Abstract:
:The objective of this study was to compare four methods of counting corneal endothelial cell density using the Topcon SP 1000 microscope and Image-NET digital graphic software. Two independent observers quantified cell density from 63 endothelial photomicrographs using the various standardized techniques. The first method was that suggested for use with Topcon SP 1000, employing five different reference grids to compare subjectively with the endothelial cell density of the unknown sample. The other three methods involved the automated, semiautomated, and manual procedures developed for use with the Image-NET system software. The manual Image-NET system is presently considered to yield accurate cell morphology data. Confidence limits and standard errors of mean differences between values obtained by different methods were used to evaluate agreement and reproducibility of computerized methods. Sensitivity and specificity were calculated for two different threshold limits of endothelial cell density. Results showed that the automated Image-NET system is not reliable for clinical use because of its poor agreement with other methods and its lack of sensitivity and specificity at the selected threshold limits of endothelial cell density. The comparative Topcon method of using reference grids, although inexpensive and accurate for 500 cell/mm2 increments, was considered too imprecise for most clinical situations. The semiautomated Image-NET system, in half the analysis time required by the manual method, provided endothelial cell count estimates that were not clinically different from those obtained with manual counting.
journal_name
Corneajournal_title
Corneaauthors
Vecchi M,Braccio L,Orsoni JGdoi
10.1097/00003226-199605000-00008subject
Has Abstractpub_date
1996-05-01 00:00:00pages
271-7issue
3eissn
0277-3740issn
1536-4798journal_volume
15pub_type
杂志文章相关文献
CORNEA文献大全abstract:PURPOSE:To assess the characteristics of BioMask as a potential masking agent for use with the excimer laser. METHOD:We addressed ablation rate, smoothness, ease of use, dioptric shift, treatment of standardized irregular topography, and ability of BioMask to induce dioptric change in vivo. RESULTS:BioMask ablates at...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199903000-00003
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:To evaluate changes in the anterior chamber of eyes that have undergone Descemet membrane endothelial keratoplasty (DMEK) and to identify factors that affect these changes. METHODS:This retrospective study included 25 pseudophakic eyes of 25 patients who underwent DMEK. We determined the preoperative and posto...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002535
更新日期:2020-09-29 00:00:00
abstract:PURPOSE:The compositional, structural, and functional relationships of meibum may provide insights into the loss of tear film stability. Although the conformation of meibum lipids has been studied rigorously, that of tear lipids has not. METHODS:Tear lipids (TLHSCT) and meibum (MHSCT) from patients who had hematopoiet...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002095
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To evaluate the prevalence of positive microbiology results (culture and/or Gram stain) in donor cornea tissue with newer transplant methods and to assess if the results subsequently correlate with higher incidence of clinical infection. METHODS:A retrospective review of the microbiology records of 569 consecu...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3182542368
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To determine if Cornisol is as effective as Optisol-GS as an intermediate-term corneal storage medium. METHODS:A prospective, in vitro, randomized, partially masked study using paired donor corneas. Optical grade tissues not suitable for surgery were used. After performing baseline slit lamp evaluation, one ti...
journal_title:Cornea
pub_type: 杂志文章,随机对照试验
doi:10.1097/ICO.0000000000000912
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the visual function information obtained from multiple reading tests in a dry eye population. METHODS:In this case-control, single-center clinical research center-based study, 15 subjects with dry eye (mean age 65 years) and 10 normal subjects (mean age 40 years) were incl...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000490
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:To report a case of successful medical treatment with oral posaconazole in refractory fungal keratitis caused by Paecilomyces lilacinus. METHODS:Case report. RESULTS:A 57-year-old male, soft contact lens wearer presented with irritation, pain, photophobia, and reduced vision. Slit-lamp examination showed a la...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000143
更新日期:2014-07-01 00:00:00
abstract::Phacoemulsification has become the most commonly used procedure in cataract surgery owing to the development of new devices and surgical techniques; however, corneal endothelial damage still represents a serious complication. Although several factors are known to cause corneal endothelial damage, effects of irrigating...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000990
更新日期:2016-11-01 00:00:00
abstract::A modified relaxing incision technique for postkeratoplasty astigmatism is described in this article. Following the initial, standard relaxing incision techniques, a planned spreading and recutting of the initial relaxing incision was performed at 1-3-week intervals following the initial surgery. The wound may be deep...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:To evaluate the long-term changes in anterior and posterior corneal irregular astigmatism and curvatures after small incision lenticule extraction (SMILE). METHODS:Fifty eyes of 28 patients underwent SMILE for myopic astigmatism. All procedures were performed using the VisuMax® femtosecond laser. A Scheimpflug...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001532
更新日期:2018-07-01 00:00:00
abstract::The fellow normal-appearing eyes of 23 patients with unilateral aphakic bullous keratopathy were examined by wide-field specular microscopy and pachymetry. All patients had: pseudophakic or aphakic bullous keratopathy in one eye; unoperated fellow eye on no medication; no other ocular disease; and no endothelial gutta...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:To report the association between colonization of contact lenses with Streptococcus pneumoniae and the observation of corneal infiltrative events in a group of patients wearing disposable hydrogel lenses on an extended-wear schedule. METHODS:In a prospective clinical trial, 330 patients wore disposable hydroge...
