Biosynthesis and metabolic engineering of glucosinolates.

abstract：:Blood-borne angiotensin II (AngII) is known to mediate water-intake by its excitatory effect on neurons in the subfornical organ (SFO). Conversely, nitric oxide (NO) has exclusively inhibitory effects on rat SFO-neurons and on SFO-mediated water-intake. Extracellular and patch-clamp recordings from freshly dissociated...

journal_title：Amino acids

authors： Schmid HA

更新日期：1998-01-01 00:00:00

abstract：:Taurine depletion leads to impaired mitochondrial function, as characterized by reduced ATP production and elevated superoxide generation. These defects can fundamentally alter cardiomyocyte function and if left unchanged can result in cell death. To protect against these stresses, cardiomyocytes possess quality contr...

journal_title：Amino acids

authors： Jong CJ,Ito T,Schaffer SW

更新日期：2015-12-01 00:00:00

abstract：:Factor VIII, the plasma protein deficient or defective in individuals with hemophilia A, is a critical member of the blood coagulation cascade. Recent studies have identified the FVIII light chain region Glu1811-Lys1818 as being involved in FIXa binding and in the assembly of the FX-activating FIXaz-FVIIIa complex. Ba...

journal_title：Amino acids

authors： Patsialas K,Koutsas C,Makris P,Liakopoulou-Kyriakides M

更新日期：2010-07-01 00:00:00

abstract：:O-linked β-N-actylglucosamine (O-GlcNAc) is a carbohydrate post-translational modification on hydroxyl groups of serine and/or threonine residues of cytosolic and nuclear proteins. Analogous to phosphorylation, O-GlcNAcylation plays crucial regulatory roles in a variety of cellular processes. O-GlcNAc was termed a nut...

journal_title：Amino acids

authors： Ma Z,Vosseller K

更新日期：2013-10-01 00:00:00

abstract：:The glutamate/cystine antiporter system x(c)(-) transports cystine into cells in exchange for glutamate at a ratio of 1:1. It is composed of a specific light chain, xCT, and a heavy chain, 4F2, linked by a disulfide bridge. Intracellularly, cystine is reduced into cysteine, the rate-limiting precursor of glutathione (...

journal_title：Amino acids

authors： Lewerenz J,Maher P,Methner A

更新日期：2012-01-01 00:00:00

abstract：:The supplementation of creatine has shown a marked neuroprotective effect in mouse models of neurodegenerative diseases (Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis). This has been assigned to the known bioenergetic, anti-apoptotic, anti-excitotoxic and anti-oxidant properties of creatine....

journal_title：Amino acids

authors： Klopstock T,Elstner M,Bender A

更新日期：2011-05-01 00:00:00

abstract：:Agmatine, a metabolite generated by arginine decarboxylation, has been reported as neuromodulator and neuroactive substance. Several findings suggest that agmatine displays neuroprotective effects in several models of neurodegenerative disorders, such as Parkinson's disease (PD). It has been hypothesized that biogenic...

journal_title：Amino acids

authors： Ferlazzo N,Currò M,Giunta ML,Longo D,Rizzo V,Caccamo D,Ientile R

更新日期：2020-02-01 00:00:00

abstract：:The coupling between G protein-coupled receptors (GPCRs) and guanine nucleotide-binding proteins (G proteins) regulates various signal transductions from extracellular space into the cell. However, the coupling mechanism between GPCRs and G proteins is still unknown, and experimental determination of their coupling sp...

journal_title：Amino acids

authors： Li Z,Zhou X,Dai Z,Zou X

更新日期：2012-08-01 00:00:00

abstract：:A variety of alpha-amino acids are enantioresolved for the first time on naphthylethylcarbamate-beta-cyclodextrin bonded phases (i.e., SN- and RN-beta-CD) using the acetonitrile-based mobile phase after their pre-column derivatization with phenyl isothiocyanate in alkaline medium. The resolution is better obtained on ...

journal_title：Amino acids

authors： Chen S

更新日期：2004-06-01 00:00:00

abstract：:The human endothelin converting enzyme-1 (hECE-1) is a homodimer linked by a single disulfide bridge and has been identified as an important target for Alzheimer's disease. Structural analysis of hECE-1 dimer could lead to design specific and effective therapies against Alzheimer's disease. Hence, in the present study...

journal_title：Amino acids

authors： Sonawane KD,Barage SH

更新日期：2015-03-01 00:00:00

abstract：:The Disrupted-in-schizophrenia 1 (DISC1) gene is involved in vulnerability to neuropsychiatric disorders. Naples high-excitability (NHE) rat model neuropsychiatric problems characterized by an unbalanced mesocortical dopamine system. Here, we assessed behavioral and neurochemical effects of immunization against multim...

