A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering.

abstract：:Molecular imaging permits non-invasive visualization and measurement of molecular and cell biology in living subjects, thereby complementing conventional anatomical imaging. Herein, we review the emerging application of molecular imaging for the study of musculoskeletal biology. Utilizing mainly bioluminescence and fl...

journal_title：Trends in biotechnology

authors： Reumann MK,Weiser MC,Mayer-Kuckuk P

更新日期：2010-02-01 00:00:00

abstract：:Aroma emissions from living cells can provide valuable information about the metabolic and physiological condition of those cells. Electronic noses are chemical gas-sensor arrays that use artificial neural network models to evaluate aromas. They can interpret the complex aroma information emitted from cultures of bact...

journal_title：Trends in biotechnology

authors： Bachinger T,Mandenius CF

更新日期：2000-12-01 00:00:00

abstract：:One of the goals of synthetic biology is to build regulatory circuits that control cell behavior, for both basic research purposes and biomedical applications. The ability to build transcriptional regulatory devices depends on the availability of programmable, sequence-specific, and effective synthetic transcription f...

journal_title：Trends in biotechnology

authors： Jusiak B,Cleto S,Perez-Piñera P,Lu TK

更新日期：2016-07-01 00:00:00

abstract：:The free-radical gas nitric oxide (NO) plays an important role in a wide and diverse range of physiological processes. As progress is made in understanding the biological function of NO, there is growing interest in the possibility that inhibitors of NO synthase (NOS) may be of clinical use in the therapy of certain d...

journal_title：Trends in biotechnology

authors： Ogden JE,Moore PK

更新日期：1995-02-01 00:00:00

abstract：:The general acceptance of bioremediation technology as an environmentally sound and economic treatment for hazardous waste requires the demonstration of its efficacy, reliability and predictability, as well as its advantages over conventional treatments. An effective monitoring design includes protocols for treatment-...

journal_title：Trends in biotechnology

authors： Heitzer A,Sayler GS

更新日期：1993-08-01 00:00:00

abstract：:Novel therapeutic strategies that promote wound healing seek to mimic the response of the body to wounding, to regenerate rather than repair injured tissues. Many synthetic or natural biomaterials have been developed for this purpose and are used to deliver wound therapeutics in a controlled manner that prevents unwan...

journal_title：Trends in biotechnology

authors： Andreadis ST,Geer DJ

更新日期：2006-07-01 00:00:00

abstract：:Antimicrobial resistance (AMR) has developed into a huge threat to global health, and reducing it is an urgent priority for public health authorities. The importance of a healthy and balanced gut microbiome has been identified as a key protective factor against AMR development, but this can be significantly affected b...

journal_title：Trends in biotechnology

authors： Kelly SA,Rodgers AM,O'Brien SC,Donnelly RF,Gilmore BF

更新日期：2020-04-01 00:00:00

abstract：:Diabetes affects 150 million people worldwide and results from abnormal function of pancreatic islets. The scarcity of human tissue donors has focused interest in developing renewable sources of insulin-producing cells appropriate for engraftment. Advances in stem cell technology and transdifferentiation techniques ha...

journal_title：Trends in biotechnology

authors： Orive Arroyo G,Hernánedez RM,Gascón AR,Igartua M,Pedraz JL

更新日期：2003-07-01 00:00:00

abstract：:There is a need for techniques that ensure antibiotic removal in anaerobic digesters for robust methane production. In this article, we discuss recent strategies for enhanced antibiotic removal from swine wastewater and offer insights on anaerobic digestion (AD) process design for improved antibiotic removal. ...

journal_title：Trends in biotechnology

authors： Zhou Q,Li X,Wu S,Zhong Y,Yang C

更新日期：2021-01-01 00:00:00

abstract：:We review published data on cell/gamete lyophilization. Most studies have utilized the same established protocols for cryopreservation (storage in liquid nitrogen) as for cell lyophilization (dehydration of frozen samples by water sublimation). Surveying natural lyoprotectants, we suggest trehalose and late embryogene...