journal_title:Cornea
pub_type: 临床试验,杂志文章
doi:10.1097/00003226-199905000-00008
更新日期:1999-05-01 00:00:00
abstract:PURPOSE:To present a new treatment modality for recurrent corneal melting in a patient with a Boston type I keratoprosthesis (B-KPro) including in situ corneal cross-linking (CXL) and lamellar keratoplasty (LKP) as combined treatment. METHODS:Case report. RESULTS:Our report concerns a 27-year-old man whose case histo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000830
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare the cellular susceptibility patterns and morphologic changes in the corneal endothelium associated with the use of fourth-generation fluoroquinolones. METHOD:Endothelial susceptibility was assessed through intracameral injection of besifloxacin, gatifloxacin, and moxifloxac...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000967
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To identify risk factors for ocular graft-versus-host disease (oGVHD) in children with graft-versus-host disease (GVHD). METHODS:This retrospective cohort study identified 38 children diagnosed with GVHD who underwent an ophthalmological examination. Survival to onset of oGVHD after transplant was analyzed usi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002659
更新日期:2021-01-18 00:00:00
abstract:PURPOSE:To evaluate the surface characteristics of lenticules created by small-incision lenticule extraction (SMILE) with different cap thicknesses. METHODS:This prospective study included 20 consecutive patients who underwent bilateral SMILE. Surface regularity of the extracted corneal lenticule was analyzed using sc...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001404
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To describe two cases of secondary congenital aphakia in association with Peters anomaly. METHODS:Two infants were noted to have corneal opacification at birth. Each child was found to have Peters anomaly requiring corneal transplantation in 1 or both eyes. RESULTS:Each child underwent penetrating keratoplast...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000134187.19117.6a
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To estimate the prevalence of meibomian gland dysfunction (MGD) in the Japanese population using new diagnostic criteria, including lid margin abnormalities and signs of occlusion of the meibomian gland orifices as essential signs. METHODS:The participants were consecutive patients scheduled for cataract surge...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001208
更新日期:2017-06-01 00:00:00
abstract::Bacterial viability in bacterial adherence to new soft contact lenses (SCLs) was studied by exposing polymacon and lidofilcon A lenses to Pseudomonas aeruginosa: L, live, untreated bacteria; H, bacteria heated for 1 h at 100 degrees C; and P, bacteria treated with 3% hydrogen peroxide for 1 h. Cultures of groups L, H,...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:To report 2 cases of corneal perforation associated with a persistent epithelial defect (PED), which were treated with eye drops containing the fibronectin-derived peptide PHSRN (Pro-His-Ser-Arg-Asn). METHODS:A 67-year-old man and a 58-year-old man presented with corneal perforation associated with a PED cause...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000592
更新日期:2015-11-01 00:00:00
abstract::The treatment of herpes simplex keratitis has ranged from simple debridement to the use of prototypic antiviral agents specific to the herpes family, such as acyclovir. The various treatment modalities for dendritic keratitis, for the most part, have been effective. However, in recent years numerous reports of antivir...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199505000-00017
更新日期:1995-05-01 00:00:00
abstract::The iridocorneal endothelial (ICE) syndrome is potentially a blinding condition as a result of glaucoma and/or corneal decompensation. The basic pathology seems to be in the corneal endothelium, which many studies confirm takes on a characteristic slit lamp appearance of hammered silver and image reversal with the spe...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199105000-00009
更新日期:1991-05-01 00:00:00
abstract:PURPOSE:To assess the effects of corneal collagen cross-linking (CXL) on contrast sensitivity (CS), visual acuity, and corneal topography investigating possible predictors of efficacy. METHODS:Sixty-eight eyes of 34 patients with progressive keratoconus were enrolled in this prospective study. CXL was performed in one...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31826672e2
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To report 2 cases of cornea verticillata (CV) after vandetanib treatment for medullary thyroid carcinoma (MTC). METHODS:In this retrospective interventional, case-report study, 2 patients who under vandetanib treatment for MTC were referred to our ophthalmology department because of vision complaints. Both sub...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001560
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To describe the incidence and prevalence of glaucoma in a patient population with severe ocular surface disease (OSD). METHODS:A retrospective case series was compiled from all charts of patients in the Cincinnati Eye Institute/University of Cincinnati and University of Minnesota population with a diagnosis of...
journal_title:Cornea
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ico.0000220776.93852.d9
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:To report a case of delayed bilateral Descemet's detachment with spontaneous resolution in one eye following successful treatment of the fellow eye. METHOD:Case report. RESULTS:A 78-year-old male who underwent uncomplicated bilateral cataract extraction with phacoemulsification developed delayed bilateral Des...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318197eef1
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Corneal lesions such as ulcers and erosions are major complications observed in patients with severe ocular allergic diseases. We aimed to look into the relationship between specific clinical conjunctival findings and the severity of corneal complications. METHODS:Thirty eyes of 6 patients with vernal kerato...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000114836.13127.45
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:To study the possible changes in Scheimpflug corneal densitometry 6 months after mitomycin C-augmented trabeculectomy and to compare these measurements with healthy controls. METHODS:Corneal densitometry was monitored with the Pentacam HR3 before and 6 months after first-time uncomplicated mitomycin C-augmente...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002439
更新日期:2020-07-27 00:00:00
abstract:PURPOSE:Dry eye syndrome (DES) is a common eye disease caused by tear deficiency or excessive tear evaporation. Because the tear film layers play a major role in the pathogenesis of the evaporative dry eye, some previous articles have suggested the possible mechanism of dyslipidemia and DES. However, the previous resul...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002133
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To present the clinical outcome of 2 cases of severe dry eye associated with Nivolumab, with 1 case progressing to corneal perforation. DESIGN:Case report. CASE 1:: A 58-year-old man with metastatic melanoma was referred for the management of severe bilateral dry eyes after undergoing his sixth cycle of Nivol...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000724
更新日期:2016-03-01 00:00:00