Abstract:
PURPOSE:Ocular local anesthetics currently used in routine clinical practice for corneal anesthesia are short acting and their ability to delay corneal healing makes them unsuitable for long-term use. In this study, we examined the effect of the site 1 sodium channel blocker tetrodotoxin (TTX) on the duration of corneal anesthesia, applied with either proparacaine (PPC) or the chemical permeation enhancer octyl-trimethyl ammonium bromide (OTAB). The effect of test solutions on corneal healing was also studied. METHODS:Solutions of TTX, PPC, and OTAB, singly or in combination, were applied topically to the rat cornea. The blink response, an indirect measure of corneal sensitivity, was recorded using a Cochet-Bonnet esthesiometer, and the duration of corneal anesthesia was calculated. The effect of test compounds on the rate of corneal epithelialization was studied in vivo after corneal debridement. RESULTS:Combination of TTX and PPC resulted in corneal anesthesia that was 8 to 10 times longer in duration than that from either drug administered alone, whereas OTAB did not prolong anesthesia. The rate of corneal healing was moderately delayed after coadministration of TTX and PPC. CONCLUSIONS:Coadministration of TTX and PPC significantly prolonged corneal anesthesia, but in view of delayed corneal reepithelialization, caution is suggested in the use of the drug combination.
journal_name
Corneajournal_title
Corneaauthors
Wang L,Shankarappa SA,Tong R,Ciolino JB,Tsui JH,Chiang HH,Kohane DSdoi
10.1097/ICO.0b013e31828cbfe6subject
Has Abstractpub_date
2013-07-01 00:00:00pages
1040-5issue
7eissn
0277-3740issn
1536-4798journal_volume
32pub_type
杂志文章相关文献
CORNEA文献大全abstract:PURPOSE:To describe the outcomes of Descemet membrane endothelial keratoplasty (DMEK) performed in amblyopic aged (younger than 8 years) children. METHODS:This is a single-center retrospective study, including 11 eyes (7 congenital hereditary endothelial dystrophy and 4 congenital glaucoma) of 6 children in amblyopic ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002540
更新日期:2020-09-16 00:00:00
abstract:PURPOSE:To investigate if the peripheral corneal endothelium that is discarded after the preparation of preloaded Descemet membrane endothelial keratoplasty (DMEK) grafts for transplantation could be successfully used for corneal endothelial cell culture. METHODS:Complete Descemet membrane-endothelial complex (11.00 m...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001998
更新日期:2019-09-01 00:00:00
abstract::Confocal microscopy provides a new, noninvasive way of imaging the human cornea in vivo. One of its most important clinical uses is the diagnosis and management of infectious keratitis. The authors used tandem scanning confocal microscopy to image the corneas in two culture-proven cases of Aspergillus keratitis. Funga...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:This study investigated the topographic corneal thickness in four groups of Hong Kong Chinese. METHODS:The corneal thickness was determined with an ultrasound pachometer mounted on a X-Y plate. A head rest was used to reduce further any movement from the subject during the measurement. After the central cornea...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199807000-00008
更新日期:1998-07-01 00:00:00
abstract:PURPOSE:To assess whether omega-3 fatty acid (FA) supplementation is more efficacious than placebo in amelioration of signs and symptoms of dry eye disease. METHODS:We performed a systematic literature search in PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials databases. We included r...
