Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation.

abstract：:The presence of Set2-mediated methylation of H3K36 (K36me) correlates with transcription frequency throughout the yeast genome. K36me targets the Rpd3S complex to deacetylate transcribed regions and suppress cryptic transcription initiation at certain genes. Here, using a genome-wide approach, we report that the Set2-...

journal_title：Genes & development

authors： Li B,Gogol M,Carey M,Pattenden SG,Seidel C,Workman JL

更新日期：2007-06-01 00:00:00

abstract：:Translation initiation factor 2 (eIF2) bound to GTP transfers the initiator methionyl tRNA to the 40S ribosomal subunit. The eIF5 stimulates GTP hydrolysis by the eIF2/GTP/Met-tRNA(i)(Met) ternary complex on base-pairing between Met-tRNA(i)(Met) and the start codon. The eIF2, eIF5, and eIF1 all have been implicated in...

journal_title：Genes & development

authors： Asano K,Clayton J,Shalev A,Hinnebusch AG

更新日期：2000-10-01 00:00:00

abstract：:We hypothesized that basic helix-loop-helix (bHLH) MIST1 (BHLHA15) is a "scaling factor" that universally establishes secretory morphology in cells that perform regulated secretion. Here, we show that targeted deletion of MIST1 caused dismantling of the secretory apparatus of diverse exocrine cells. Parietal cells (PC...

journal_title：Genes & development

authors： Lo HG,Jin RU,Sibbel G,Liu D,Karki A,Joens MS,Madison BB,Zhang B,Blanc V,Fitzpatrick JA,Davidson NO,Konieczny SF,Mills JC

更新日期：2017-01-15 00:00:00

abstract：:Histone deacetylase 3 (HDAC3) is one of four members of the human class I HDACs that regulates gene expression by deacetylation of histones and nonhistone proteins. Early studies have suggested that HDAC3 activity is regulated by association with the corepressors N-CoR and SMRT. Here we demonstrate that, in addition t...

journal_title：Genes & development

authors： Zhang X,Ozawa Y,Lee H,Wen YD,Tan TH,Wadzinski BE,Seto E

更新日期：2005-04-01 00:00:00

abstract：:Cell fates in the optic neuroepithelium are determined by the combinational action of homeotic transcription factors. One of these is Vax2, a homeodomain protein that ventralizes the vertebrate eye field by repressing transcription of the Pax6 gene. We find that Vax2 shuttles between the nucleus and cytoplasm as a fun...

journal_title：Genes & development

authors： Kim JW,Lemke G

更新日期：2006-10-15 00:00:00

abstract：:The subdivision of the Drosophila body into distinct terminal and central domains depends on the torso (tor) protein, a putative receptor tyrosine kinase that is active at both ends of the early embryo. We show that the tor protein is uniformly expressed along the surface membrane of early embryos despite its localize...

journal_title：Genes & development

authors： Casanova J,Struhl G

更新日期：1989-12-01 00:00:00

abstract：:TP53 is the most frequently mutated gene in human cancer. Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that contribute to metastasis, but the mechanisms mediating these functions remain poorly defined in vivo. To elucidate how mutant p53 GOF drives metastasis, we developed a traceable som...

journal_title：Genes & development

authors： Pourebrahim R,Zhang Y,Liu B,Gao R,Xiong S,Lin PP,McArthur MJ,Ostrowski MC,Lozano G

更新日期：2017-09-15 00:00:00

abstract：:Asymmetric localization of cell fate determinants is a crucial step in neuroblast asymmetric divisions. Whereas several protein kinases have been shown to mediate this process, no protein phosphatase has so far been implicated. In a clonal screen of larval neuroblasts we identified the evolutionarily conserved Protein...

journal_title：Genes & development

authors： Sousa-Nunes R,Chia W,Somers WG

更新日期：2009-02-01 00:00:00

abstract：:The activity of the SCF(skp2) E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a complex phenotype including changes in cell size and DNA content as well as severe proliferation defects. Here we show...

journal_title：Genes & development

authors： Kossatz U,Dietrich N,Zender L,Buer J,Manns MP,Malek NP

更新日期：2004-11-01 00:00:00

abstract：:The widespread class of RNA viruses that utilize internal ribosome entry sites (IRESs) for translation include poliovirus and Hepatitis C virus. To identify host factors required for IRES-dependent translation and viral replication, we performed a genome-wide RNAi screen in Drosophila cells infected with Drosophila C ...

journal_title：Genes & development

authors： Cherry S,Doukas T,Armknecht S,Whelan S,Wang H,Sarnow P,Perrimon N

更新日期：2005-02-15 00:00:00

abstract：:In murine plasmacytoma and human Burkitt's lymphoma cells, one allele of c-myc is translocated into one of the immunoglobulin loci, resulting in a characteristic pattern of deregulated c-myc transcription. Translocation events between c-myc and the IgH locus segregate c-myc and the IgH intron enhancer to different rec...

