Abstract:
PURPOSE:To retrospectively evaluate the coexistence of congenital glaucoma with congenital hereditary endothelial dystrophy. METHODS:Ten infants presented to our hospital with diffuse corneal edema and bilaterally elevated intraocular pressure (IOP). These patients were diagnosed with congenital glaucoma. All patients underwent trabeculotomy with trabeculectomy for control of IOP. Although IOP was normalized in all patients, corneal edema persisted. These patients underwent penetrating keratoplasty, and the buttons were subjected to histopathologic examination. RESULTS:The corneal grafts remained clear in all patients. The histopathologic examination of the excised corneal buttons showed diffuse stromal edema, loss of the endothelial cell layer, and thickening of the posterior non-banded portion of the Descemet membrane, suggestive of congenital hereditary endothelial dystrophy. CONCLUSIONS:Congenital hereditary endothelial dystrophy may coexist with congenital glaucoma. This combination should be suspected where persistent and total corneal opacification fails to resolve after normalization of IOP.
journal_name
Corneajournal_title
Corneaauthors
Ramamurthy B,Sachdeva V,Mandal AK,Vemuganti GK,Garg P,Sangwan VSdoi
10.1097/ICO.0b013e31804e4579subject
Has Abstractpub_date
2007-07-01 00:00:00pages
647-9issue
6eissn
0277-3740issn
1536-4798pii
00003226-200707000-00001journal_volume
26pub_type
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