journal_title：Trends in biotechnology

authors： Loi P,Iuso D,Czernik M,Zacchini F,Ptak G

更新日期：2013-12-01 00:00:00

abstract：:Anywhere water is in the liquid state, bacteria will exist as biofilms, which are complex communities of cells that are cemented together. Although frequently associated with disease and biofouling, biofilms are also important for engineering applications, such as bioremediation, biocatalysis and microbial fuel cells....

journal_title：Trends in biotechnology

authors： Wood TK,Hong SH,Ma Q

更新日期：2011-02-01 00:00:00

abstract：:Molecularly imprinted polymers (MIPs) are prepared by creating a three-dimensional polymeric matrix around a template molecule. After the matrix is removed, complementary cavities with respect to shape and functional groups remain. MIPs have been produced for applications in in vitro diagnostics, therapeutics and sepa...

journal_title：Trends in biotechnology

authors： Poma A,Turner AP,Piletsky SA

更新日期：2010-12-01 00:00:00

abstract：:Chronic diseases, particularly malignancies and immune-mediated inflammatory diseases (IMIDs), are a challenging frontier for clinical diagnosis and treatment, as well as for biomedical research. Current treatment regimens are frequently insufficient and thus new treatment strategies are needed. Novel therapies for di...

journal_title：Trends in biotechnology

authors： Tarner IH,Müller-Ladner U,Fathman CG

更新日期：2004-06-01 00:00:00

abstract：:Microbial contamination of polymer surfaces has become a significant challenge in domestic, industrial, and biomedical applications. Recent progress in our understanding of how topographical features of different length scales can be used to effectively and selectively control the attachment and proliferation of diffe...

journal_title：Trends in biotechnology

authors： Nguyen DHK,Bazaka O,Bazaka K,Crawford RJ,Ivanova EP

更新日期：2020-05-01 00:00:00

abstract：:Building robust manufacturing processes from biological components is a task that is highly complex and requires sophisticated tools to describe processes, inputs, and measurements and administrate management of knowledge, data, and materials. We argue that for bioengineering to fully access biological potential, it w...

journal_title：Trends in biotechnology

authors： Sadowski MI,Grant C,Fell TS

更新日期：2016-03-01 00:00:00

abstract：:Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms...

journal_title：Trends in biotechnology

authors： Cardenas ME,Sanfridson A,Cutler NS,Heitman J

更新日期：1998-10-01 00:00:00

abstract：:Many pathogens have the ability to vary the antigenic composition of surface-associated antigens. Often, this variation is mediated by the regulation of gene expression. By varying its antigenicity, the pathogen is able to avoid host immune responses more efficiently; however, this makes the design of vaccines against...

journal_title：Trends in biotechnology

authors： Maskell D,Frankel G,Dougan G

更新日期：1993-12-01 00:00:00

abstract：:Carotenoids are one of the most diverse classes of natural compounds. Plant carotenoids are composed of a C40 isoprenoid skeleton with or without epoxy, hydroxy and keto groups. They have fundamental roles in human nutrition as antioxidants and vitamin A precursors and their consumption is increasingly associated with...

journal_title：Trends in biotechnology

authors： Giuliano G,Tavazza R,Diretto G,Beyer P,Taylor MA

更新日期：2008-03-01 00:00:00

abstract：:Step by step, the components of an artificial form of cellular life are being assembled by researchers. Lipid vesicles the size of small bacteria can be prepared and under certain conditions are able to grow and divide, then grow again. Polymerase enzymes encapsulated in the vesicles can synthesize RNA from externally...

journal_title：Trends in biotechnology

authors： Deamer D

更新日期：2005-07-01 00:00:00

abstract：:Metabolomics embraces several strategies that aim to quantify cell metabolites in order to increase our understanding of how metabolite levels and interactions influence phenotypes. Metabolic footprinting represents a niche within metabolomics, because it focuses on the analysis of extracellular metabolites. Although ...

