Cellular senescence as a stress response.

Abstract:

PURPOSE:This review discusses cellular senescence, the state in which normal cells do not respond to growth stimuli, and shows characteristic alterations in their cytologic and biochemical properties and their gene expression profiles. METHODS AND RESULTS:Cellular senescence is elicited by various stresses. It was recently shown that the stress-induced mitogen-activated protein kinase p38 has a pivotal role in inducing cellular senescence. This finding provided biochemical evidence to support the notion that cellular senescence is a kind of stress response. CONCLUSION:Stress responses are typically found in cells and organisms surviving unfavorable environmental conditions. It can be argued that cellular senescence is an adaptive process that maintains the cell's viability by reducing the energy consumed for reproduction (ie, cell division) and differentiation-related activities.

journal_name

Cornea

journal_title

Cornea

authors

Ishikawa F

doi

10.1097/01.ico.0000247206.47897.92

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

S3-6

issue

10 Suppl 1

eissn

0277-3740

issn

1536-4798

pii

00003226-200612001-00002

journal_volume

25

pub_type

杂志文章,评审

相关文献

CORNEA文献大全
  • Subconjunctival bevacizumab for corneal neovascularization.

    abstract:PURPOSE:To describe whether subconjunctival bevacizumab decreases corneal neovascularization in patients with ocular surface inflammatory diseases. METHODS:The study is a retrospective case series that includes 8 eyes of 7 patients with corneal neovascularization. Patients received 1-3 injections of 2.5 mg subconjunct...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31817786ad

    authors: Doctor PP,Bhat PV,Foster CS

    更新日期:2008-10-01 00:00:00

  • Association Between Season, Temperature and Causative Organism in Microbial Keratitis in the UK.

    abstract:PURPOSE:Microbial keratitis (MK) is a major cause of corneal blindness worldwide. Variations in season and temperature can affect MK incidence due to specific causative organisms; however, few studies have examined these factors in the UK. METHODS:Retrospective review of all corneal scrapes from patients with MK prese...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ICO.0000000000001748

    authors: Walkden A,Fullwood C,Tan SZ,Au L,Armstrong M,Brahma AK,Chidambaram JD,Carley F

    更新日期:2018-12-01 00:00:00

  • Sutured clear corneal incision: wound apposition and permeability to bacterial-sized particles.

    abstract:PURPOSE:To determine the effects of single radial or horizontal suture placement in 2-step clear corneal incision (CCI) wound apposition and permeability to particles of India ink. METHODS:Five fresh human globes were included. Two 25-gauge needles connected to a saline solution bag and to a digital manometer were ins...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31824d0d45

    authors: May WN,Castro-Combs J,Kashiwabuchi RT,Tattiyakul W,Qureshi-Said S,Hirai F,Behrens A

    更新日期:2013-03-01 00:00:00

  • Human anterior lens capsule as carrier matrix for cultivated human corneal endothelial cells.

    abstract:PURPOSE:To evaluate the potential of human anterior lens capsule (HALC) as a carrier matrix for cultivating and transplanting human corneal endothelial cells (HCECs). METHODS:HALCs obtained from 12 patients during cataract surgery were exposed to enzyme digestion to dissolve the lens epithelium and were plated with th...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31818c2c36

    authors: Yoeruek E,Saygili O,Spitzer MS,Tatar O,Bartz-Schmidt KU,Szurman P

    更新日期:2009-05-01 00:00:00

  • New Method for Removing Thermosensitive Acrylic Punctal Plugs From Lacrimal Puncta.

    abstract:PURPOSE:This study explored a new method for removing thermosensitive acrylic punctal plugs from lacrimal puncta. METHODS:A total of 14 dry eye patients (14 eyes), who required the removal of thermosensitive acrylic punctal plugs from the lacrimal puncta because of serious complications, were recruited. Among the 14 p...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000633

    authors: Zhang M,Zhang X

    更新日期:2015-12-01 00:00:00

  • On the morphology of cells of posterior cornea in the iridocorneal endothelial syndrome.

    abstract::The iridocorneal endothelial (ICE) syndrome is potentially a blinding condition as a result of glaucoma and/or corneal decompensation. The basic pathology seems to be in the corneal endothelium, which many studies confirm takes on a characteristic slit lamp appearance of hammered silver and image reversal with the spe...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199105000-00009

    authors: Sherrard ES,Frangoulis MA,Muir MG

    更新日期:1991-05-01 00:00:00

  • Corneal transplant rejection rate and severity after endothelial keratoplasty.

