Abstract:
PURPOSE:To study the effect of topical cyclosporin A on herpetic stromal keratitis (HSK) in a mouse model. METHODS:The corneas of BALB/c mice were infected with herpes simplex type 1 virus. The mice were divided into 4 groups according to topical treatment methods: vehicle solution, 0.01% cyclosporin A, 0.1% cyclosporin A, and 1% cyclosporin A. The severity of stromal keratitis was graded clinically at 3, 7, 10, and 14 days after treatment. Histologic and immunohistochemical examinations were performed to analyze infiltrating inflammatory cells and T lymphocytes at 14 days after treatment. Flow cytometry was performed to count CD4 T cells at 14 days after treatment. RESULTS:On day 3 after treatment, there were no significant differences in mean severity scores of HSK between the vehicle and cyclosporin A-treated groups. On days 7, 10, and 14, the severity scores in the groups treated with 0.1% or 1% cyclosporin A decreased significantly compared with the vehicle group (P < 0.05). However, the scores in the group treated with 0.01% cyclosporin A did not change up to 14 days after treatment. By histologic and immunohistochemical analysis, a significant decrease in the total number of inflammatory cells and T lymphocytes was detected in the groups treated with 0.1% or 1% cyclosporin A. Flow cytometry also showed similar findings. CONCLUSIONS:Topical cyclosporin A effectively reduces stromal haze and inflammation in experimental HSK, and cyclosporin A eyedrops with a >0.1% concentration can be used for the treatment of HSK.
journal_name
Corneajournal_title
Corneaauthors
Yoon KC,Heo H,Kang IS,Lee MC,Kim KK,Park SH,Cho KOdoi
10.1097/ICO.0b013e318160602dsubject
Has Abstractpub_date
2008-05-01 00:00:00pages
454-60issue
4eissn
0277-3740issn
1536-4798pii
00003226-200805000-00012journal_volume
27pub_type
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