A glimmer of hope for diabetics?

abstract：:The bioeconomy concept is proliferating globally. However, the enabling roles of biotechnology may be getting sidelined in the strategies of some countries. A goal for engineering biology is alignment with the engineering design cycle to enable more rapid commercialization. This paper considers several policy options ...

journal_title：Trends in biotechnology

authors： Kitney R,Adeogun M,Fujishima Y,Goñi-Moreno Á,Johnson R,Maxon M,Steedman S,Ward S,Winickoff D,Philp J

更新日期：2019-09-01 00:00:00

abstract：:Although there is still some skepticism in the biological community regarding the value and significance of quantitative computational modeling, important steps are continually being taken to enhance its accessibility and predictive power. We view these developments as essential components of an emerging 'respectful m...

journal_title：Trends in biotechnology

authors： Tsigkinopoulou A,Baker SM,Breitling R

更新日期：2017-06-01 00:00:00

abstract：:Toxic organic compounds (xenobiotics) pose serious environmental and health risks worldwide. Biological treatment of these materials is severely constrained by their toxic and inhibitory nature and great care is required with respect to the rate at which they are provided to cells. The use of a second, distinct, organ...

journal_title：Trends in biotechnology

authors： Daugulis AJ

更新日期：2001-11-01 00:00:00

abstract：:We review published data on cell/gamete lyophilization. Most studies have utilized the same established protocols for cryopreservation (storage in liquid nitrogen) as for cell lyophilization (dehydration of frozen samples by water sublimation). Surveying natural lyoprotectants, we suggest trehalose and late embryogene...

journal_title：Trends in biotechnology

authors： Loi P,Iuso D,Czernik M,Zacchini F,Ptak G

更新日期：2013-12-01 00:00:00

abstract：:High-throughput genetic screens interfering with gene expression are invaluable tools to identify gene function and phenotype-to-genotype interactions. Implementing such screens in the laboratory is challenging, and the choice between currently available technologies based on RNAi and CRISPR/Cas9 (CRISPR-associated pr...

journal_title：Trends in biotechnology

authors： Schuster A,Erasimus H,Fritah S,Nazarov PV,van Dyck E,Niclou SP,Golebiewska A

更新日期：2019-01-01 00:00:00

abstract：:Higher fungi with greater than 70000 species are regarded as a rich source of various natural compounds including terpenoids, the production of which represents a wide range of interest in pharmaceutical and healthcare industries. This review summarizes the current knowledge of terpenoids synthesized by higher fungi, ...

journal_title：Trends in biotechnology

authors： Xiao H,Zhong JJ

更新日期：2016-03-01 00:00:00

abstract：:The general acceptance of bioremediation technology as an environmentally sound and economic treatment for hazardous waste requires the demonstration of its efficacy, reliability and predictability, as well as its advantages over conventional treatments. An effective monitoring design includes protocols for treatment-...

journal_title：Trends in biotechnology

authors： Heitzer A,Sayler GS

更新日期：1993-08-01 00:00:00

abstract：:The effective management of emerging insect-borne disease is dependent on the use of safe and efficacious chemical insecticides. Given the inherent ability of insects to develop resistance, it is essential to propose innovative strategies because insecticides remain the most important element of integrated approaches ...

journal_title：Trends in biotechnology

authors： Lapied B,Pennetier C,Apaire-Marchais V,Licznar P,Corbel V

更新日期：2009-04-01 00:00:00

abstract：:In vitro selection from molecular libraries has rapidly come of age as a protein-engineering tool. Dramatic increases in protein affinity can be engineered using phage-display libraries, and specific antibodies can be selected directly from a single 'naïve' library of their genes. Repertoires of small molecules are a ...

journal_title：Trends in biotechnology

authors： Clackson T,Wells JA

更新日期：1994-05-01 00:00:00

abstract：:Spheroids provide a 3D environment with intensive cell-cell contacts. As a result of their excellent regenerative properties and rapid progress in their high-throughput production, spheroids are increasingly suggested as building blocks for tissue engineering. In this review, we focus on innovative biotechnological ap...

