Abstract：
:Chromosome fibers isolated from lymphocyte nuclei and prepared for electron microscopy by techniques designed to preserve their native structure have a distinctly knobby appearance, suggesting that DNA and protein are not distributed evenly along the fiber axis. Individual knobs (superbeads) are arranged in tandem and have an average diameter of about 200 A. Mild nuclease digestion of isolated nuclei releases apparent monomer superbeads that are composed of nucleohistone particles with the properties of nucleosomes. The kinetics of digestion indicate that the superbead is a discrete structural unit containing, on the average, about eight nucleosomes.
journal_name
Chromosomajournal_title
Chromosomaauthors
Hozier J,Renz M,Nehls Pdoi
10.1007/BF00327030subject
Has Abstractpub_date
1977-07-18 00:00:00pages
301-17issue
4eissn
0009-5915issn
1432-0886journal_volume
62pub_type
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