size as the parental species. Microspectrophotometric measurements have shown that the larval polytene salivary gland chromosomes of hybrid giant males undergo one more endorepl...


    pub_type: 杂志文章


    authors: Meer B

    更新日期:1976-09-10 00:00:00

  • DNA representation of variegating heterochromatic P-element inserts in diploid and polytene tissues of Drosophila melanogaster.

    abstract::Position-effect variegation (PEV) is the mosaic expression of a euchromatic gene brought into juxtaposition with heterochromatin. Fourteen different transformed Drosophila melanogaster lines with variegating P-element inserts were used to examine the DNA levels of these transgenes. Insert sites include pericentric, te...


    pub_type: 杂志文章


    authors: Wallrath LL,Guntur VP,Rosman LE,Elgin SC

    更新日期:1996-04-01 00:00:00

  • A structural analysis of Balbiani ring dna sequences in Chironomus tentans.

    abstract::The Balbiani rings in the salivary gland polytene chromosomes of Chironomus tentans include the most active structural genes in this organ. Two of them (BR1 and BR2) contain repetitive sequences and are transcribed into giant RNA molecules. On Southern blots of restriction digests, we have identified fragments of geno...


    pub_type: 杂志文章


    authors: Degelmann A,Hollenberg CP

    更新日期:1981-01-01 00:00:00

  • An unstable minichromosome generates variegated oil yellow maize seedlings.

    abstract::An unstable minichromosome comprising part of the short arm of chromosome 10 of maize was recovered from an oil yellow variegated plant as a consequence of gamma irradiation of pollen. The cytological and gene dosage observations are consistent with the minichromosome being a partial isochromosome, which lags at mitot...


    pub_type: 杂志文章


    authors: Brock RD,Pryor AJ

    更新日期:1996-06-01 00:00:00

  • Robertsonian polymorphism in the marine gastropod, Nucella lapillus: advances in karyology using rDNA loci and NORs.

    abstract::Previous studies of the Robertsonian polymorphism in the Atlantic dog-whelk, Nucella lapillus (2n = 26-36), have been limited by the inability to identify unequivocally individual chromosomes in the karyotype. This species, as with many other marine invertebrates, has proven largely refractory to the standard (mammali...


    pub_type: 杂志文章


    authors: Pascoe PL,Patton SJ,Critcher R,Dixon DR

    更新日期:1996-03-01 00:00:00

  • Study of mitomycin C-induced chromosomal exchange.

    abstract::Mitomycin C-induced sister chromatic exchange and quadriradial formation were studied in chromosomes from Muntiacus muntjac fibroblasts and A9, a transformed mouse cell line. We present the first direct cytological evidence for the induction of true somatic recombination involving homologous chromosomes. Analysis of t...


    pub_type: 杂志文章


    authors: Huttner KM,Ruddle FH

    更新日期:1976-06-30 00:00:00

  • Incomplete sister chromatid separation of long chromosome arms.

    abstract::Chromosome segregation ensures the equal partitioning of chromosomes at mitosis. However, long chromosome arms may pose a problem for complete sister chromatid separation. In this paper we report on the analysis of cell division in primary cells from field vole Microtus agrestis, a species with 52 chromosomes includin...


    pub_type: 杂志文章


    authors: Rens W,Torosantucci L,Degrassi F,Ferguson-Smith MA

    更新日期:2006-12-01 00:00:00

  • Nucleolar targeting of coilin is regulated by its hypomethylation state.

    abstract::Coilin, a molecular marker for Cajal bodies (CBs), is a phosphoprotein that contains a cryptic nucleolar localization signal and multiple interacting domains, such as the RG-box. Post-translational symmetrical dimethylation of arginines on the coilin RG-box is required for the recruitment of the survival motor neuron ...


    pub_type: 杂志文章


    authors: Tapia O,Bengoechea R,Berciano MT,Lafarga M

    更新日期:2010-10-01 00:00:00

  • Chromatin structure in the unicellular algae Olisthodiscus luteus, Crypthecodinium cohnii and Peridiniun balticum.

    abstract::Isolated nuclei of the unicellular alga Olisthodiscus luteus, the uninucleate dinoflagellate Crypthecodinium cohnii and the binucleate dinoflagellate Peridinium balticum were lysed and deposited on grids by the microcentrifugation technique. The ultrastructure of the released chromatin fibers was compared to that of m...


    pub_type: 杂志文章


    authors: Rizzo PJ,Burghardt RC

    更新日期:1980-01-01 00:00:00

  • Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells.

    abstract::Mammalian heterochromatin proteins 1 (HP1alpha, HP1beta, and HP1gamma) are nonhistone proteins that interact in vitro with a set of proteins that play a role in chromatin silencing, transcription, and chromatin remodeling. Using antibodies specific for each HP1 isoform, we showed that they segregate in distinct nuclea...


    pub_type: 杂志文章


    authors: Minc E,Allory Y,Worman HJ,Courvalin JC,Buendia B

    更新日期:1999-08-01 00:00:00

  • Proportional polyploidization of 5S RNA genes in the ovary of Drosophila melanogaster mutants containing three 5S RNA gene loci.

    abstract::The 5S RNA gene content of polyploid cells of the ovary of Drosophila melanogaster has been compared in animals with two or three gene clusters. The amount of 5S RNA genes is exactly proportional to the number of gene clusters as determined by DNA-RNA filter hybridization. In contrast, the number of rDNA genes in endo...