    abstract:PURPOSE:To examine the corneal transplant rejection rate and the rate of graft failure subsequent to rejection in the first 2 years after endothelial keratoplasty (EK) and to compare this to background data for similar cases of penetrating keratoplasty (PK). METHODS:Anonymized data from consecutive cases of EK [deep l...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ICO.0b013e31812f66e5

    authors: Allan BD,Terry MA,Price FW Jr,Price MO,Griffin NB,Claesson M

    更新日期:2007-10-01 00:00:00

  • Incidence of HIV antibody-positive eye/cornea donors in hospital versus medical examiner cases.

    abstract::We retrospectively examined Michigan Eye-Bank and Transplantation Center data on all eye/cornea donors in Michigan and Illinois for whom human immunodeficiency virus (HIV) antibody screening results were available. This was done to compare the HIV-antibody positive serology rate in hospital versus medical examiner don...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Danneffel MB,Sugar A

    更新日期:1990-07-01 00:00:00

  • Tear film volume and protein analysis in full-term newborn infants.

    abstract:PURPOSE:To investigate infant tear film secretion and protein profile, and to compare major tear proteins, such as immunoglobulin A, lactoferrin, and lysozyme, with those of adult controls. METHODS:Tears were collected, with a cellulose rod, from 40 healthy infants (19 female infants and 21 male infants, gestational d...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181f22cd9

    authors: Esmaeelpour M,Watts PO,Boulton ME,Cai J,Murphy PJ

    更新日期:2011-04-01 00:00:00

  • Corneal Stiffness and Its Relationship With Other Corneal Biomechanical and Nonbiomechanical Parameters in Myopic Eyes of Chinese Patients.

    abstract:PURPOSE:To investigate corneal stiffness and analyze its possible influence on other corneal biomechanical and nonbiomechanical parameters in myopic eyes of Chinese patients. METHODS:A total of 387 healthy (right) myopic eyes were included in this study. Corneal visualization Scheimpflug technology was used to measure...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001605

    authors: Zhang Y,Wang Y,Li L,Dou R,Wu W,Wu D,Jhanji V

    更新日期:2018-07-01 00:00:00

  • Corneal thickness is reduced in dry eye.

    abstract:PURPOSE:To evaluate and compare corneal thickness in normal and dry eyes. METHODS:The Orbscan corneal topography system was used to measure the corneal thickness at nine locations in the central and peripheral (superior, superonasal, nasal, inferonasal, inferior, inferotemporal, temporal, superotemporal) cornea in 38 ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199907000-00002

    authors: Liu Z,Pflugfelder SC

    更新日期:1999-07-01 00:00:00

  • Ocular morbidity associated with airbag deployment: a report of seven cases and a review of the literature.

    abstract:PURPOSE:To review ocular injuries secondary to airbag deployment that were seen in our institution and were reported in the literature. METHODS:Patients examined at our institution between 1997 and 2000 were evaluated for ocular injuries caused by airbags. A review of the medical literature using Medline was performed...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/00003226-200103000-00009

    authors: Ball DC,Bouchard CS

    更新日期:2001-03-01 00:00:00

  • Detection of herpes simplex virus type 1 in failed descemet stripping automated endothelial keratoplasty grafts.

    abstract:PURPOSE:To determine the prevalence of herpes simplex virus type 1 (HSV-1) DNA in failed Descemet membrane stripping automated endothelial keratoplasty (DSAEK) grafts. METHODS:A retrospective interventional case series of patients with DSAEK graft failure treated at the New York Eye and Ear Infirmary between January 2...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31829b6d0c

    authors: Yin D,Huang A,Warrow D,Ritterband DC,Seedor JA,McCormick SA,Milman T

    更新日期:2013-09-01 00:00:00

  • Transplantation of cultured human corneal endothelial cells.

    abstract:PURPOSE:To investigate the feasibility of corneal reconstruction utilizing cultured human corneal endothelial cells (HCECs). METHODS:We cultivated HCECs using culture dishes pre-coated with bovine corneal endothelial extracellular matrix. The effect of donor age on HCECs was investigated. We reconstructed corneas usin...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200310001-00010

    authors: Amano S

    更新日期:2003-10-01 00:00:00

  • Corneal Transplantation in New Zealand 2000 to 2009.

