Keratitis resulting from Thielavia subthermophila Mouchacca.


PURPOSE:The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp. METHODS:We conducted a retrospective chart review. RESULTS:A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined margins. Cultures of corneal scrapings and biopsy sequence analysis of the ribosomal internal transcribed spacer region isolated Thielavia subthermophila Mouchacca. Clinically, the organism appeared to respond to topical amphotericin B and oral voriconazole. Best-corrected visual acuity at last follow-up visit counted 0.5. CONCLUSIONS:A rare case of Thielavia sp. keratitis was successfully treated with topical amphotericin B and oral voriconazole. Newly developed molecular diagnostic tools contribute to the recognition of a widening spectrum of emerging fungal pathogens capable of causing serious ocular infections.






Theoulakis P,Goldblum D,Zimmerli S,Muehlethaler K,Frueh BE




Has Abstract


2009-10-01 00:00:00














  • Terrien's marginal degeneration with corneal cyst.

    abstract::Spontaneous ruptures in Descemet's membrane in Terrien's degeneration can result in a corneal intralamellar pocket of fluid. We present a case and discuss its management. ...


    pub_type: 杂志文章


    authors: Romanchuk KG,Hamilton WK,Braig RF

    更新日期:1990-01-01 00:00:00

  • Surgical Management of Limbal Dermoids Using Anterior Corneal Buttons From Descemet Stripping Automated Endothelial Keratoplasty Donor Tissue as Patch Grafts.

    abstract:PURPOSE:To assess the surgical and clinical outcomes of anterior lamellar keratoplasty using anterior corneal buttons from Descemet stripping automated endothelial keratoplasty (DSAEK) donor tissue. METHODS:Retrospective data from 8 patients with unilateral limbal dermoids, treated between February 2011 and January 20...


    pub_type: 杂志文章


    authors: Wu KI,Chu HS,Pai AS,Hou YC,Lin SY,Chen WL,Hu FR

    更新日期:2017-01-01 00:00:00

  • Peripheral ulcerative keratitis after Salmonella gastroenteritis.

    abstract:PURPOSE:To describe a case of bilateral peripheral ulcerative keratitis after Salmonella gastroenteritis. METHODS:Case report with description of treatment and outcome. RESULTS:The peripheral ulcerative keratitis gradually resolved in both eyes after appropriate systemic antibiotic therapy and local ocular care. CON...


    pub_type: 杂志文章


    authors: Yang J,Baltatzis S,Foster CS

    更新日期:1998-11-01 00:00:00

  • Progressive replacement of oral mucosa by conjunctiva in osteo-odonto-keratoprosthesis: preliminary observations.

    abstract:PURPOSE:In a Strampelli osteo-odonto-keratoprosthesis, a patch of oral mucosa is frequently used to cover the ocular surface after implantation of an osteodental lamina into the eye. In many cases, gross modifications in the eye covering become apparent a few years later. The aim of this study was to investigate the hi...


    pub_type: 杂志文章


    authors: Pecorella I,Maurizio T,Antonio C,Giancarlo F

    更新日期:2006-02-01 00:00:00

  • Pachymetry-guided intrastromal air injection ("pachy-bubble") for deep anterior lamellar keratoplasty.

    abstract::To evaluate an innovative technique for intrastromal air injection to achieve deep anterior lamellar keratoplasty (DALK) with bare Descemet membrane (DM). Thirty-four eyes with anterior corneal pathology, including 27 with keratoconus, underwent DALK. After 400 μm trephination with a suction trephine, ultrasound pachy...


    pub_type: 杂志文章


    authors: Ghanem RC,Ghanem MA

    更新日期:2012-09-01 00:00:00

  • Multimodal Assessment of Corneal Thinning Using Optical Coherence Tomography, Scheimpflug Imaging, Pachymetry, and Slit-Lamp Examination.

    abstract:PURPOSE:To assess the relationship between corneal thinning measured by clinician-graded slit-lamp examination compared with ultrasound pachymetry (USP), anterior segment optical coherence tomography (AS-OCT), and the Pentacam. METHODS:Patients with corneal thinning underwent USP, AS-OCT, Pentacam measurements and sta...


    pub_type: 杂志文章


    authors: Oatts JT,Keenan JD,Mannis T,Lietman TM,Rose-Nussbaumer J

    更新日期:2017-04-01 00:00:00

  • Conjunctival impression cytology in patients wearing contact lenses.