    pub_type: 杂志文章


    authors: Renkawitz-Pohl R

    更新日期:1979-01-31 00:00:00

  • P1 clones from Drosophila melanogaster as markers to study the chromosomal evolution of Muller's A element in two species of the obscura group of Drosophila.

    abstract::Thirty P1 clones from the X chromosome (Muller's A element) of Drosophila melanogaster were cross-hybridized in situ to Drosophila subobscura and Drosophila pseudoobscura polytene chromosomes. An additional recombinant phage lambda Dsuby was also used as a marker. Twenty-three (77%) of the P1 clones gave positive hybr...


    pub_type: 杂志文章


    authors: Segarra C,Lozovskaya ER,Ribó G,Aguadé M,Hartl DL

    更新日期:1995-11-01 00:00:00

  • Organization of heterologous DNA inserts on the mouse meiotic chromosome core.

    abstract::With simultaneous immunofluorescence and fluorescent in situ hybridization, we have determined the organization of native and heterologous DNA sequences relative to the cores of meiotic prophase chromosomes. The normal chromatin organization is demonstrated with probes of mouse sequences: a cosmid probe that identifie...


    pub_type: 杂志文章


    authors: Heng HH,Tsui LC,Moens PB

    更新日期:1994-10-01 00:00:00

  • Sequence of DNA replication in 277 R- and Q-bands of human chromosomes using a BrdU treatment.

    abstract::Replication times for all important chromosome bands, of both types R and Q (277 structures) are analysed. The R-bands form a group of structures whose DNA replicates during the early S-phase, while the DNA situated in the Q-bands replicates during the late S-phase. There may not exist overlapping between replication ...


    pub_type: 杂志文章


    authors: Dutrillaux B,Couturier J,Richer CL,Viegas-Péquignot E

    更新日期:1976-10-12 00:00:00

  • Q- and C-bands in the metaphase chromosomes of Drosophila nasutoides.

    abstract::The large heterochromatic chromosome of Drosophila nasutoides reveals distinctive C- and Q-bands. The regions which are negative in C-banding appear positive in Q-banding. The isochromosomic nature of this chromosome and the locality of the satellite DNAs in this chromosome are discussed with respect to these banding ...


    pub_type: 杂志文章


    authors: Lee CS,Collins L

    更新日期:1977-04-27 00:00:00

  • Random segregation of sister chromatids in developing chick retinal cells demonstrated in vivo using the fluorescence plus Giemsa technique.

    abstract::Experiments were designed to test whether nonrandom segregation of sister chromatids at mitosis has a role in the production of cell diversity during embryogenesis, Segregation was examined in vivo in retinal cells from embryonic chicks. Chromatids were labelled with bromouracil and stained by the fluorescence plus Gi...


    pub_type: 杂志文章


    authors: Morris VB

    更新日期:1977-03-16 00:00:00

  • Cell cycle dependent distribution of a centrosomal antigen at the perinuclear MTOC or at the kinetochores of higher plant cells.

    abstract::Compelling evidence has been obtained in favour of the idea that the nuclear surface of higher plant cells is a microtubule-nucleating and/or organizing site (MTOC), in the absence of defined centrosomes. How these plant MTOC proteins are redistributed and function during the progression of the cell cycle remains enti...


    pub_type: 杂志文章


    authors: Schmit AC,Stoppin V,Chevrier V,Job D,Lambert AM

    更新日期:1994-09-01 00:00:00

  • Resolving ambiguities in the karyotype of domestic sheep (Ovis aries). II. G-, Q-, and R-banded idiograms, and chromosome-specific molecular markers.

    abstract::Internally consistent G-, Q- and R-banded karyotypes and idiograms for sheep chromosomes at the 422-band level of resolution are presented. These were derived by sequential Q- to G-staining, and sequential Q- to R-staining of prometaphase spreads prepared from sheep with normal and Robertsonian chromosomes. The fused ...


    pub_type: 杂志文章


    authors: Ansari HA,Maher DW,Pearce PD,Broad TE

    更新日期:1996-07-01 00:00:00

  • Mechanisms of chromosome banding. VIII. Hoechst 33258-DNA interaction.

    abstract::The interaction of Hoechst 33258 with DNA has been examined to help clarify the mechanisms of banding. 1. In agreement with previous studies Hoechst fluorescence is enhanced to a greater degree in AT-rich compared to GC-rich DNA. 2. Hoechst causes an increase in the DNA Tm which is greater at the higher AT content of ...


    pub_type: 杂志文章


    authors: Comings DE

    更新日期:1975-10-14 00:00:00

  • Primary and secondary nonrandom X chromosome inactivation in early female mouse embryos carrying Searle's translocation T(X; 16)16H.

    abstract::By means of a cytological technique involving 5-bromodeoxyuridine, acridine orange, and fluorescence microscopy, the asynchronously replicating, hence genetically inactivated, X chromosome was identified in 6- to 8-day embryos from female mice heterozygous for Searle's translocation T(X;16)16H (abbreviated as T16H) ma...


    pub_type: 杂志文章


    authors: Takagi N

    更新日期:1980-01-01 00:00:00

  • Two early replicated, developmentally controlled genes of Physarum display different patterns of DNA replication by two-dimensional agarose gel electrophoresis.

    abstract::The nature of replication origins in eukaryotic chromosomes has been examined in some detail only in yeast, Drosophila, and mammalian cells. We have used highly synchronous cultures of plasmodia of the myxomycete Physarum and two-dimensional agarose gel electrophoresis to examine replication of two developmentally con...


    pub_type: 杂志文章


    authors: Diller JD,Sauer HW

    更新日期:1993-09-01 00:00:00