    abstract:PURPOSE:To quantify all minor/major adverse events in a large cohort of consecutive corneal transplants, particularly in respect to penetrating keratoplasty (PKP). METHODS:All corneal transplants in the Auckland region over a 10-year period (2000-2009) were identified through the New Zealand National Eye Bank. Relevan...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001481

    authors: Crawford AZ,Krishnan T,Ormonde SE,Patel DV,McGhee CN

    更新日期:2018-03-01 00:00:00

  • Potentiation by cyclic AMP of the stimulatory effect of epidermal growth factor on corneal epithelial migration.

    abstract:PURPOSE:To provide insight into the mechanism by which epidermal growth factor (EGF) stimulates corneal epithelial migration, we investigated the possible interaction between EGF and cyclic AMP (cAMP) signaling pathways during epithelial migration with an organ culture system for the rabbit cornea. METHODS:Rabbit corn...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200305000-00014

    authors: Nakamura M,Nishida T

    更新日期:2003-05-01 00:00:00

  • Dry Eye Assessment in Patients With Vitiligo.

    abstract:PURPOSE:To evaluate tear osmolarity and tear film parameters in patients with vitiligo. METHODS:A total of 25 eyes of 25 patients with vitiligo with periocular involvement (group 1), 30 eyes of 30 patients with vitiligo without periocular involvement (group 2), and 20 eyes of 20 controls (group 3) were evaluated using...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001469

    authors: Erdur SK,Aydin R,Balevi A,Ozsutcu M,Kocabora MS

    更新日期:2018-04-01 00:00:00

  • Correlation between tear film osmolarity, dry eye disease, and rheumatoid arthritis.

    abstract:PURPOSE:The aim of this study was to evaluate the reliability of tear film osmolarity as a diagnostic tool for detecting dry eye disease (DED) in patients with rheumatoid arthritis (RA). The second aim was to determine whether there is a relationship between tear film osmolarity, a commonly used RA score, and diagnosti...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000257

    authors: Schargus M,Wolf F,Tony HP,Meyer-Ter-Vehn T,Geerling G

    更新日期:2014-12-01 00:00:00

  • Laser-assisted in situ keratomileusis complications in diabetes mellitus.

    abstract:PURPOSE:To report the incidence of complications and the refractive results in patients with diabetes mellitus treated with laser-assisted in situ keratomileusis (LASIK). METHODS:A retrospective review of the charts, focusing on 6-month postoperative data, was performed on 30 eyes from patients with diabetes and 150 a...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200204000-00002

    authors: Fraunfelder FW,Rich LF

    更新日期:2002-04-01 00:00:00

  • Outcomes of repeat endothelial keratoplasty in patients with failed deep lamellar endothelial keratoplasty.

    abstract:PURPOSE:To report the outcomes of repeat endothelial keratoplasty (EK) in patients with previous failed deep lamellar endothelial keratoplasty (DLEK). METHODS:This retrospective interventional case series involved the review of clinical records of patients with failed DLEK surgery who underwent repeat EK surgery. RES...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31821522b4

    authors: Kim P,Brodbaker E,Lichtinger A,Yeung SN,Bahar I,Iovieno A,Amiran MD,Rootman DS

    更新日期:2011-11-01 00:00:00

  • Evaluation of endothelial mucin layer thickness after phacoemulsification with next generation ophthalmic irrigating solution.

    abstract:PURPOSE:To evaluate human corneal endothelial mucin layer thickness and ultrastructure after phacoemulsification and irrigation-aspiration with either next generation ophthalmic irrigating solution (NGOIS) or BSS PLUS. METHODS:Paired human corneas were mounted in an artificial anterior chamber, exposed to 3 minutes of...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31817313cb

    authors: Ghate DA,Holley G,Dollinger H,Bullock JP,Markwardt K,Edelhauser HF

    更新日期:2008-10-01 00:00:00

  • Refractive Surgery: Malpractice Litigation Outcomes.

    abstract:PURPOSE:To review data on malpractice claims related to refractive surgery to identify common allegations and injuries and financial outcomes. METHODS:The WestlawNext database was reviewed for all malpractice lawsuits/settlements related to refractive eye surgery. Data evaluated included patient demographics, type of ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001289

    authors: Custer BL,Ballard SR,Carroll RB,Barnes SD,Justin GA

    更新日期:2017-10-01 00:00:00

  • Artificial human corneas: scaffolds for transplantation and host regeneration.

