Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology.

abstract：PURPOSE:To examine the cornea of patients with Marfan syndrome in comparison with a control group by using the in vivo confocal microscope. METHODS:Twenty-four eyes of 12 patients with Marfan syndrome had their corneas examined using the in vivo confocal microscope Heidelberg Retina Tomograph (HRT) II/Rostock Cornea M...

journal_title：Cornea

authors： Iordanidou V,Sultan G,Boileau C,Raphael M,Baudouin C,Marfan Study Group.

更新日期：2007-08-01 00:00:00

abstract：:The action of hydrogen peroxide on soluble proteins of the rat cornea has been evaluated. Two major corneal proteins are found to be oxidized by 10 mM hydrogen peroxide. Protein sequence and antibody recognition has shown one of the proteins to be albumin. Treatment of pure rat or human albumin with hydrogen peroxide ...

journal_title：Cornea

authors： Zhu L,Crouch RK

更新日期：1992-11-01 00:00:00

abstract：:Epithelium plays a very important structural and functional role in the cornea and conjunctiva. Evaluation of the epithelium is the first step in diagnosing many pathologic states. We have developed a new technique for the in vivo staining of nuclei of corneal and conjunctival epithelium in rabbits and guinea pigs. Se...

journal_title：Cornea

authors： Wander AH,Neumeister RD,Tschismadia I,Choromokos EA,Masukawa T

更新日期：1985-01-01 00:00:00

abstract：:Secondary corneal amyloidosis is a rare finding and only 17 cases have been reported in the literature. A case of unilateral secondary localized corneal amyloidosis is presented in a patient with bilateral interstitial keratitis and other stigmata of tertiary syphilis. ...

journal_title：Cornea

authors： Hill JC,Maske R,Bowen RM

更新日期：1990-04-01 00:00:00

abstract：:Twelve FITC-conjugated lectins were used to establish a reaction pattern with cellular and noncellular components in fresh-frozen and formalin-fixed paraffin sections of 11 normal human corneas. In frozen sections the epithelium demonstrated the most active lectin staining; keratocytes and endothelium stained to a les...

journal_title：Cornea

authors： Brandon DM,Nayak SK,Binder PS

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To study dry eye and analyze pathogenic factors in patients after cataract surgery. METHODS:A total of 37 patients (50 eyes) were studied by using a 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ25) and Ocular Surface Disease Index (OSDI) 3 days before and 1 week, 1 month, and 3 months a...

journal_title：Cornea

authors： Li XM,Hu L,Hu J,Wang W

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:To investigate the absorption of moxifloxacin into human aqueous humor after administration of moxifloxacin hydrochloride ophthalmic solution, 0.5% as base. METHODS:Cataract patients were randomly allocated to receive 1 drop every 15 minutes for 4 doses before surgery (group 1) or 1 drop 4 times per day on the...

journal_title：Cornea

authors： Katz HR,Masket S,Lane SS,Sall K,Orr SC,Faulkner RD,McCue BA,Dahlin DC

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:To evaluate if donor corneas obtained from deaths occurring because of septicemia can be used for corneal transplantation. STUDY DESIGN:Prospective study. METHODS:Eleven septicemic donor corneas were used in the study and 10 donor corneas from deaths because of causes other than septicemia were used as contro...

journal_title：Cornea

authors： Nagaraja H,Anandula V,Kugar T,Shivanna Y,Shetty R

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:This review discusses cellular senescence, the state in which normal cells do not respond to growth stimuli, and shows characteristic alterations in their cytologic and biochemical properties and their gene expression profiles. METHODS AND RESULTS:Cellular senescence is elicited by various stresses. It was rec...

journal_title：Cornea

authors： Ishikawa F

更新日期：2006-12-01 00:00:00

abstract：:Posterior polymorphous corneal dystrophy (PPD) is a rare bilateral, autosomal-dominant disease. The presence of the epitheliumlike endothelium and the thickening of Descemet's membrane by the posterior collagenous layer (PCL) has been reported in the majority of published cases. Reepithelialization of the posterior co...