journal_title：Trends in biotechnology

authors： Laschke MW,Menger MD

更新日期：2017-02-01 00:00:00

abstract：:A major goal of material science is to produce hierarchical materials that are ordered on all length scales, from the molecular (1-100 A) via the nano (10-100 nm) to the meso (1-100 microm). In these materials, the larger-scale properties can be controlled by choosing molecular characteristics. Methods developed to pr...

journal_title：Trends in biotechnology

authors： Dan N

更新日期：2000-09-01 00:00:00

abstract：:Clustered regularly interspaced short palindromic repeats (CRISPR)-mediated manipulation of genomic information is becoming more versatile by combining nuclease-deficient CRISPR systems with a wide variety of effectors including base-editing deaminases, transcriptional regulators, and epigenetic modifiers. The program...

journal_title：Trends in biotechnology

authors： Mitsunobu H,Teramoto J,Nishida K,Kondo A

更新日期：2017-10-01 00:00:00

abstract：:Neurodegenerative diseases are of major socioeconomic importance and represent an enormous challenge for the scientific and medical communities. Advances in molecular genetics during the past decade have begun to provide approaches for the establishment of animal models for these disorders using transgenic technology....

journal_title：Trends in biotechnology

authors： Theuring F,Thunecke M,Kosciessa U,Turner JD

更新日期：1997-08-01 00:00:00

abstract：:Techniques to enable direct communication between the brain and computers/machines, such as the brain-computer interface (BCI) or the brain-machine interface (BMI), are gaining momentum in the neuroscientific realm, with potential applications ranging from medicine to general consumer electronics. Noninvasive BCI tech...

journal_title：Trends in biotechnology

authors： Min BK,Marzelli MJ,Yoo SS

更新日期：2010-11-01 00:00:00

abstract：:Breath-based metabolomics (breathomics) is an exciting developing area of biotechnology that centers on the capture, identification, and quantification of volatile organic compound (VOC) patterns in human breath and their utilization as tools in the diagnosis of a broad spectrum of medical problems. With the age of pe...

journal_title：Trends in biotechnology

authors： Rattray NJ,Hamrang Z,Trivedi DK,Goodacre R,Fowler SJ

更新日期：2014-10-01 00:00:00

abstract：:Low production cost is a key factor driving the development of plants and plant tissue cultures for the synthesis of therapeutic and other foreign proteins. Because product yield and concentration exert a major influence on process economics, improving foreign protein accumulation is crucial for enhancing the commerci...

journal_title：Trends in biotechnology

authors： Doran PM

更新日期：2006-09-01 00:00:00

abstract：:Musculoskeletal diseases are increasing the prevalence of physical disability worldwide. Within the body, musculoskeletal soft and hard tissues integrate through specific multitissue transitions, allowing for body movements. Owing to their unique compositional and structural gradients, injuries challenge the native in...

journal_title：Trends in biotechnology

authors： Calejo I,Costa-Almeida R,Reis RL,Gomes ME

更新日期：2020-01-01 00:00:00

abstract：:Vibrational spectroscopy using both infrared and Raman spectroscopies has been used in recent years with the aim to aid clinicians in disease diagnosis. More recently, these techniques have been applied to study stem cell differentiation and to determine stem cell presence in tissues. These studies have demonstrated t...

journal_title：Trends in biotechnology

authors： Sulé-Suso J,Forsyth NR,Untereiner V,Sockalingum GD

更新日期：2014-05-01 00:00:00

abstract：:We discuss the general properties of optical imaging in three-dimensional object domains from an information-theoretic standpoint, expressing system performance in terms of imaging mutual information (IMI). We use IMI to characterize volume holographic imaging, a new optical imaging method with depth discrimination ca...

journal_title：Trends in biotechnology

authors： Barbastathis G,Sinha A

更新日期：2001-10-01 00:00:00

abstract：:Direct delivery of purified Cas9 protein with guide RNA into plant cells, as opposed to plasmid-mediated delivery, displays high efficiency and reduced off-target effects. Following regeneration from edited cells, the ensuing plant is also likely to bypass genetically modified organism (GMO) legislation as the genome ...