    abstract:PURPOSE:To review the development of artificial corneas (prostheses and tissue equivalents) for transplantation, and to provide recent updates on our tissue-engineered replacement corneas. METHODS:Modified natural polymers and synthetic polymers were screened for their potential to replace damaged portions of the huma...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/01.ico.0000263120.68768.f8

    authors: Griffith M,Hakim M,Shimmura S,Watsky MA,Li F,Carlsson D,Doillon CJ,Nakamura M,Suuronen E,Shinozaki N,Nakata K,Sheardown H

    更新日期:2002-10-01 00:00:00

  • Recurrence Rate and Graft Stability With Fibrin Glue Compared With Suture and Autologous Blood Coagulum for Conjunctival Autograft Adherence in Pterygium Surgery: A Meta-Analysis.

    abstract:PURPOSE:To minimize recurrence and improve graft stability after pterygium surgery, conjunctival autograft adherence is done using fibrin glue (FG) or autologous blood coagulum (ABC). But there are studies that have reported conflicting or inconclusive results. This meta-analysis was conducted to evaluate the postopera...

    journal_title:Cornea

    pub_type: 杂志文章,meta分析

    doi:10.1097/ICO.0000000000001270

    authors: Maiti R,Mukherjee S,Hota D

    更新日期:2017-10-01 00:00:00

  • A combined approach of amniotic membrane and oral mucosa transplantation for fornix reconstruction in severe symblepharon.

    abstract:PURPOSE:To evaluate the results of a combined approach of cicatrix lysis, intraoperative mitomycin C (MMC) application, oral mucosal transplantation (OMT), and amniotic membrane transplantation (AMT) for surgery of severe symblepharon. METHODS:This prospective study included 32 eyes with severe symblepharon in which a...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318247983d

    authors: Kheirkhah A,Ghaffari R,Kaghazkanani R,Hashemi H,Behrouz MJ,Raju VK

    更新日期:2013-02-01 00:00:00

  • Corneal trephination with the femtosecond laser.

    abstract:PURPOSE:To evaluate the feasibility and cut quality of corneal trephination in human donor corneal tissue with the femtosecond laser. METHODS:Twelve human corneoscleral discs were inserted in an artificial anterior chamber. After corneal thickness measurement and tonometry, the cornea was mounted on a femtosecond lase...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000228784.46463.e9

    authors: Meltendorf C,Schroeter J,Bug R,Kohnen T,Deller T

    更新日期:2006-10-01 00:00:00

  • Gross factors in treatment of nonhealing corneal ulcers and recurrent erosions.

    abstract::Epidermal growth factor (EGF) is known to promote corneal epithelial wound healing in experimental scrape and keratectomy models. We studied its efficacy in treating alkali-burned epithelial ulceration. EGF induced hyperplasia and cell proliferation to resurface the denuded and denatured corneal stroma, but it did not...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Singh G,Foster CS

    更新日期:1989-01-01 00:00:00

  • Factors involved in the occurrence of bleeding complications after enucleation for cornea donation.

    abstract:PURPOSE:To identify risk factors for the occurrence of bleeding complications after enucleation for cornea donation, in order to develop preventive activities to reduce the occurrence of bleeding complications and especially the development of ocular hematomas. METHODS:From all Dutch cornea donors deceased in the year...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181a186fc

    authors: van Wijk MJ,Nijenhuis MV,Dorrepaal CA,Bokhorst AG

    更新日期:2009-10-01 00:00:00

  • Antimicrobial activity of antibiotic-treated amniotic membrane: An in vitro study.

    abstract:PURPOSE:To investigate if amniotic membrane incubated with antibiotics could inhibit bacterial growth in vitro. METHODS:Amniotic membrane fragments were incubated with the antibiotics (netilmicin) solution; the washed and drained fragments were either tested after treatment or further incubated in antibiotic-free medi...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000214207.06952.23

    authors: Mencucci R,Menchini U,Dei R

    更新日期:2006-05-01 00:00:00

  • Limbal stem cell transplantation for the treatment of subepithelial amyloidosis of the cornea (gelatinous drop-like dystrophy).

    abstract:PURPOSE:Subepithelial amyloidosis of the cornea, or gelatinous drop-like corneal dystrophy (GDD), is a severe form of corneal stromal amyloidosis predominantly found in the Japanese population. GDD causes severe visual disturbances with irritating symptoms, and keratoplasty is inevitably complicated by early recurrence...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200203000-00010

    authors: Shimazaki J,Shimmura S,Tsubota K

    更新日期:2002-03-01 00:00:00