journal_title：Cornea

authors： Sekundo W,Lee WR,Aitken DA,Kirkness CM

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:To compare the therapeutic effects of topical tumor necrosis factor (TNF)-α-stimulated gene/protein-6 (TSG-6) with those of cyclosporine and prednisolone eye drops in NOD.B10.H2 mice, a model for inflammation-mediated dry eye. METHODS:The 12-week-old NOD.B10.H2 mice were topically administered recombinant TSG-...

journal_title：Cornea

authors： Kim YJ,Ryu JS,Park SY,Lee HJ,Ko JH,Kim MK,Wee WR,Oh JY

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To compare endothelial cell analysis by the center and flex-center methods in corneas with guttae of differing severity and to determine the minimum countable cell number for using only the flex-center method. METHODS:Forty-seven eyes with corneal guttae and 50 age-matched normal controls were enrolled in the ...

journal_title：Cornea

authors： Huang J,Liu X,Tepelus TC,Nazikyan T,Chopra V,Sadda SR,Lee OL

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:This study explored a new method for removing thermosensitive acrylic punctal plugs from lacrimal puncta. METHODS:A total of 14 dry eye patients (14 eyes), who required the removal of thermosensitive acrylic punctal plugs from the lacrimal puncta because of serious complications, were recruited. Among the 14 p...

journal_title：Cornea

authors： Zhang M,Zhang X

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Corneal lesions such as ulcers and erosions are major complications observed in patients with severe ocular allergic diseases. We aimed to look into the relationship between specific clinical conjunctival findings and the severity of corneal complications. METHODS:Thirty eyes of 6 patients with vernal kerato...

journal_title：Cornea

authors： Tanaka M,Dogru M,Takano Y,Miyake-Kashima M,Asano-Kato N,Fukagawa K,Tsubota K,Fujishima H

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:To determine how ocular surface epithelium adjusts to an increase in cell replication after treatment with the opioid antagonist naltrexone (NTX). METHODS:Adult male rats were given twice daily injections of 30 mg/kg NTX or vehicle for 7 days. Outcomes of NTX administration included DNA synthesis (monitored wi...

journal_title：Cornea

authors： Zagon IS,Sassani JW,McLaughlin PJ

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:To identify potential donor, recipient, surgical, and postoperative factors that may influence survival and visual outcome of penetrating keratoplasty (PKP). METHODS:As part of a prospective longitudinal study, the electronic records of the New Zealand National Eye Bank were analyzed for the 10-year period fro...

journal_title：Cornea

authors： Patel HY,Ormonde S,Brookes NH,Moffatt SL,Sherwin T,Pendergrast DG,McGhee CN

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp. METHODS:We conducted a retrospective chart review. RESULTS:A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined m...

journal_title：Cornea

authors： Theoulakis P,Goldblum D,Zimmerli S,Muehlethaler K,Frueh BE

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:To evaluate the changes and trends in the number and characteristics of contact lens-related ulcers (CLRUs) and to compare the results with those of previously published series at our institution. METHODS:Medical records of all patients diagnosed with presumed bacterial corneal ulcers seen at the Cornea Servic...

journal_title：Cornea

authors： Yildiz EH,Airiani S,Hammersmith KM,Rapuano CJ,Laibson PR,Virdi AS,Hongyok T,Cohen EJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:To provide insight into the mechanism by which epidermal growth factor (EGF) stimulates corneal epithelial migration, we investigated the possible interaction between EGF and cyclic AMP (cAMP) signaling pathways during epithelial migration with an organ culture system for the rabbit cornea. METHODS:Rabbit corn...

journal_title：Cornea

authors： Nakamura M,Nishida T

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To compare the effects of levobunolol hydrochloride and timolol maleate on tear volume, precorneal tear film stability, and corneal epithelial barrier function in normal human eyes. SUBJECTS AND METHODS:The study population consisted of 14 healthy volunteers. To obtain pretreatment baseline values, we determin...

journal_title：Cornea

authors： Ishibashi T,Yokoi N,Kinoshita S

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:The 27-kDa heat shock protein (HSP27) has been implicated in wound healing in multiple tissues. We investigated the expression and localization of phosphorylated HSP27 during epithelial wound healing in the murine cornea. METHODS:Corneas of 8- to 10-week-old C57BL6 mice were wounded by epithelial debridement (...

