Topical drug formulations for prolonged corneal anesthesia.

Abstract:

PURPOSE:Ocular local anesthetics currently used in routine clinical practice for corneal anesthesia are short acting and their ability to delay corneal healing makes them unsuitable for long-term use. In this study, we examined the effect of the site 1 sodium channel blocker tetrodotoxin (TTX) on the duration of corneal anesthesia, applied with either proparacaine (PPC) or the chemical permeation enhancer octyl-trimethyl ammonium bromide (OTAB). The effect of test solutions on corneal healing was also studied. METHODS:Solutions of TTX, PPC, and OTAB, singly or in combination, were applied topically to the rat cornea. The blink response, an indirect measure of corneal sensitivity, was recorded using a Cochet-Bonnet esthesiometer, and the duration of corneal anesthesia was calculated. The effect of test compounds on the rate of corneal epithelialization was studied in vivo after corneal debridement. RESULTS:Combination of TTX and PPC resulted in corneal anesthesia that was 8 to 10 times longer in duration than that from either drug administered alone, whereas OTAB did not prolong anesthesia. The rate of corneal healing was moderately delayed after coadministration of TTX and PPC. CONCLUSIONS:Coadministration of TTX and PPC significantly prolonged corneal anesthesia, but in view of delayed corneal reepithelialization, caution is suggested in the use of the drug combination.

journal_name

Cornea

journal_title

Cornea

authors

Wang L,Shankarappa SA,Tong R,Ciolino JB,Tsui JH,Chiang HH,Kohane DS

doi

10.1097/ICO.0b013e31828cbfe6

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

1040-5

issue

7

eissn

0277-3740

issn

1536-4798

journal_volume

32

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Descemet Membrane Endothelial Keratoplasty in Children.

    abstract:PURPOSE:To describe the outcomes of Descemet membrane endothelial keratoplasty (DMEK) performed in amblyopic aged (younger than 8 years) children. METHODS:This is a single-center retrospective study, including 11 eyes (7 congenital hereditary endothelial dystrophy and 4 congenital glaucoma) of 6 children in amblyopic ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002540

    authors: Pereira NC,Pereira Gomes JÁ,Tonin C,Verardo FO,Felippe RS,Dos Santos Forseto A

    更新日期:2020-09-16 00:00:00

  • Culturing Discarded Peripheral Human Corneal Endothelial Cells From the Tissues Deemed for Preloaded DMEK Transplants.

    abstract:PURPOSE:To investigate if the peripheral corneal endothelium that is discarded after the preparation of preloaded Descemet membrane endothelial keratoplasty (DMEK) grafts for transplantation could be successfully used for corneal endothelial cell culture. METHODS:Complete Descemet membrane-endothelial complex (11.00 m...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001998

    authors: Parekh M,Romano V,Ruzza A,Kaye SB,Ponzin D,Ahmad S,Ferrari S

    更新日期:2019-09-01 00:00:00

  • Diagnosis of Aspergillus keratitis in vivo with confocal microscopy.

    abstract::Confocal microscopy provides a new, noninvasive way of imaging the human cornea in vivo. One of its most important clinical uses is the diagnosis and management of infectious keratitis. The authors used tandem scanning confocal microscopy to image the corneas in two culture-proven cases of Aspergillus keratitis. Funga...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Winchester K,Mathers WD,Sutphin JE

    更新日期:1997-01-01 00:00:00

  • The corneal-thickness profile in Hong Kong Chinese.

    abstract:PURPOSE:This study investigated the topographic corneal thickness in four groups of Hong Kong Chinese. METHODS:The corneal thickness was determined with an ultrasound pachometer mounted on a X-Y plate. A head rest was used to reduce further any movement from the subject during the measurement. After the central cornea...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199807000-00008

    authors: Lam AK,Douthwaite WA

    更新日期:1998-07-01 00:00:00

  • Efficacy of Omega-3 Fatty Acid Supplementation for Treatment of Dry Eye Disease: A Meta-Analysis of Randomized Clinical Trials.

    abstract:PURPOSE:To assess whether omega-3 fatty acid (FA) supplementation is more efficacious than placebo in amelioration of signs and symptoms of dry eye disease. METHODS:We performed a systematic literature search in PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials databases. We included r...

    journal_title:Cornea

    pub_type: 杂志文章,meta分析

    doi:10.1097/ICO.0000000000001884

    authors: Giannaccare G,Pellegrini M,Sebastiani S,Bernabei F,Roda M,Taroni L,Versura P,Campos EC

    更新日期:2019-05-01 00:00:00

  • A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents.

