Hyalinizing clear cell carcinoma of salivary glands: a study of extracellular matrix.

abstract：:The p53 pathway is commonly altered during oral and skin carcinogenesis. The lip is a transition tissue between skin and oral mucosa, which in response to UVB exposure also exhibits alterations in the expression of p53 and p53-related genes that could lead to malignant transformation. To assess if the p53-regulated pr...

journal_title：Oral oncology

authors： Martínez A,Brethauer U,Borlando J,Spencer ML,Rojas IG

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:The need to improve chemotherapeutic efficacy against head and neck squamous cell carcinomas (HNSCC) is well recognized. In this study, we investigated the potential of targeting the established tumor vasculature in combination with chemotherapy in head and neck cancer. METHODS:Experimental studies were carrie...

journal_title：Oral oncology

authors： Folaron M,Kalmuk J,Lockwood J,Frangou C,Vokes J,Turowski SG,Merzianu M,Rigual NR,Sullivan-Nasca M,Kuriakose MA,Hicks WL Jr,Singh AK,Seshadri M

更新日期：2013-09-01 00:00:00

abstract：:Nasopharyngeal carcinoma is well known to be a viral driven malignancy. Despite high loco-regional control rate with modern radiotherapy, distant metastasis remains as a major threat to the patients highlighting the importance of effective systemic therapy. Recent advances in the understanding of tumor biology, host c...

journal_title：Oral oncology

authors： Chiang AK,Mak NK,Ng WT

更新日期：2014-05-01 00:00:00

abstract：:To understand the role of 70 kDa heat shock protein (HSP70) in the pathogenesis of oral cancer, its expression was studied in human normal, premalignant and malignant oral mucosa. Cell surface expression of HSP70 was assessed in oral tissue specimens by flow cytometric analysis using a mouse monoclonal antibody agains...

journal_title：Oral oncology

authors： Kaur J,Das SN,Srivastava A,Ralhan R

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVES:Squamous cell carcinoma (SCC) of the tongue is one of the most common oral cancers, tongue dorsum being a site of low incidence of primary SCC. We report a rare case of SCC of the tongue dorsum in a 69-year-old man having a history of multiple cancers, including esophageal cancer, gastric cancer, and renal c...

journal_title：Oral oncology

authors： Yamasaki S,Tani R,Sakurai S,Toratani S,Okamoto T

更新日期：2020-10-01 00:00:00

abstract：:Traumatic eosinophilic granuloma of the oral mucosa, also known as eosinophilic ulcer, is considered to be a reactive lesion of unknown aetiology. It usually presents as a tongue ulcer and injury has been considered to play a role in its cause. We present a 72-year-old man who had suffered multiple episodes of recurre...

journal_title：Oral oncology

authors： Ficarra G,Prignano F,Romagnoli P

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVES:We evaluated the effects of three-dimensional virtual planning and the use of a plate-embedded surgical guide in mandibular reconstruction with microvascular fibula flaps. MATERIALS AND METHODS:We retrospectively reviewed 35 patients who underwent primary mandibular reconstruction with a free fibula flap. T...

journal_title：Oral oncology

authors： Bao T,He J,Yu C,Zhao W,Lin Y,Wang H,Liu J,Zhu H

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Surgical management of patients following zoledronic acid therapy is particularly difficult, since the dental extraction is the main cause of BRONJ. METHODS:A case-control study was conducted on 176 patients treated with intravenous (IV) bisphosphonates for oncologic pathologies who also underwent dental ex...

journal_title：Oral oncology

authors： Mozzati M,Arata V,Gallesio G

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Serologic analyses for anti-EBV antibodies used alone usually have low sensitivity for the diagnosis of nasopharyngeal carcinoma (NPC). We assumed that a combined determination of antibodies directed at EBV proteins expressed in both lytic and latent cycles could increase the sensitivity. MATERIALS AND METH...

journal_title：Oral oncology

authors： Ai P,Wang T,Zhang H,Wang Y,Song C,Zhang L,Li Z,Hu H

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:The incidence of nasopharyngeal carcinoma (NPC) is higher in Chinese than in Caucasian populations. Genetic, viral, and lifestyle factors may explain these ethnic differences in the incidence of NPC. In the present study, we examined the familial aggregation, heritability, and relative risks (RRs) of NPC usi...