journal_title：Trends in biotechnology

authors： Kanchiswamy CN,Malnoy M,Velasco R,Kim JS,Viola R

更新日期：2015-09-01 00:00:00

abstract：:Infrared spectroscopy and microscopy have heralded a period of rapid advances in tissue and cellular characterization during the past decade. However, vibrational spectroscopy is still an analytical tool that is neither familiar nor understood in the medical environment. For many years this field has been mainly drive...

journal_title：Trends in biotechnology

authors： Dumas P,Sockalingum GD,Sulé-Suso J

更新日期：2007-01-01 00:00:00

abstract：:The spatial distribution of molecules and cells is fundamental to understanding biological systems. Traditionally, microscopies based on electromagnetic waves such as visible light have been used to localize cellular components by direct visualization. However, these techniques suffer from limitations of transmissibil...

journal_title：Trends in biotechnology

authors： Boulgakov AA,Ellington AD,Marcotte EM

更新日期：2020-02-01 00:00:00

abstract：:The announcement that the European Union (EU) had reached an agreement allowing Member States (MS) to ban genetically modified (GM) crops confirms that the EU has chosen to ignore the food security challenge issued to the world by the Food and Agriculture Organization of the United Nations (FAO) in 2009. The FAO sugge...

journal_title：Trends in biotechnology

authors： Smyth SJ,Phillips PWB,Kerr WA

更新日期：2016-07-01 00:00:00

abstract：:Nanomaterials have been developed for many biomedical applications, including medical imaging, drug delivery, and antimicrobial coatings. Intriguingly, nanoparticles can display 'enzyme-like' activity and have been explored as alternatives to natural enzymes in several industrial and energy-related applications. Recen...

journal_title：Trends in biotechnology

authors： Cormode DP,Gao L,Koo H

更新日期：2018-01-01 00:00:00

abstract：:Cyanobacteria promise to be an important industrial platform for the production of a variety of biobased products such as fuels, plastics, and isoprenoids. Recent advances in synthetic biology have resulted in various cyanobacterial strain improvements. Nevertheless, these new strains are still hampered by product inh...

journal_title：Trends in biotechnology

authors： van den Berg C,Eppink MHM,Wijffels RH

更新日期：2019-05-01 00:00:00

abstract：:Carotenoids are antioxidants with considerable pharmaceutical potential. More than 600 carotenoid structures are known but their availability is limited owing to practical difficulties associated with chemical synthesis and isolation from microorganisms or plant tissue. To overcome some of these problems, heterologous...

journal_title：Trends in biotechnology

authors： Sandmann G,Albrecht M,Schnurr G,Knörzer O,Böger P

更新日期：1999-06-01 00:00:00

abstract：:Building robust manufacturing processes from biological components is a task that is highly complex and requires sophisticated tools to describe processes, inputs, and measurements and administrate management of knowledge, data, and materials. We argue that for bioengineering to fully access biological potential, it w...

journal_title：Trends in biotechnology

authors： Sadowski MI,Grant C,Fell TS

更新日期：2016-03-01 00:00:00

abstract：:Gene expression noise is a significant source of phenotypic heterogeneity in otherwise identical populations of cells. Phenotypic heterogeneity can cause reversible drug resistance in diseased cells, and thus a better understanding of its origins might improve treatment strategies. In eukaryotes, data strongly suggest...

journal_title：Trends in biotechnology

authors： Miller-Jensen K,Dey SS,Schaffer DV,Arkin AP

更新日期：2011-10-01 00:00:00

abstract：:Microbes are present at every crime scene and have been used as physical evidence for over a century. Advances in DNA sequencing and computational approaches have led to recent breakthroughs in the use of microbiome approaches for forensic science, particularly in the areas of estimating postmortem intervals (PMIs), l...

journal_title：Trends in biotechnology

authors： Metcalf JL,Xu ZZ,Bouslimani A,Dorrestein P,Carter DO,Knight R

更新日期：2017-09-01 00:00:00

abstract：:Opinions on what synthetic biology actually is range from a natural extension of genetic engineering to a new manufacturing paradigm. It offers, for the first time in the life sciences, rational design and engineering standardisation. It could address problems across a broad spectrum of human concerns, including energ...

journal_title：Trends in biotechnology

authors： Philp JC,Ritchie RJ,Allan JE

更新日期：2013-05-01 00:00:00