journal_title：Trends in biotechnology

authors： Mapelli V,Olsson L,Nielsen J

更新日期：2008-09-01 00:00:00

abstract：:The use of antibodies or antibody fragments for targeting tumors (either for tumor imaging or as carriers for drugs or toxins), has encountered problems of clearance, and non-specific or inefficient binding in clinical trials. A novel approach, linking two antibody variable fragments (Fvs), with a short peptide to gen...

journal_title：Trends in biotechnology

authors： Bird RE,Walker BW

更新日期：1991-04-01 00:00:00

abstract：:Molecular systems in which fluorescence switches between 'on' and 'off' states when driven by chemical stimuli can be designed according to a few principles. The photochemical mechanisms examined are photoinduced electron transfer, internal charge transfer and excimer formation, with emphasis on the first category. Th...

journal_title：Trends in biotechnology

authors： de Silva AP,Fox DB,Moody TS,Weir SM

更新日期：2001-01-01 00:00:00

abstract：:Atherosclerosis and heart disease are still the leading causes of morbidity and mortality worldwide. The lack of suitable autologous grafts has produced a need for artificial grafts but the patency of such grafts is limited compared to natural materials. Tissue engineering, whereby living tissue replacements can be co...

journal_title：Trends in biotechnology

authors： Sales KM,Salacinski HJ,Alobaid N,Mikhail M,Balakrishnan V,Seifalian AM

更新日期：2005-09-01 00:00:00

abstract：:Colloidal gas aphrons are microbubbles encapsulated by surfactant multilayers. They provide a large interfacial area to adsorb charged and/or hydrophobic molecules; the extent and mechanism of the adsorption depends on the surfactant multilayer. The physical properties of colloidal gas aphrons have recently been chara...

journal_title：Trends in biotechnology

authors： Jauregi P,Varley J

更新日期：1999-10-01 00:00:00

abstract：:Small interfering RNAs (siRNAs) have been shown to effectively downregulate gene expression in human cells, giving them potential to eradicate disease. Prospects for clinical applications are discussed in this review, along with an overview of recent history and our current understanding of siRNAs used for therapeutic...

journal_title：Trends in biotechnology

authors： Lares MR,Rossi JJ,Ouellet DL

更新日期：2010-11-01 00:00:00

abstract：:In vitro selection from molecular libraries has rapidly come of age as a protein-engineering tool. Dramatic increases in protein affinity can be engineered using phage-display libraries, and specific antibodies can be selected directly from a single 'naïve' library of their genes. Repertoires of small molecules are a ...

journal_title：Trends in biotechnology

authors： Clackson T,Wells JA

更新日期：1994-05-01 00:00:00

abstract：:The lantibiotics are a unique class of bacterium-derived peptide antibiotics, all of which contain the rare amino acid lanthionine, as well as a number of other nonprotein amino acids. Unlike most other peptide antibiotics, lantibiotics are produced on the ribosome as a prepeptide, and a series of post-translational m...

journal_title：Trends in biotechnology

authors： Jack RW,Sahl HG

更新日期：1995-07-01 00:00:00

abstract：:Attempts through somatic cell nuclear transfer to expand wild populations that have shrunk to critical numbers is a logical extension of the successful cloning of mammals. However, although the first mammal was cloned 10 years ago, nuclear reprogramming remains phenomenological, with abnormal gene expression and epige...

journal_title：Trends in biotechnology

authors： Loi P,Galli C,Ptak G

更新日期：2007-05-01 00:00:00

abstract：:Small molecules are defined as low molecular weight organic compounds (typically <1000 Da), which could be either natural or artificial. Because established imaging methods are not able to selectively detect the positions, concentrations and structures of small molecules in biological samples, new methods have been de...

journal_title：Trends in biotechnology

authors： Svatos A

更新日期：2010-08-01 00:00:00

abstract：:The extensive use of chemical insecticides for insect pest management has resulted in insecticide resistance now being recorded in >500 species of insects and mites. Although gut-active toxins such as those derived from Bacillus thuringiensis (Bt) have been successfully used for insect pest management, a diverse range...

journal_title：Trends in biotechnology

authors： Bonning BC,Chougule NP

更新日期：2014-02-01 00:00:00