Abstract:
:Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and its cellular distribution dramatically changes during cell cycle progression. These localizations correlate with distinct functions. For example, during interphase, Ki-67 is required for normal cellular distribution of heterochromatin antigens and for the nucleolar association of heterochromatin. During mitosis, Ki-67 is essential for formation of the perichromosomal layer (PCL), a ribonucleoprotein sheath coating the condensed chromosomes. In this structure, Ki-67 acts to prevent aggregation of mitotic chromosomes. Here, we present an overview of functional roles of Ki-67 across the cell cycle and also describe recent experiments that clarify its role in regulating cell cycle progression in human cells.
journal_name
Chromosomajournal_title
Chromosomaauthors
Sun X,Kaufman PDdoi
10.1007/s00412-018-0659-8subject
Has Abstractpub_date
2018-06-01 00:00:00pages
175-186issue
2eissn
0009-5915issn
1432-0886pii
10.1007/s00412-018-0659-8journal_volume
127pub_type
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