Abstract:
:We have sequenced and analyzed 8.3 kb of sequence adjacent and distal to the human ribosomal DNA (rDNA); this distal sequence connects to the rDNA cluster just 4 kb upstream of the first promoter and is shared among the acrocentric chromosomes and, at least in part, it is also present in other primates. The sequence differs in character from that of the rDNA intergenic spacer (IGS) in that it does not contain long stretches of either polypyrimidine or polypurine. However, just like the IGS, it contains numerous repetitive elements, including retroposed fragments of 28S rRNA and large pieces of the IGS. In addition, we show that the rDNA clusters are not interrupted by other sequences and do not recombine with this distal segment.
journal_name
Chromosomajournal_title
Chromosomaauthors
Gonzalez IL,Sylvester JEdoi
10.1007/BF02510479subject
Has Abstractpub_date
1997-06-01 00:00:00pages
431-7issue
7-8eissn
0009-5915issn
1432-0886journal_volume
105pub_type
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