Coexistent congenital hereditary endothelial dystrophy and congenital glaucoma.

Abstract:

PURPOSE:To retrospectively evaluate the coexistence of congenital glaucoma with congenital hereditary endothelial dystrophy. METHODS:Ten infants presented to our hospital with diffuse corneal edema and bilaterally elevated intraocular pressure (IOP). These patients were diagnosed with congenital glaucoma. All patients underwent trabeculotomy with trabeculectomy for control of IOP. Although IOP was normalized in all patients, corneal edema persisted. These patients underwent penetrating keratoplasty, and the buttons were subjected to histopathologic examination. RESULTS:The corneal grafts remained clear in all patients. The histopathologic examination of the excised corneal buttons showed diffuse stromal edema, loss of the endothelial cell layer, and thickening of the posterior non-banded portion of the Descemet membrane, suggestive of congenital hereditary endothelial dystrophy. CONCLUSIONS:Congenital hereditary endothelial dystrophy may coexist with congenital glaucoma. This combination should be suspected where persistent and total corneal opacification fails to resolve after normalization of IOP.

journal_name

Cornea

journal_title

Cornea

authors

Ramamurthy B,Sachdeva V,Mandal AK,Vemuganti GK,Garg P,Sangwan VS

doi

10.1097/ICO.0b013e31804e4579

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

647-9

issue

6

eissn

0277-3740

issn

1536-4798

pii

00003226-200707000-00001

journal_volume

26

pub_type

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