journal_title:Cornea
pub_type: 杂志文章,meta分析
doi:10.1097/ICO.0000000000001884
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To develop a rat model of chronic Acanthamoeba polyphaga keratitis suitable for pharmacologic assessment of therapeutic agents. METHODS:An A. polyphaga isolate (ATCC #50495) was grown in peptone-yeast extract-glucose medium. Five-weeks-old, Sprague-Dawley male rats were injected with 10(3) or 10(4) trophozoite...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000214213.37447.11
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:We aimed to evaluate a new technique using a thermosensitive glue coating for impression cytology of the ocular surface. METHODS:We prepared plasma polymerized N-isopropyl acrylamide (pNIPAM)-coated parylene C (poly(monochloro-p-xylylene)) films to obtain cytological samples from the conjunctival surface. We c...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318196706d
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:Hyperglycemia in diabetes mellitus (DM) might induce changes in corneal biomechanics. Therefore, biomechanical properties of the cornea were measured using the ocular response analyzer and the Corvis ST. METHODS:In the study, 35 eyes of 35 diabetic patients were included. After an ophthalmological examination,...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001879
更新日期:2019-05-01 00:00:00
abstract::This trial was a randomized, double-masked, crossover study during which patients with keratoconjunctivitis sicca underwent 6 weeks of treatment with either cyclosporine 1% ophthalmic ointment or placebo followed by 6 weeks of the alternative treatment. Washout periods using only unpreserved artificial tears preceded ...
journal_title:Cornea
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00003226-199307000-00007
更新日期:1993-07-01 00:00:00
abstract::The iridocorneal-endothelial (ICE) syndrome is characterised clinically by a "hammered-silver" appearance of the corneal endothelium, corneal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed "ICE cells." The pu...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Four patients had removal of their epikeratoplasty lenticules for unsatisfactory visual results. This was out of a consecutive series of 36 eyes. Three eyes were myopic and one was aphakic. In all four eyes, there was significant corneal steepening with an average increase in myopia of 2.4 diopters and an average incr...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract:PURPOSE:To compare the outcomes and complications of Epi-Bowman blunt keratectomy (EBK) using a blunt epikeratome (Epi-Clear, Orca Surgical, Israel), with alcohol delamination of the corneal epithelium during photorefractive keratectomy (PRK) in contralateral eyes. METHODS:This prospective, randomized contralateral ey...
journal_title:Cornea
pub_type: 杂志文章,随机对照试验
doi:10.1097/ICO.0000000000001863
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To report a case of nevirapine-induced Stevens-Johnson syndrome (SJS) misdiagnosed as viral keratitis. METHODS:A 35-year-old AIDS patient, on antiretroviral therapy (ART) with stavudine, nevirapine, and lamivudine, developed bilateral ocular congestion and irritation. He was being treated elsewhere for bilater...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31815b941b
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:To compare the outcome of bifold forceps and cartridge injector suture pull-through insertion techniques for Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS:A retrospective review was conducted of the medical records of all patients treated with DSAEK at the University of Iowa Hospitals ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181eadb84
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:The normal cornea is devoid of blood and lymphatic vessels but can become vascularized secondary to a variety of corneal diseases and surgical manipulations. Whereas corneal (hem)angiogenesis, i.e., the outgrowth of new blood vessels from preexisting limbal vessels, is obvious both clinically and histologically...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/00003226-200304000-00021
更新日期:2003-04-01 00:00:00
abstract::Corneal intraepithelial neoplasia (CIN) is the term applied by some authors to the spectrum of disease ranging from mild dysplasia to carcinoma in situ. Such lesions usually are associated with dysplastic or neoplastic processes at the limbus or adjacent conjunctiva; isolated corneal dysplasia is rare. Clinically, CIN...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the outcome of penetrating keratoplasties, at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany, using organ-cultured donor corneas and to identify preoperative risk factors, which may influence the event of graft failure. METHODS:In this study, 3...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000225
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To compare paired human corneas after storage at 4 degrees C in Chen medium (CM) and Optisol-GS medium (OM) for 7, 10, 14, and 21 days. METHODS:One cornea of each pair from nine human donors was randomly stored in either CM or OM, with its mate cornea stored in the other medium. Three pairs of corneas were sto...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200011000-00005