journal_title：Cornea

authors： Jain S,De la Cruz J,Kang E,Kojima T,Chang JH,Kim JY

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:To report that spontaneous postkeratoplasty wound dehiscence or gaps caused by suture removal may occur years after penetrating and deep lamellar keratoplasty. METHODS:We retrospectively reviewed the medical records of 667 keratoplasty patients (890 eyes). This study included 8 eyes of 8 patients (3 men and 5 ...

journal_title：Cornea

authors： Fujii S,Matsumoto Y,Fukui M,Fujitake J,Kawakita T,Shimmura S,Tsubota K

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:To investigate the feasibility of using Brillouin microscopy for assessment of corneal edema in patients with Fuchs endothelial corneal dystrophy (FECD). Brillouin microscopy analyzes the frequency shift of light inelastically scattered by naturally occurring acoustic waves in a small volume of tissue. The resu...

journal_title：Cornea

authors： Eltony AM,Clouser F,Shao P,Pineda R 2nd,Yun SH

更新日期：2020-02-01 00:00:00

abstract：:This study attempts to measure the quantitative contribution of major chemical fractions of the whole bovine cornea to ultraviolet (UV) absorption between 240 and 300 nm, with special attention to the biologically significant range of 290-300 nm. The cornea was divided into water-insoluble, nonprotein small water-solu...

journal_title：Cornea

authors： Mitchell J,Cenedella RJ

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:Dry eye syndrome (DES) is a common eye disease caused by tear deficiency or excessive tear evaporation. Because the tear film layers play a major role in the pathogenesis of the evaporative dry eye, some previous articles have suggested the possible mechanism of dyslipidemia and DES. However, the previous resul...

journal_title：Cornea

authors： Choi HR,Lee JH,Lee HK,Song JS,Kim HC

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Pseudophakic/aphakic bullous keratopathy (PBK/ABK) human corneas accumulate an extracellular matrix glycoprotein tenascin-C (TN-C), an important modulator of cell adhesion and migration. Here, the purpose was to identify specific TN-C mRNA splice variants in normal and PBK/ABK human corneas. METHODS:Convention...

journal_title：Cornea

authors： Saghizadeh M,Khin HL,Bourdon MA,Kenney MC,Ljubimov AV

更新日期：1998-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate preparation outcomes of tissue prepared for Descemet membrane endothelial keratoplasty (DMEK) from diabetic and nondiabetic donors. METHODS:In this nonrandomized, consecutive case series, DMEK grafts were prepared from diabetic and nondiabetic donors by experienced technic...

journal_title：Cornea

authors： Greiner MA,Rixen JJ,Wagoner MD,Schmidt GA,Stoeger CG,Straiko MD,Zimmerman MB,Kitzmann AS,Goins KM

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:This study was designed to identify factors that predict longitudinal increases in corneal curvature as measured by the First Definite Apical Clearance Lens (FDACL) and flatter keratometric reading (Flat K) in keratoconus. METHODS:The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study is a long-...

journal_title：Cornea

authors： McMahon TT,Edrington TB,Szczotka-Flynn L,Olafsson HE,Davis LJ,Schechtman KB,CLEK Study Group.

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the vision-related quality of life (QOL) and satisfaction of elderly patients who underwent corneal transplantations. METHODS:Survey data using a modified version of the Visual Function Index were collected in February-March 2013 from 175 patients (age ≥65 years) of 414 elig...

journal_title：Cornea

authors： Puri S,Robinson SB,Wang J,Sikder S

更新日期：2014-02-01 00:00:00

abstract：:The fellow normal-appearing eyes of 23 patients with unilateral aphakic bullous keratopathy were examined by wide-field specular microscopy and pachymetry. All patients had: pseudophakic or aphakic bullous keratopathy in one eye; unoperated fellow eye on no medication; no other ocular disease; and no endothelial gutta...

journal_title：Cornea

authors： Roberts CW,Boruchoff SA,Kenyon KR

更新日期：1984-01-01 00:00:00