    abstract:PURPOSE:Evaluation of contact lens-induced cytologic changes on the conjunctival surface. METHODS:Fifty eyes of 25 patients wearing soft or rigid gas-permeable contact lenses, and 50 healthy eyes of 25 control subjects were examined with conjunctival impression cytology. Of the patients wearing contact lenses, 40% did...


    pub_type: 杂志文章


    authors: Adar S,Kanpolat A,Sürücü S,Ucakhan OO

    更新日期:1997-05-01 00:00:00

  • Keratinizing corneal intraepithelial neoplasia.

    abstract::Corneal intraepithelial neoplasia (CIN) is the term applied by some authors to the spectrum of disease ranging from mild dysplasia to carcinoma in situ. Such lesions usually are associated with dysplastic or neoplastic processes at the limbus or adjacent conjunctiva; isolated corneal dysplasia is rare. Clinically, CIN...


    pub_type: 杂志文章


    authors: Brown HH,Glasgow BJ,Holland GN,Foos RY

    更新日期:1989-09-01 00:00:00

  • Gross factors in treatment of nonhealing corneal ulcers and recurrent erosions.

    abstract::Epidermal growth factor (EGF) is known to promote corneal epithelial wound healing in experimental scrape and keratectomy models. We studied its efficacy in treating alkali-burned epithelial ulceration. EGF induced hyperplasia and cell proliferation to resurface the denuded and denatured corneal stroma, but it did not...


    pub_type: 杂志文章


    authors: Singh G,Foster CS

    更新日期:1989-01-01 00:00:00

  • Amniotic membrane transplantation after the primary surgical management of band keratopathy.

    abstract:PURPOSE:To determine the safety and efficacy of amniotic membrane transplantation to restore and maintain a stable corneal epithelium and reduce ocular surface pain after surgical removal of band keratopathy arising from ocular causes. METHODS:Fifteen patients (16 eyes) from two centers with band keratopathy secondary...


    pub_type: 杂志文章,多中心研究


    authors: Anderson DF,Prabhasawat P,Alfonso E,Tseng SC

    更新日期:2001-05-01 00:00:00

  • Thickness and Curvature Changes of Human Corneal Grafts in Dextran-Containing Organ Culture Medium Before Keratoplasty.

    abstract:PURPOSE:To determine the changes of corneal thickness and curvature of human corneal grafts in organ culture medium II, containing dextran T500 6%, before keratoplasty. METHODS:We examined the tomography of 24 corneas from our eye bank transferred from medium I into medium II. Images were repeated hourly during 24 hou...


    pub_type: 杂志文章


    authors: Hamon L,Daas L,Mäurer S,Weinstein I,Quintin A,Schulz K,Langenbucher A,Seitz B

    更新日期:2020-12-04 00:00:00

  • Nineteen years of penetrating keratoplasty in the Hotel-Dieu Hospital in Paris.

    abstract:PURPOSE:To identify changing trends in penetrating keratoplasties (PKs) performed at the Hotel-Dieu Hospital in Paris between January 1980 and December 1999 and to explain the reasons for the changes. METHODS:We retrospectively reviewed 3,736 of the 3,836 PKs performed between January 1, 1980, and December 31, 1999, a...


    pub_type: 杂志文章


    authors: Legeais JM,Parc C,d'Hermies F,Pouliquen Y,Renard G

    更新日期:2001-08-01 00:00:00

  • Elevated tear IgG and conjunctival plasma cell infiltrate in a graft versus host disease patient.

    abstract::Two patients developed graft versus host disease (GvHD) following allogeneic bone marrow transplantation for leukemia. One patient developed acute GvHD 12 days after transplantation, and the second developed chronic GvHD 100 days after transplantation. Tear analysis and conjunctival impression cytology were performed....


    pub_type: 杂志文章


    authors: Heitman KF,Lam KW,Maskin SL,Yee RW,Lawton AW

    更新日期:1988-01-01 00:00:00

  • Incidence and clinical characteristics of enterococcus keratitis.

    abstract:PURPOSE:To study the incidence, clinically relevant factors, and antibiotic sensitivity profile of cases of enterococcal keratitis presenting at the New York Eye and Ear Infirmary between January 1, 1996, and December 31, 2005. METHODS:The records of all corneal cultures submitted to the Microbiology Laboratory of the...


    pub_type: 杂志文章


    authors: Rau G,Seedor JA,Shah MK,Ritterband DC,Koplin RS

    更新日期:2008-09-01 00:00:00

  • Recurrent Conjunctival Myofibrosarcoma Managed With Triple Application of Episcleral Brachytherapy.