更新日期:2000-11-01 00:00:00
abstract:PURPOSE:To report a case of ocular manifestations after a primary varicella infection. METHODS:Review of the literature and a case report of a 10-year-old male patient with history of blurry vision and an enlarged pupil 2 months after a varicella infection. Examination revealed uveitis, interstitial keratitis, and int...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000224651.19837.6c
更新日期:2006-08-01 00:00:00
abstract::Corneal neovascularization complicates many anterior segment diseases. Corneal laser photocoagulation using yellow light (577 nm) has been shown to reduce corneal neovascularization. No histopathologic studies of the effects of this treatment on the eye have been reported, however. Target (cornea) and nontarget (iris,...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199305000-00001
更新日期:1993-05-01 00:00:00
abstract::Limbal allograft transplantation was performed consecutively in 16 eyes with thermal or chemical burns (n = 5), Terrien's degeneration (n = 2), congenital sclerocornea (n = 1), Stevens-Johnson syndrome (n = 1), and chronic keratoconjunctivitis (n = 7), by transplanting randomly selected cadaver limbocorneal grafts to ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199409000-00003
更新日期:1994-09-01 00:00:00
abstract:PURPOSE:To examine the carbohydrate sulfotransferase 6 (CHST6) gene in Chinese patients with macular corneal dystrophy (MCD). METHODS:Nineteen unrelated Chinese families with MCD, including 24 patients and 3 unaffected relatives, were examined. Genomic DNA was extracted from peripheral blood leukocytes. The coding reg...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181ca2e74
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:To assess the characteristics of BioMask as a potential masking agent for use with the excimer laser. METHOD:We addressed ablation rate, smoothness, ease of use, dioptric shift, treatment of standardized irregular topography, and ability of BioMask to induce dioptric change in vivo. RESULTS:BioMask ablates at...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199903000-00003
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:To assess the effect of cataract surgery on semiautomated human corneal endothelial cell density (ECD) estimation using noncontact specular microscopy. METHODS:In this prospective clinical study, 62 consecutive patients undergoing cataract surgery were studied. To evaluate possible variations of accuracy and a...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000141234.48967.e3
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:To evaluate the prevalence of different topographic patterns in refractive surgery candidates and to estimate the extent of candidate rejection based on topography alone. METHODS:We performed a retrospective evaluation of videokeratographies of previously unoperated refractive surgery candidates. The defined t...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000121699.74077.f0
更新日期:2004-08-01 00:00:00
abstract:PURPOSE:Ocular cicatricial pemphigoid (OCP) is a rare systemic autoimmune disease and a potentially blinding subepithelial blistering disorder. The purpose of this study was to describe the clinical spectrum of the disease and to assess the efficacy and safety of immunosuppressive agents in a cohort of patients with OC...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0000000000002080
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:To examine the immediate effect of ocular rubbing on corneal topography. METHODS:Corneal topography and analysis were performed before, immediately after, and 5 minutes after eyelid rubbing in 29 volunteers without ocular disease. RESULTS:The surface regularity index increased from a baseline of 0.24 to 0.91 ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200211000-00004
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:To review the clinical course, treatment, and visual outcomes of keratitis with endophthalmitis caused by the filamentary fungus Fusarium. METHOD:One hundred fifty-nine cases of Fusarium keratitis at Bascom Palmer Eye Institute between January 1, 1987 and August 21, 2000 were reviewed. Ten patients with cultur...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200305000-00004
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To determine the benefit of bilateral penetrating keratoplasty with regard to binocular vision. METHODS:We compared patients who underwent corneal transplantation bilaterally with patients who had successful corneal transplantation in one eye and corneal disease in the other eye. Specifically, changes in fusio...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200107000-00006
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:To investigate the in vivo, corneal, biomechanical changes after corneal collagen cross-linking (CXL) using the Ocular Response Analyzer (ORA) in patients with keratoconus and post-laser in situ keratomileusis (LASIK) ectasia. METHODS:Single-center, prospective, randomized, controlled, clinical trial. After CX...
journal_title:Cornea
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ICO.0b013e31821eea66
更新日期:2012-01-01 00:00:00