Keratitis resulting from Thielavia subthermophila Mouchacca.

Abstract:

PURPOSE:The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp. METHODS:We conducted a retrospective chart review. RESULTS:A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined margins. Cultures of corneal scrapings and biopsy sequence analysis of the ribosomal internal transcribed spacer region isolated Thielavia subthermophila Mouchacca. Clinically, the organism appeared to respond to topical amphotericin B and oral voriconazole. Best-corrected visual acuity at last follow-up visit counted 0.5. CONCLUSIONS:A rare case of Thielavia sp. keratitis was successfully treated with topical amphotericin B and oral voriconazole. Newly developed molecular diagnostic tools contribute to the recognition of a widening spectrum of emerging fungal pathogens capable of causing serious ocular infections.

journal_name

Cornea

journal_title

Cornea

authors

Theoulakis P,Goldblum D,Zimmerli S,Muehlethaler K,Frueh BE

doi

10.1097/ICO.0b013e31819717f4

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1067-9

issue

9

eissn

0277-3740

issn

1536-4798

journal_volume

28

pub_type

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