    abstract:PURPOSE:To report a case of recurrent conjunctival myofibrosarcoma treated with wide surgical excision, cryotherapy, and triple sequential applications of episcleral brachytherapy. METHODS:A single case of recurrent conjunctival myofibrosarcoma. RESULTS:A 54-year-old man with a history of a renal transplant presented...


    pub_type: 杂志文章


    authors: Platt SM,Schoenfield L,Basti S,Bryar PJ,Goldblum JR,Singh A,Singh AD

    更新日期:2017-05-01 00:00:00

  • Nontraumatic corneal perforation.

    abstract:PURPOSE:To study the predisposing conditions, treatments, and visual outcomes of nontraumatic corneal perforations. METHODS:A retrospective chart review was conducted of all nontraumatic corneal perforations seen between January 1992 and December 1998, with > or = 3 months of follow-up, at the Cornea Service Wills Eye...


    pub_type: 杂志文章


    authors: Lekskul M,Fracht HU,Cohen EJ,Rapuano CJ,Laibson PR

    更新日期:2000-05-01 00:00:00

  • Recurrent keratoconus.

    abstract::Keratoconus is a progressive, noninflammatory, nonvascular axial corneal ectasia, with unclear etiology and pathogenesis. It has a prevalence of 50-230 per 100,000 and is a bilateral disorder in up to 90% of cases. The onset of keratoconus is usually at puberty and progresses over 10-20 years producing an irregular my...


    pub_type: 杂志文章


    authors: Bechrakis N,Blom ML,Stark WJ,Green WR

    更新日期:1994-01-01 00:00:00

  • Ofloxacin in human serum, urine, and tear film after topical application.

    abstract::We evaluated the systemic absorption of ofloxacin eyedrops in humans and their availability in the tear film. Serum, urine, and tear film concentrations of ofloxacin were measured in 30 healthy women topically treated with 0.3% ofloxacin, in both eyes, four times daily for 10 1/2 days. Serum was collected before the f...


    pub_type: 杂志文章


    authors: Borrmann L,Tang-Liu DD,Kann J,Nista J,Lin ET,Frank J

    更新日期:1992-05-01 00:00:00

  • Ocular streptococcal infections.

    abstract::Streptococcal infections are an important cause of corneal ulcers, endophthalmitis, conjunctivitis, and dacryocystitis. We retrospectively reviewed 53 ocular streptococcal infections diagnosed and followed at Wills Eye Hospital between January 1, 1984, and July 1, 1986. Corneal ulcers (23 of 53; 43%) and endophthalmit...


    pub_type: 杂志文章


    authors: Jones S,Cohen EJ,Arentsen JJ,Laibson PR

    更新日期:1988-01-01 00:00:00

  • Penetrating keratoplasty for perforated corneal ulcers: preservation of iris by corneal debulking.

    abstract:PURPOSE:This study was designed to study an alternative technique of lamellar separation of corneal layers for therapeutic keratoplasty in place of an en bloc removal of host corneal button in eyes with perforated corneal ulcers with pseudocornea. METHODS:Twelve eyes with perforated corneal ulcers with pseudocornea in...


    pub_type: 杂志文章


    authors: Vajpayee RB,Singhvi A,Sharma N,Sinha R

    更新日期:2006-01-01 00:00:00

  • Endothelial keratoplasty without Descemet stripping after failed penetrating keratoplasty.

    abstract:PURPOSE:To evaluate outcomes of endothelial keratoplasty (EK) without Descemet membrane stripping for treatment of failed penetrating keratoplasty (PKP). METHODS:Retrospective cohort study of all eyes that underwent EK without Descemet membrane stripping for failed PKP at one institution between May 2008 and June 2010...


    pub_type: 杂志文章


    authors: Heitor de Paula F,Kamyar R,Shtein RM,Sugar A,Mian SI

    更新日期:2012-06-01 00:00:00

  • Cell Therapy of Corneal Diseases.

    abstract::Mesenchymal stem cells isolated from connective tissues are pluripotent and differentiate into phenotypes of connective tissue cell lineages (osteoblasts, chondrocytes, and adipocytes) in vitro and in vivo. They have been used to treat mouse models of connective tissue disease such as lumican-null (Lum) and mucopolysa...


    pub_type: 杂志文章,评审


    authors: Kao WW,Coulson-Thomas VJ

    更新日期:2016-11-01 00:00:00

  • Correlation between clinical in vivo confocal microscopic and ex vivo histopathologic findings of Salzmann nodular degeneration.