journal_title：Amino acids

authors： Ruocco LA,Treno C,Gironi Carnevale UA,Arra C,Boatto G,Pagano C,Tino A,Nieddu M,Michel M,Prikulis I,Carboni E,de Souza Silva MA,Huston JP,Sadile AG,Korth C

更新日期：2015-03-01 00:00:00

abstract：:Thrombin, the most potent physiological platelet agonist interacts with cells through a specific G protein-coupled receptor which has been cloned and sequenced. Synthetic thrombin receptor peptides (TRAPs) comprising the first 5 amino acids (SFLLR and SFLLR-NH2) of the new N-terminus tethered ligand of the thrombin re...

journal_title：Amino acids

authors： Alexopoulos K,Matsoukas J,Tselios T,Roumelioti P,Mavromoustakos T,Holada K

更新日期：1998-01-01 00:00:00

abstract：:Interplay between proteins, nucleic acids, carbohydrates and/or lipids is involved in almost every process in life on earth. As a consequence, a wide range of diseases results from abnormal interactions of such biomolecules. The main motivation of foldamer science is the development of scaffolds that are capable of ad...

journal_title：Amino acids

authors： Pilsl LK,Reiser O

更新日期：2011-08-01 00:00:00

abstract：:Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a...

journal_title：Amino acids

authors： Golubnitschaja O,Filep N,Yeghiazaryan K,Blom HJ,Hofmann-Apitius M,Kuhn W

更新日期：2018-04-01 00:00:00

abstract：:D-Amino acid oxidase cDNA was amplified by a polymerase chain reaction using RNA extracted from the mouse kidney. When digested withHindIII, the cDNAs of the BALB/c and ddY/DAO(-) mice were cleaved into two fragments whereas the cDNA of the ddY/DAO(+) mice was not. Sequencing revealed that nucleotide-471 of the cDNAs ...

journal_title：Amino acids

authors： Konno R,Sasaki M,Enami J,Niwa A

更新日期：1995-03-01 00:00:00

abstract：:Two experiments were conducted to evaluate the effects of dietary supplementation with Astragalus polysaccharide (APS) on growth performance, apparent ileal digestibilities (AID) of amino acids (AA), and their serum concentrations in early weaned piglets. In Exp. 1, 60 pigs were weaned at 21 days of age (BW 7.35 +/- 0...

journal_title：Amino acids

authors： Yin FG,Liu YL,Yin YL,Kong XF,Huang RL,Li TJ,Wu GY,Hou Y

更新日期：2009-07-01 00:00:00

abstract：:New bioinorganic complexes of the aspartic acid with the antimony or bismuth triiodide were synthesized by a direct solid-solid reaction at room temperature. The formula of the complex is MI(3)[OOCCH(2)CH(NH(2))CO](2.5) x 2.5H(2)O (M = Sb, Bi). The complex may be a dimer with bridge structure. The crystal structure of...

journal_title：Amino acids

authors： Jia RR,Wu CP,Wu S,Yang YX,Chen YR,Jia YQ

更新日期：2006-07-01 00:00:00

abstract：:eIF5A is highly conserved from archaea to mammals, essential for cell viability and the only protein known to contain the essential amino acid residue hypusine, generated by a unique posttranslational modification. eIF5A was originally identified as a translation initiation factor due to its ability to stimulate the f...

journal_title：Amino acids

authors： Dias CA,Gregio AP,Rossi D,Galvão FC,Watanabe TF,Park MH,Valentini SR,Zanelli CF

更新日期：2012-02-01 00:00:00

abstract：:Obesity, type 2 diabetes (T2DM) and cardiovascular disease (CVD) are the most common preventable causes of morbidity and mortality worldwide. They represent major public health threat to our society. Increasing prevalence of obesity and T2DM contributes to escalating morbidity and mortality from CVD and stroke. Carnos...

journal_title：Amino acids

authors： Baye E,Ukropcova B,Ukropec J,Hipkiss A,Aldini G,de Courten B

更新日期：2016-05-01 00:00:00

abstract：:Chemically defined amino acid diets have been developed for most laboratory and meat-producing animal species as well as for humans. In many cases, growth performance of animals fed these diets equals that obtained with standard intact-protein diets. The pattern of both essential and nonessential amino acids is critic...