journal_title：Oral oncology

authors： Huang SF,Hsiao JH,Young CK,Chien HT,Kuo CF,See LC,Luo SF,Huang LH,Liao CT,Chang TJ

更新日期：2017-10-01 00:00:00

abstract：:EGFR overexpression in salivary gland carcinomas provides the rational for the investigation of anti-EGFR treatments in recurrent and/or metastatic salivary gland cancers (RMSGCs). The activity of cetuximab in terms of clinical benefit rate (CBR) defined as the occurrence of objective response (CR or PR) or stable dis...

journal_title：Oral oncology

authors： Locati LD,Bossi P,Perrone F,Potepan P,Crippa F,Mariani L,Casieri P,Orsenigo M,Losa M,Bergamini C,Liberatoscioli C,Quattrone P,Calderone RG,Rinaldi G,Pilotti S,Licitra L

更新日期：2009-07-01 00:00:00

abstract：UNLABELLED:Despite significant advances in surgical procedures and treatment, long-term prognosis for patients with oral cancer remains poor, with survival rates among the lowest of major cancers. Better methods are desperately needed to identify potential malignancies early when treatments are more effective. OBJECTI...

journal_title：Oral oncology

authors： Abram TJ,Floriano PN,Christodoulides N,James R,Kerr AR,Thornhill MH,Redding SW,Vigneswaran N,Speight PM,Vick J,Murdoch C,Freeman C,Hegarty AM,D'Apice K,Phelan JA,Corby PM,Khouly I,Bouquot J,Demian NM,Weinstock YE,

更新日期：2016-09-01 00:00:00

abstract：:p53 is a transcription factor which regulates cell proliferation and apoptosis to prevent division of potentially malignant cells. In many tumours mutation of the p53 gene leads to stabilisation of this protein which can be detected by immunohistochemistry (IHC). However, there are many reports describing detection of...

journal_title：Oral oncology

authors： Partridge M,Kiguwa S,Emilion G,Pateromichelakis S,A'Hern R,Langdon JD

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. PATIENTS AND METHODS:This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available thro...

journal_title：Oral oncology

authors： Bonomi M,Bhateja P,Issa M,Klamer B,Pan X,Blakaj A,Karivedu V,Mousa L,Mitchell D,Gamez M,Kang S,Seim NB,Old M,Carrau R,Rocco J,Blakaj D

更新日期：2020-11-01 00:00:00

abstract：:We investigated the presence of neural cell adhesion molecule (N-CAM) in the adenoid cystic carcinoma cell line CAC2 using immunofluorescence microscopy. Additionally, we analysed the role of laminin and type IV collagen in N-CAM expression. We demonstrated that cultured adenoid cystic carcinoma cells express N-CAM. C...

journal_title：Oral oncology

authors： França CM,Jaeger MM,Jaeger RG,Araújo NS

更新日期：2000-03-01 00:00:00

abstract：:Betel quid, cigarettes and alcohol are well-recognized risk factors for oral cancer. However, the combined effect of the frequency and duration of these oral habits on the risk for developing oral pre-malignancies among betel quid users has not been fully addressed. In this study, an oral screening programme for men c...

journal_title：Oral oncology

authors： Yen AM,Chen SC,Chen TH

更新日期：2007-08-01 00:00:00

abstract：:We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngea...

journal_title：Oral oncology

authors： Nguyen NP,Ceizyk M,Vos P,Vinh-Hung V,Davis R,Desai A,Abraham D,Krafft SP,Jang S,Watchman CJ,Ewell L,Hamilton R,Smith-Raymond L

更新日期：2010-04-01 00:00:00

abstract：:Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several ...

journal_title：Oral oncology

authors： Schmitt NC,Kang H,Sharma A

更新日期：2017-11-01 00:00:00

abstract：:The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that ...

journal_title：Oral oncology

authors： Sun Q,Nawabi-Ghasimi F,Basile JR

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:The prognostic value of metabolic tumor volume (MTV) in locally advanced laryngeal or hypopharyngeal cancer is established in the setting of chemoradiotherapy, while it remains unknown in the setting of upfront total laryngectomy. MATERIALS AND METHODS:We retrospectively analyzed 88 patients receiving total...

journal_title：Oral oncology

authors： Fujii T,Miyabe J,Yoshii T,Suzuki M,Otozai S,Komukai S,Kishikawa T,Takemoto N,Fukusumi T,Tatsumi M,Hatazawa J,Inohara H

