Endothelial rejection following penetrating keratoplasty using Healon or BSS.

Abstract:

:In order to evaluate the effect of a commonly used sodium hyaluronate preparation (Healon, Pharmacia AB, Uppsala, Sweden) on the incidence of endothelial rejection, endothelial cell loss, intraocular pressure, and corneal thickness after penetrating keratoplasty, we conducted a randomized clinical trial. Patients were allocated to receive Healon (n = 41) or BSS (Alcon Laboratories, Inc., Fort Worth, TX, U.S.A.; n = 37) during surgery. At 1 year after surgery, the Kaplan-Meier estimate of the proportion remaining free of endothelial rejection was 78.1% (SE 6.5%) in the Healon group, and 70.6% (SE 7.9%) in the BSS group. Survival analysis showed no overall difference in endothelial rejection between groups. The percent loss in endothelial cell density showed substantial variability within each group, but for those followed 2 years after surgery, the amount of loss was significantly less in Healon-treated patients (17.3% versus 30.2%). Four Healon patients required medication for intraocular pressure rises in the early postoperative period, and the average intraocular pressure 1 day after surgery was greater in the Healon group (18.2 versus 13.7 mm Hg). Corneal thickness was slightly greater in patients receiving Healon, but no clinically important differences were noted.

journal_name

Cornea

journal_title

Cornea

authors

Musch DC,Meyer RF,Sugar A,Soong HK

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

305-11

issue

4

eissn

0277-3740

issn

1536-4798

journal_volume

9

pub_type

临床试验,杂志文章,随机对照试验

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