    abstract:PURPOSE:To report clinical, in vivo confocal microscopy and ex vivo histopathologic findings of Salzmann nodular degeneration (SND). METHODS:A 48-year-old woman with symptoms of ocular irritation and decreased visual acuity caused by SND in both eyes was treated by corneal scraping and phototherapeutic keratectomy (PT...


    pub_type: 杂志文章


    authors: Meltendorf C,Bühren J,Bug R,Ohrloff C,Kohnen T

    更新日期:2006-07-01 00:00:00

  • Autologous Descemet Stripping Automated Endothelial Keratoplasty to Eliminate Endothelial Rejection in Eyes at High Risk.

    abstract:PURPOSE:To determine whether autologous Descemet stripping endothelial keratoplasty is technically feasible and whether it eliminates the risk of endothelial rejection in "only eyes" at high risk of immunological rejection. METHODS:This is a prospective observational interventional study from 2016 to 2018 with a 24-mo...


    pub_type: 杂志文章


    authors: Myerscough J,Friehmann A,Bovone C,Busin M

    更新日期:2020-05-01 00:00:00

  • Trends in contact lens-related corneal ulcers at a tertiary referral center.

    abstract:PURPOSE:To evaluate the changes and trends in the number and characteristics of contact lens-related ulcers (CLRUs) and to compare the results with those of previously published series at our institution. METHODS:Medical records of all patients diagnosed with presumed bacterial corneal ulcers seen at the Cornea Servic...


    pub_type: 杂志文章


    authors: Yildiz EH,Airiani S,Hammersmith KM,Rapuano CJ,Laibson PR,Virdi AS,Hongyok T,Cohen EJ

    更新日期:2012-10-01 00:00:00

  • Efficacy of Corneal Collagen Cross-Linking for the Treatment of Keratoconus: A Systematic Review and Meta-Analysis.

    abstract:PURPOSE:To examine the efficacy of corneal collagen cross-linking (CXL) for the treatment of keratoconus (KCN). METHODS:A systemic literature review and meta-analysis of ocular functional and structural parameters of patients with KCN undergoing cross-linking procedures were performed using PubMed and the web of scien...


    pub_type: 杂志文章,meta分析,评审


    authors: Meiri Z,Keren S,Rosenblatt A,Sarig T,Shenhav L,Varssano D

    更新日期:2016-03-01 00:00:00

  • Adaptation of homeostatic ocular surface epithelium to chronic treatment with the opioid antagonist naltrexone.

    abstract:PURPOSE:To determine how ocular surface epithelium adjusts to an increase in cell replication after treatment with the opioid antagonist naltrexone (NTX). METHODS:Adult male rats were given twice daily injections of 30 mg/kg NTX or vehicle for 7 days. Outcomes of NTX administration included DNA synthesis (monitored wi...


    pub_type: 杂志文章


    authors: Zagon IS,Sassani JW,McLaughlin PJ

    更新日期:2006-08-01 00:00:00

  • In vivo corneal confocal microscopy in marfan syndrome.

    abstract:PURPOSE:To examine the cornea of patients with Marfan syndrome in comparison with a control group by using the in vivo confocal microscope. METHODS:Twenty-four eyes of 12 patients with Marfan syndrome had their corneas examined using the in vivo confocal microscope Heidelberg Retina Tomograph (HRT) II/Rostock Cornea M...


    pub_type: 杂志文章


    authors: Iordanidou V,Sultan G,Boileau C,Raphael M,Baudouin C,Marfan Study Group.

    更新日期:2007-08-01 00:00:00

  • Healing rate of corneal erosions: comparison of the effect of chloramphenicol eye drops and ointment and high-concentration hyaluronic acid in an animal model.

    abstract:PURPOSE:The aim of this study was to compare the effect of chloramphenicol eye drops or ointment, high-concentration hyaluronic acid, or no treatment on reepithelialization of corneal erosions in an experimental model. METHODS:Uniform 6-mm corneal erosions were created in 23 rabbit eyes. The rabbits were randomized to...


    pub_type: 杂志文章


    authors: Barequet IS,Harizman N,Ziv H,Rosner M

    更新日期:2014-10-01 00:00:00

  • Corneal Transplantation in New Zealand 2000 to 2009.

    abstract:PURPOSE:To quantify all minor/major adverse events in a large cohort of consecutive corneal transplants, particularly in respect to penetrating keratoplasty (PKP). METHODS:All corneal transplants in the Auckland region over a 10-year period (2000-2009) were identified through the New Zealand National Eye Bank. Relevan...


    pub_type: 杂志文章


    authors: Crawford AZ,Krishnan T,Ormonde SE,Patel DV,McGhee CN

    更新日期:2018-03-01 00:00:00