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Feeding tubes are placed unnecessarily in a proportion of head and neck cancer (HNC) patients treated with chemoradiotherapy (CRT) when prophylactic tube placement protocols are used. This may have a negative impact on the risk of long-term dysphagia. Reactive tube placement protocols, on the other hand, mig...

journal_title：Oral oncology

authors： Karsten RT,Stuiver MM,van der Molen L,Navran A,de Boer JP,Hilgers FJM,Klop WMC,Smeele LE

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:The long-term results of RTOG 91-11 suggested increased deaths not attributed to larynx cancer after concomitant chemoradiotherapy (CRT) despite no apparent increase in late effects. Because the timing of events was not reported by RTOG 91-11, one possibility is that severe late dysphagia (SLD) develops beyond ...

journal_title：Oral oncology

authors： Ward MC,Adelstein DJ,Bhateja P,Nwizu TI,Scharpf J,Houston N,Lamarre ED,Lorenz R,Burkey BB,Greskovich JF,Koyfman SA

更新日期：2016-06-01 00:00:00

abstract：:A new photosensitizing agent 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has been demonstrated as a useful method for treatment of superficial neoplastic lesions. The aim of this study was to determine the effects of topically and systemically ALA-based PDT in neoplastic lesions of the oral cavity. Pr...

journal_title：Oral oncology

authors： Ma G,Ikeda H,Inokuchi T,Sano K

更新日期：1999-01-01 00:00:00

abstract：:This study was aimed at estimating the pooled global leukoplakia prevalence using both well-designed studies, which were too few to be representative of the world situation, and less valuable studies. The inverse variance weighting and the random effect methods were used. The latter is based on the principle that if p...

journal_title：Oral oncology

authors： Petti S

更新日期：2003-12-01 00:00:00

abstract：:Oral mucositis (OM) is a devasting toxicity associated with cytotoxic cancer therapy. Antrum mucosal protein (AMP)-18 and a synthetic peptide surrogate, exhibit cell protective and mitogenic properties in in vitro and in vivo models of gastrointestinal epithelial cell injury. The mucosal barrier-protective effects may...

journal_title：Oral oncology

authors： Chen P,Lingen M,Sonis ST,Walsh-Reitz MM,Toback FG

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVES:The advantages of the circulating cell-free DNA (cfDNA) methodology are quick results and the possibility of repeated analysis. The main aim of our study was to establish the relationship of the total cfDNA with patients' clinical characteristics and circulating HPV DNA detection in the blood of patients wit...

journal_title：Oral oncology

authors： Mazurek AM,Rutkowski T,Fiszer-Kierzkowska A,Małusecka E,Składowski K

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:The hepatocyte growth factor receptor (Met) is frequently overexpressed in Head and Neck Squamous Cell Carcinoma (HNSCC), correlating positively with high-grade tumors and shortened patient survival. As such, Met may represent an important therapeutic target. The purpose of this study was to explore the role...

journal_title：Oral oncology

authors： Tao X,Hill KS,Gaziova I,Sastry SK,Qui S,Szaniszlo P,Fennewald S,Resto VA,Elferink LA

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Elective neck dissection (END) for salvage laryngectomy remains controversial due to variability in reported occult nodal metastasis rates and postoperative complications. We performed a meta-analysis to examine the role of END for treatment of the clinically N0 (cN0) neck in the salvage setting. METHODS:A P...

journal_title：Oral oncology

authors： Lin C,Puram SV,Bulbul MG,Sethi RK,Rocco JW,Old MO,Kang SY

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:The present study aimed to clarify the role of Moesin in oral squamous cell carcinoma (OSCC) progression, especially in regulation of cell motility. MATERIALS AND METHODS:Immunohistochemistry and western blotting were used to investigate the expression of Moesin, E-cadherin, p120-catenin and MT1-MMP in norma...

journal_title：Oral oncology

authors： Li YY,Zhou CX,Gao Y

更新日期：2015-10-01 00:00:00

abstract：UNLABELLED:Squamous cell carcinoma of the tongue (TSCC) has one of the poorest prognoses of head and neck cancers. This study aims to improve early detection of the disease by identifying salivary biomarkers that can identify a spectrum of patients progressing from high-risk to TSCC. We also examine the mortality of ex...

journal_title：Oral oncology

authors： Korostoff A,Reder L,Masood R,Sinha UK

更新日期：2011-04-01 00:00:00