journal_title：Genes & development

authors： Madisen L,Groudine M

更新日期：1994-09-15 00:00:00

abstract：:In mitosis, the spindle checkpoint protein Mad2 averts aneuploidy by delaying anaphase onset until chromosomes align. Here we show that depletion of Mad2 in meiosis I mouse oocytes induced an increased incidence of aneuploidy. Proteolysis of cyclin B and securin commenced earlier in Mad2-depleted oocytes, resulting in...

journal_title：Genes & development

authors： Homer HA,McDougall A,Levasseur M,Yallop K,Murdoch AP,Herbert M

更新日期：2005-01-15 00:00:00

abstract：:Chromatin reorganization is essential for transcriptional control by sequence-specific transcription factors. However, the molecular link between transcriptional control and chromatin reconfiguration remains unclear. By colocalization of the nuclear ecdysone receptor (EcR) on the ecdysone-induced puff in the salivary ...

journal_title：Genes & development

authors： Sawatsubashi S,Murata T,Lim J,Fujiki R,Ito S,Suzuki E,Tanabe M,Zhao Y,Kimura S,Fujiyama S,Ueda T,Umetsu D,Ito T,Takeyama K,Kato S

更新日期：2010-01-15 00:00:00

abstract：:The Swi/Snf chromatin remodeling complex functions to alter nucleosome positions by either sliding nucleosomes on DNA or the eviction of histones. The presence of histone acetylation and activator-dependent recruitment and retention of Swi/Snf is important for its efficient function. It is not understood, however, why...

journal_title：Genes & development

authors： Dutta A,Gogol M,Kim JH,Smolle M,Venkatesh S,Gilmore J,Florens L,Washburn MP,Workman JL

更新日期：2014-10-15 00:00:00

abstract：:Multiple congenital disorders often present complex phenotypes, but how the mutation of individual genetic factors can lead to multiple defects remains poorly understood. In the present study, we used human neuroepithelial (NE) cells and CHARGE patient-derived cells as an in vitro model system to identify the function...

journal_title：Genes & development

authors： Chai M,Sanosaka T,Okuno H,Zhou Z,Koya I,Banno S,Andoh-Noda T,Tabata Y,Shimamura R,Hayashi T,Ebisawa M,Sasagawa Y,Nikaido I,Okano H,Kohyama J

更新日期：2018-01-15 00:00:00

abstract：:Deregulated expression of the c-myc proto-oncogene can lead to apoptosis under certain physiological conditions. By introducing a conditionally active Myc allele into primary embryo fibroblasts null for p53, and into fibroblasts without endogenous p53 expression but ectopically expressing a temperature-sensitive p53 a...

journal_title：Genes & development

authors： Wagner AJ,Kokontis JM,Hay N

更新日期：1994-12-01 00:00:00

abstract：:The liver is a unique organ with a remarkably high potential to regenerate upon injuries. In severely damaged livers where hepatocyte proliferation is impaired, facultative liver progenitor cells (LPCs) proliferate and are assumed to contribute to regeneration. An expansion of LPCs is often observed in patients with v...

journal_title：Genes & development

authors： Takase HM,Itoh T,Ino S,Wang T,Koji T,Akira S,Takikawa Y,Miyajima A

更新日期：2013-01-15 00:00:00

abstract：:Cell differentiation is essential for the development of multicellular organisms. In flowering plants, the haploid male gametophytes (pollen grains) are generated in the anther from reproductive cells called microsporocytes. Several types of somatic cells ensure successful pollen development, and thus reproduction. Ho...

journal_title：Genes & development

authors： Zhao DZ,Wang GF,Speal B,Ma H

更新日期：2002-08-01 00:00:00

abstract：:Alteration of nucleosomes by ATP-dependent remodeling complexes represents a critical step in the regulation of transcription. The human SWI/SNF (hSWI/SNF) family is composed of complexes that contain either Brg1 or hBrm as the central ATPase; however, these separate complexes have not been compared functionally. Here...

journal_title：Genes & development

authors： Sif S,Saurin AJ,Imbalzano AN,Kingston RE

更新日期：2001-03-01 00:00:00

abstract：:Two retrovirus promoter trap vectors (U3His and U3Neo) have been used to disrupt genes expressed in totipotent murine embryonal stem (ES) cells. Selection in L-histidinol or G418 produced clones in which the coding sequences for histidinol-dehydrogenase or neomycin-phosphotransferase were fused to sequences in or near...

journal_title：Genes & development

authors： von Melchner H,DeGregori JV,Rayburn H,Reddy S,Friedel C,Ruley HE

更新日期：1992-06-01 00:00:00

abstract：:Hepatitis B virus (HBV) infects humans and causes a wide range of clinical manifestations, from acute hepatitis to hepatocellular carcinoma (HCC). The HBV genome contains multiple promoters with gene expression regulated predominantly by the cellular transcription initiation machinery. Accordingly, the HBV-encoded pX,...

