Corneal endothelial damage after trabeculectomy with mitomycin C in two patients with glaucoma with cornea guttata.

Abstract:

PURPOSE:To report two patients with glaucoma who exhibited severe damage to the corneal endothelium after a trabeculectomy with mitomycin C (MMC). METHODS:This study includes clinical histories and specular microscopic pictures of the cases. RESULTS:Both patients were middle-aged women, underwent trabeculectomy with MMC, had moderate to severe cornea guttata preoperatively, and developed a shallow to flat anterior chamber, classified as grade 2 according to Spaeth early in the postoperative period. Stromal opacity caused by corneal edema associated with severe Descemet's membrane folds appeared within 2 to 5 days in both cases. The density of the corneal endothelium was decreased on specular microscopic examination. The severe corneal endothelial damage seen after the trabeculectomy with MMC was likely owing to a combination of the preexisting cornea guttata, the flat anterior chamber, and possibly the administration of MMC. CONCLUSION:Severe endothelial damage after trabeculectomy with MMC may occur in patients with glaucoma and associated cornea guttata. The use of tight sutures on the scleral flap or a modified operative method, nonpenetrating trabeculectomy, may be effective in preventing a shallow to flat anterior chamber postoperatively.

journal_name

Cornea

journal_title

Cornea

authors

Fukuchi T,Hayakawa Y,Hara H,Abe H

doi

10.1097/00003226-200204000-00012

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

300-4

issue

3

eissn

0277-3740

issn

1536-4798

journal_volume

21

pub_type

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