journal_title：Amino acids

authors： Baker DH

更新日期：1992-02-01 00:00:00

abstract：:This study aimed to investigate the ability of curcumin to convert asparagine into acrylamide during heating at different temperatures. Binary and ternary model systems of asparagine-curcumin and asparagine-curcumin-fructose were used to determine the role of curcumin on acrylamide formation in competitive and uncompe...

journal_title：Amino acids

authors： Hamzalıoğlu A,Mogol BA,Lumaga RB,Fogliano V,Gökmen V

更新日期：2013-06-01 00:00:00

abstract：:Polyamines are essential for proliferation of endothelial cells (EC) and angiogenesis. This study was conducted to identify the metabolic source(s) of ornithine for polyamine synthesis in EC, using N(ω)-hydroxy-nor-L-arginine (Nor-NOHA, an inhibitor of arginase) and gabaculine (an inhibitor of ornithine aminotransfera...

journal_title：Amino acids

authors： Li H,Meininger CJ,Bazer FW,Wu G

更新日期：2016-10-01 00:00:00

abstract：:BE-3-3-3-3 (1,15-(ethylamino)4,8,12-triazapentadecane) is a bis(ethyl)polyamine analogue under investigation as a therapeutic agent for breast cancer. Since estradiol (E(2)) is a critical regulatory molecule in the growth of breast cancer, we examined the effect of BE-3-3-3-3 on estrogen receptor α (ERα) positive MCF-...

journal_title：Amino acids

authors： Nayvelt I,John S,Hsu HC,Yang P,Liu W,Das G,Hyvönen MT,Alhonen L,Keinänen TA,Shirahata A,Patel R,Thomas T,Thomas TJ

更新日期：2012-02-01 00:00:00

abstract：:This investigation sought to examine the contributions of exercise and nutrient replenishment on in vivo regulation of the insulin-like growth factor-I (IGF-I) axis components. Eight college-aged males completed three high-intensity interval training (HIIT) protocols followed by three post-exercise nutritional protoco...

journal_title：Amino acids

authors： Foster EB,Fisher G,Sartin JL,Elsasser TH,Wu G,Cowan W,Pascoe DD

更新日期：2012-04-01 00:00:00

abstract：:D-Asp-containing proteins have been implicated in many aging-related diseases. To clarify the role of D-Asp-containing proteins in such diseases, we developed a screening system for these proteins using a D-aspartyl endopeptidase that specifically cleaves the proteins at the C-terminus. The digested proteins were dete...

journal_title：Amino acids

authors： Sakai-Kato K,Kinouchi T,Fujii N,Imai K,Utsunomiya-Tate N

更新日期：2009-01-01 00:00:00

abstract：:The TES ether of the C6-hydroxy derivative of naturally occurring epi-jasmonic acid (epi-JA) was designed as epimerization-free equivalent of epi-JA. The TES ether was synthesized from (1R,4S)-4-hydroxycyclopent-2-enyl acetate in 13 steps. The acid part of the ether was activated with ClCO2Bui and subjected to condens...

journal_title：Amino acids

authors： Ogawa N,Kobayashi Y

更新日期：2012-05-01 00:00:00

abstract：:The role of pH-dependent ionic structures of L-amino acids in catalysis has been investigated for the two-component Mannich reactions between dimethyl malonate (DMM)/ethyl acetoacetate (EAA) and imines. As catalysts, L-amino acids performed well, even better than corresponding base catalysts and provided the β-amino c...

journal_title：Amino acids

authors： Rani D,Thakur L,Khera M,Goel N,Agarwal J

更新日期：2019-11-01 00:00:00

abstract：:The ventral pallidum is part of the corticoaccumbo-thalamocortical loop of the basal ganglia. In the past the function of this structure was discussed as a pure relay station in the process of limbic-motor integration. Some recent studies, however, underline that on the level of the ventral pallidum motor behavior can...

journal_title：Amino acids

authors： Kretschmer BD

更新日期：2000-01-01 00:00:00

abstract：:Schiff bases represent a class of molecules widely studied for their importance in organic and coordination chemistry. Despite the large amount of studies on the chemical and biological properties of the Schiff bases, the different experimental conditions prevent a useful comparison to search for a correlation structu...

journal_title：Amino acids

authors： Fattuoni C,Vascellari S,Pivetta T

更新日期：2020-03-01 00:00:00

abstract：:Lateral diffusion of membrane-integral receptors within the plane of the membrane has been postulated to be mechanistically important for signal transduction. Direct measurement of polypeptide hormone receptor lateral mobility using fluorescence photobleaching recovery techniques indicates that tyrosine kinase recepto...

journal_title：Amino acids

authors： Jans DA,Pavo I

更新日期：1995-06-01 00:00:00