    abstract:PURPOSE:To develop a rat model of chronic Acanthamoeba polyphaga keratitis suitable for pharmacologic assessment of therapeutic agents. METHODS:An A. polyphaga isolate (ATCC #50495) was grown in peptone-yeast extract-glucose medium. Five-weeks-old, Sprague-Dawley male rats were injected with 10(3) or 10(4) trophozoite...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000214213.37447.11

    authors: Vasseneix C,Gargala G,François A,Hellot MF,Duclos C,Muraine M,Benichou J,Ballet JJ,Brasseur G,Favennec L

    更新日期:2006-06-01 00:00:00

  • Conjunctival impression cytology by using a thermosensitive adhesive: polymerized N-isopropyl acrylamide.

    abstract:PURPOSE:We aimed to evaluate a new technique using a thermosensitive glue coating for impression cytology of the ocular surface. METHODS:We prepared plasma polymerized N-isopropyl acrylamide (pNIPAM)-coated parylene C (poly(monochloro-p-xylylene)) films to obtain cytological samples from the conjunctival surface. We c...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318196706d

    authors: Tunc M,Yildirim U,Yuksel H,Cheng X,Humayun M,Ratner B

    更新日期:2009-08-01 00:00:00

  • Measurement of Corneal Biomechanical Properties in Diabetes Mellitus Using the Ocular Response Analyzer and the Corvis ST.

    abstract:PURPOSE:Hyperglycemia in diabetes mellitus (DM) might induce changes in corneal biomechanics. Therefore, biomechanical properties of the cornea were measured using the ocular response analyzer and the Corvis ST. METHODS:In the study, 35 eyes of 35 diabetic patients were included. After an ophthalmological examination,...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001879

    authors: Ramm L,Herber R,Spoerl E,Pillunat LE,Terai N

    更新日期:2019-05-01 00:00:00

  • Pilot trial of cyclosporine 1% ophthalmic ointment in the treatment of keratoconjunctivitis sicca.

    abstract::This trial was a randomized, double-masked, crossover study during which patients with keratoconjunctivitis sicca underwent 6 weeks of treatment with either cyclosporine 1% ophthalmic ointment or placebo followed by 6 weeks of the alternative treatment. Washout periods using only unpreserved artificial tears preceded ...

    journal_title:Cornea

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003226-199307000-00007

    authors: Laibovitz RA,Solch S,Andriano K,O'Connell M,Silverman MH

    更新日期:1993-07-01 00:00:00

  • The histopathology of the iridocorneal-endothelial syndrome.

    abstract::The iridocorneal-endothelial (ICE) syndrome is characterised clinically by a "hammered-silver" appearance of the corneal endothelium, corneal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed "ICE cells." The pu...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Levy SG,Kirkness CM,Moss J,Ficker L,McCartney AC

    更新日期:1996-01-01 00:00:00

  • Corneal steepening after epikeratoplasty.

    abstract::Four patients had removal of their epikeratoplasty lenticules for unsatisfactory visual results. This was out of a consecutive series of 36 eyes. Three eyes were myopic and one was aphakic. In all four eyes, there was significant corneal steepening with an average increase in myopia of 2.4 diopters and an average incr...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Nirankari VS

    更新日期:1989-12-01 00:00:00

  • Epi-Bowman Blunt Keratectomy Versus Diluted EtOH Epithelial Removal in Myopic Photorefractive Keratectomy: A Prospective Contralateral Eye Study.

    abstract:PURPOSE:To compare the outcomes and complications of Epi-Bowman blunt keratectomy (EBK) using a blunt epikeratome (Epi-Clear, Orca Surgical, Israel), with alcohol delamination of the corneal epithelium during photorefractive keratectomy (PRK) in contralateral eyes. METHODS:This prospective, randomized contralateral ey...

    journal_title:Cornea

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ICO.0000000000001863

    authors: Vingopoulos F,Kanellopoulos AJ

    更新日期:2019-05-01 00:00:00

  • Nevirapine-induced Stevens-Johnson syndrome in an HIV patient.

    abstract:PURPOSE:To report a case of nevirapine-induced Stevens-Johnson syndrome (SJS) misdiagnosed as viral keratitis. METHODS:A 35-year-old AIDS patient, on antiretroviral therapy (ART) with stavudine, nevirapine, and lamivudine, developed bilateral ocular congestion and irritation. He was being treated elsewhere for bilater...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31815b941b

    authors: Jain V,Shome D,Natarajan S

    更新日期:2008-04-01 00:00:00

  • Comparison of bifold forceps and cartridge injector suture pull-through insertion techniques for Descemet stripping automated endothelial keratoplasty.