journal_title：Genes & development

authors： Haviv I,Matza Y,Shaul Y

更新日期：1998-04-15 00:00:00

abstract：:Inactivation of cyclin B-Cdc2 kinase at the exit from M phase depends on the specific proteolysis of the cyclin B subunit, whereas the Cdc2 subunit remains present at nearly constant levels throughout the cell cycle. It is unknown how Cdc2 escapes degradation when cyclin B is destroyed. In Xenopus egg extracts that re...

journal_title：Genes & development

authors： Nishiyama A,Tachibana K,Igarashi Y,Yasuda H,Tanahashi N,Tanaka K,Ohsumi K,Kishimoto T

更新日期：2000-09-15 00:00:00

abstract：:Codon usage bias is a universal feature of all genomes, but its in vivo biological functions in animal systems are not clear. To investigate the in vivo role of codon usage in animals, we took advantage of the sensitivity and robustness of the Drosophila circadian system. By codon-optimizing parts of Drosophila period...

journal_title：Genes & development

authors： Fu J,Murphy KA,Zhou M,Li YH,Lam VH,Tabuloc CA,Chiu JC,Liu Y

更新日期：2016-08-01 00:00:00

abstract：:DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes have been identified in yeast and mammalian cells. Loop formation is transcription-dependent and requires components of the pre-mRNA 3'-end processing machinery. Here we report that looping at the yeast GAL10 gene persi...

journal_title：Genes & development

authors： Lainé JP,Singh BN,Krishnamurthy S,Hampsey M

更新日期：2009-11-15 00:00:00

abstract：:Coliphage N4 is a double-stranded DNA virus that requires the sequential activity of three different RNA polymerases during infection. The N4 virion RNA polymerase, which is carried in the virion and is injected with the DNA at the start of infection, is responsible for the synthesis of N4 early RNAs. In vitro, the vi...

journal_title：Genes & development

authors： Markiewicz P,Malone C,Chase JW,Rothman-Denes LB

更新日期：1992-10-01 00:00:00

abstract：:Janus kinase 2 (JAK2) is a central kinase in hematopoietic stem/progenitor cells (HSPCs), and its uncontrolled activation is a prominent oncogenic driver of hematopoietic neoplasms. However, molecular mechanisms underlying the regulation of JAK2 have remained elusive. Here we report that the Casitas B-cell lymphoma (C...

journal_title：Genes & development

authors： Lv K,Jiang J,Donaghy R,Riling CR,Cheng Y,Chandra V,Rozenova K,An W,Mohapatra BC,Goetz BT,Pillai V,Han X,Todd EA,Jeschke GR,Langdon WY,Kumar S,Hexner EO,Band H,Tong W

更新日期：2017-05-15 00:00:00

abstract：:The formation of the apical ectodermal ridge (AER) is critical for the distal outgrowth and patterning of the vertebrate limb. Recent work in the chick has demonstrated that interplay between the Wnt and Fgf signaling pathways is essential in the limb mesenchyme and ectoderm in the establishment and perhaps the mainte...

journal_title：Genes & development

authors： Barrow JR,Thomas KR,Boussadia-Zahui O,Moore R,Kemler R,Capecchi MR,McMahon AP

更新日期：2003-02-01 00:00:00

abstract：:DNA replication remains unfinished in many Drosophila polyploid cells, which harbor disproportionately fewer copies of late-replicating chromosomal regions. By analyzing paired-end high-throughput sequence data from polytene larval salivary gland cells, we define 112 underreplicated (UR) euchromatic regions 60-480 kb ...

journal_title：Genes & development

authors： Yarosh W,Spradling AC

更新日期：2014-08-15 00:00:00

abstract：:The conserved RCN family of proteins can bind and directly regulate calcineurin, a Ca(2+)-activated protein phosphatase involved in immunity, heart growth, muscle development, learning, and other processes. Whereas high levels of RCNs can inhibit calcineurin signaling in fungal and animal cells, RCNs can also stimulat...

journal_title：Genes & development

authors： Hilioti Z,Gallagher DA,Low-Nam ST,Ramaswamy P,Gajer P,Kingsbury TJ,Birchwood CJ,Levchenko A,Cunningham KW

更新日期：2004-01-01 00:00:00

abstract：:The assembly of activated RNA polymerase II (pol II) transcription complexes has been investigated by assaying whether pre-assembly of intermediate complexes reduces the extended time required for start-site melting. The results show that a closed complex requiring factors IIA, IID, and the acidic activator GAL4-AH fo...

journal_title：Genes & development

authors： Wang W,Gralla JD,Carey M

更新日期：1992-09-01 00:00:00