    abstract:PURPOSE:To compare the outcome of bifold forceps and cartridge injector suture pull-through insertion techniques for Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS:A retrospective review was conducted of the medical records of all patients treated with DSAEK at the University of Iowa Hospitals ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181eadb84

    authors: Wendel LJ,Goins KM,Sutphin JE,Wagoner MD

    更新日期:2011-03-01 00:00:00

  • Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology.

    abstract:PURPOSE:The normal cornea is devoid of blood and lymphatic vessels but can become vascularized secondary to a variety of corneal diseases and surgical manipulations. Whereas corneal (hem)angiogenesis, i.e., the outgrowth of new blood vessels from preexisting limbal vessels, is obvious both clinically and histologically...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/00003226-200304000-00021

    authors: Cursiefen C,Chen L,Dana MR,Streilein JW

    更新日期:2003-04-01 00:00:00

  • Keratinizing corneal intraepithelial neoplasia.

    abstract::Corneal intraepithelial neoplasia (CIN) is the term applied by some authors to the spectrum of disease ranging from mild dysplasia to carcinoma in situ. Such lesions usually are associated with dysplastic or neoplastic processes at the limbus or adjacent conjunctiva; isolated corneal dysplasia is rare. Clinically, CIN...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Brown HH,Glasgow BJ,Holland GN,Foos RY

    更新日期:1989-09-01 00:00:00

  • Donor-related risk factors and preoperative recipient-related risk factors for graft failure.

    abstract:PURPOSE:The aim of this study was to evaluate the outcome of penetrating keratoplasties, at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany, using organ-cultured donor corneas and to identify preoperative risk factors, which may influence the event of graft failure. METHODS:In this study, 3...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000225

    authors: Yu AL,Kaiser M,Schaumberger M,Messmer E,Kook D,Welge-Lussen U

    更新日期:2014-11-01 00:00:00

  • In vitro comparison of Chen medium and Optisol-GS medium for human corneal storage.

    abstract:PURPOSE:To compare paired human corneas after storage at 4 degrees C in Chen medium (CM) and Optisol-GS medium (OM) for 7, 10, 14, and 21 days. METHODS:One cornea of each pair from nine human donors was randomly stored in either CM or OM, with its mate cornea stored in the other medium. Three pairs of corneas were sto...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200011000-00005

    authors: Nelson LR,Hodge DO,Bourne WM

    更新日期:2000-11-01 00:00:00

  • Ocular manifestations after primary varicella infection.

    abstract:PURPOSE:To report a case of ocular manifestations after a primary varicella infection. METHODS:Review of the literature and a case report of a 10-year-old male patient with history of blurry vision and an enlarged pupil 2 months after a varicella infection. Examination revealed uveitis, interstitial keratitis, and int...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000224651.19837.6c

    authors: Fernández de Castro LE,Sarraf OA,Hawthorne KM,Solomon KD,Vroman DT

    更新日期:2006-08-01 00:00:00

  • Biomicroscopic and histopathologic observations after corneal laser photocoagulation in a rabbit model of corneal neovascularization.

    abstract::Corneal neovascularization complicates many anterior segment diseases. Corneal laser photocoagulation using yellow light (577 nm) has been shown to reduce corneal neovascularization. No histopathologic studies of the effects of this treatment on the eye have been reported, however. Target (cornea) and nontarget (iris,...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199305000-00001

    authors: Hemady RK,Baer JC,Foster CS

    更新日期:1993-05-01 00:00:00

  • Human allograft limbal transplantation for corneal surface reconstruction.

    abstract::Limbal allograft transplantation was performed consecutively in 16 eyes with thermal or chemical burns (n = 5), Terrien's degeneration (n = 2), congenital sclerocornea (n = 1), Stevens-Johnson syndrome (n = 1), and chronic keratoconjunctivitis (n = 7), by transplanting randomly selected cadaver limbocorneal grafts to ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199409000-00003

    authors: Tsai RJ,Tseng SC

    更新日期:1994-09-01 00:00:00

  • Mutation analysis of CHST6 gene in Chinese patients with macular corneal dystrophy.

    abstract:PURPOSE:To examine the carbohydrate sulfotransferase 6 (CHST6) gene in Chinese patients with macular corneal dystrophy (MCD). METHODS:Nineteen unrelated Chinese families with MCD, including 24 patients and 3 unaffected relatives, were examined. Genomic DNA was extracted from peripheral blood leukocytes. The coding reg...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181ca2e74

    authors: Liu Z,Tian X,Iida N,Fujiki K,Xie P,Wang W,Ma Z,Kanai A,Murakami A

    更新日期:2010-08-01 00:00:00

  • The BioMask for treatment of corneal surface irregularities with excimer laser phototherapeutic keratectomy.

    abstract:PURPOSE:To assess the characteristics of BioMask as a potential masking agent for use with the excimer laser. METHOD:We addressed ablation rate, smoothness, ease of use, dioptric shift, treatment of standardized irregular topography, and ability of BioMask to induce dioptric change in vivo. RESULTS:BioMask ablates at...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199903000-00003

    authors: Stevens SX,Bowyer BL,Sanchez-Thorin JC,Rocha G,Young DA,Rowsey JJ

    更新日期:1999-03-01 00:00:00

  • Influence of cataract surgery on corneal endothelial cell density estimation.

    abstract:PURPOSE:To assess the effect of cataract surgery on semiautomated human corneal endothelial cell density (ECD) estimation using noncontact specular microscopy. METHODS:In this prospective clinical study, 62 consecutive patients undergoing cataract surgery were studied. To evaluate possible variations of accuracy and a...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000141234.48967.e3

    authors: Wirbelauer C,Wollensak G,Pham DT

    更新日期:2005-03-01 00:00:00

  • Topographic patterns in refractive surgery candidates.

    abstract:PURPOSE:To evaluate the prevalence of different topographic patterns in refractive surgery candidates and to estimate the extent of candidate rejection based on topography alone. METHODS:We performed a retrospective evaluation of videokeratographies of previously unoperated refractive surgery candidates. The defined t...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000121699.74077.f0

    authors: Varssano D,Kaiserman I,Hazarbassanov R

    更新日期:2004-08-01 00:00:00

  • Clinical Characteristics and Outcomes of Ocular Cicatricial Pemphigoid: A Cohort Study and Literature Review.

    abstract:PURPOSE:Ocular cicatricial pemphigoid (OCP) is a rare systemic autoimmune disease and a potentially blinding subepithelial blistering disorder. The purpose of this study was to describe the clinical spectrum of the disease and to assess the efficacy and safety of immunosuppressive agents in a cohort of patients with OC...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0000000000002080

    authors: Fremont F,Pelissier-Suarez C,Fournié P,Porterie M,Thevenin A,Astudillo L,Paricaud K,Gualino V,Soler V,Pugnet G

    更新日期:2019-11-01 00:00:00

  • Corneal topography after ocular rubbing.

    abstract:PURPOSE:To examine the immediate effect of ocular rubbing on corneal topography. METHODS:Corneal topography and analysis were performed before, immediately after, and 5 minutes after eyelid rubbing in 29 volunteers without ocular disease. RESULTS:The surface regularity index increased from a baseline of 0.24 to 0.91 ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200211000-00004

    authors: Mansour AM,Haddad RS

    更新日期:2002-11-01 00:00:00

  • Advanced fusarium keratitis progressing to endophthalmitis.

    abstract:PURPOSE:To review the clinical course, treatment, and visual outcomes of keratitis with endophthalmitis caused by the filamentary fungus Fusarium. METHOD:One hundred fifty-nine cases of Fusarium keratitis at Bascom Palmer Eye Institute between January 1, 1987 and August 21, 2000 were reviewed. Ten patients with cultur...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200305000-00004

    authors: Dursun D,Fernandez V,Miller D,Alfonso EC

    更新日期:2003-05-01 00:00:00

  • Binocular vision recovery in bilateral keratoplasty.

    abstract:PURPOSE:To determine the benefit of bilateral penetrating keratoplasty with regard to binocular vision. METHODS:We compared patients who underwent corneal transplantation bilaterally with patients who had successful corneal transplantation in one eye and corneal disease in the other eye. Specifically, changes in fusio...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200107000-00006

    authors: Sampaio R,Held E,Cohen EJ,Grewal S,Rapuano CJ,Smith AF,Laibson PR

    更新日期:2001-07-01 00:00:00

  • In vivo biomechanical changes after corneal collagen cross-linking for keratoconus and corneal ectasia: 1-year analysis of a randomized, controlled, clinical trial.

    abstract:PURPOSE:To investigate the in vivo, corneal, biomechanical changes after corneal collagen cross-linking (CXL) using the Ocular Response Analyzer (ORA) in patients with keratoconus and post-laser in situ keratomileusis (LASIK) ectasia. METHODS:Single-center, prospective, randomized, controlled, clinical trial. After CX...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/ICO.0b013e31821eea66

    authors: Greenstein SA,Fry KL,Hersh PS

    更新日期:2012-01-01 00:00:00