Brillouin Microscopy Visualizes Centralized Corneal Edema in Fuchs Endothelial Dystrophy.

Abstract:

PURPOSE:To investigate the feasibility of using Brillouin microscopy for assessment of corneal edema in patients with Fuchs endothelial corneal dystrophy (FECD). Brillouin microscopy analyzes the frequency shift of light inelastically scattered by naturally occurring acoustic waves in a small volume of tissue. The resulting frequency shift is a measure of the local hydromechanical properties of the tissue. METHODS:Participants were scanned using a clinical Brillouin imaging system (780 nm laser, 5 mW), and a color-coded map of the mean Brillouin shift laterally across the corneal stroma was created. RESULTS:Brillouin maps of normal subjects (n = 8) were relatively homogeneous, whereas maps of patients with FECD (n = 7) exhibited significantly reduced Brillouin shifts (unpaired t test, P < 0.001) centrally. The mean difference of 83 MHz corresponds to approximately 3.9% higher water content (percentage difference in volume fraction) in central corneas of the FECD group relative to normal subjects. The Brillouin scan of a patient with FECD 1 month after Descemet membrane endothelial keratoplasty measured a 62 MHz increase in Brillouin shift relative to the preoperative level, indicating normalization of corneal hydration. CONCLUSIONS:All patients with FECD scanned exhibited a centralized reduction in Brillouin shift, distinct from the normal subjects measured and consistent with centralized edema characterized by pachymetry. Brillouin scans revealed substantially reduced water content after Descemet membrane endothelial keratoplasty. These results suggest that Brillouin microscopy could aid treatment planning and assessment of FECD. Moreover, corneal hydration mapping may be useful in understanding fluid pump function dynamics of the cornea and developing early interventions for FECD.

journal_name

Cornea

journal_title

Cornea

authors

Eltony AM,Clouser F,Shao P,Pineda R 2nd,Yun SH

doi

10.1097/ICO.0000000000002191

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

168-171

issue

2

eissn

0277-3740

issn

1536-4798

journal_volume

39

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Bilateral epibulbar xanthomas--a case report.

    abstract:PURPOSE:To report bilateral epibulbar xanthomatous lesions in an adult with a normal serum lipid profile and no cutaneous or systemic features of a histiocytic disease. METHODS:Clinicopathologic report. RESULTS:A 44-year-old man presented with gradually enlarging yellow epibulbar masses in both eyes. The lesions had ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181a3c419

    authors: Satchi K,Loughnan MS,McKelvie PA,McNab AA

    更新日期:2010-02-01 00:00:00

  • The BioMask for treatment of corneal surface irregularities with excimer laser phototherapeutic keratectomy.

    abstract:PURPOSE:To assess the characteristics of BioMask as a potential masking agent for use with the excimer laser. METHOD:We addressed ablation rate, smoothness, ease of use, dioptric shift, treatment of standardized irregular topography, and ability of BioMask to induce dioptric change in vivo. RESULTS:BioMask ablates at...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199903000-00003

    authors: Stevens SX,Bowyer BL,Sanchez-Thorin JC,Rocha G,Young DA,Rowsey JJ

    更新日期:1999-03-01 00:00:00

  • Nevirapine-induced Stevens-Johnson syndrome in an HIV patient.

    abstract:PURPOSE:To report a case of nevirapine-induced Stevens-Johnson syndrome (SJS) misdiagnosed as viral keratitis. METHODS:A 35-year-old AIDS patient, on antiretroviral therapy (ART) with stavudine, nevirapine, and lamivudine, developed bilateral ocular congestion and irritation. He was being treated elsewhere for bilater...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31815b941b

    authors: Jain V,Shome D,Natarajan S

    更新日期:2008-04-01 00:00:00

  • Surgical Management of Limbal Dermoids Using Anterior Corneal Buttons From Descemet Stripping Automated Endothelial Keratoplasty Donor Tissue as Patch Grafts.

    abstract:PURPOSE:To assess the surgical and clinical outcomes of anterior lamellar keratoplasty using anterior corneal buttons from Descemet stripping automated endothelial keratoplasty (DSAEK) donor tissue. METHODS:Retrospective data from 8 patients with unilateral limbal dermoids, treated between February 2011 and January 20...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001021

    authors: Wu KI,Chu HS,Pai AS,Hou YC,Lin SY,Chen WL,Hu FR

    更新日期:2017-01-01 00:00:00

  • Microcomputer software applied to corneal stromal biometry.

    abstract::Here we report a new method for image analysis of the corneal stroma. To obtain the biometric characteristics of a given area, we perform three different treatments of the same image. These automated predictions closely match each parameter (length, surface area, etc.), as measured manually by a "blind investigator." ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199107000-00009

    authors: Karpouzas I,Durand JP,Keller N,Savoldelli M,Pouliquen Y

    更新日期:1991-07-01 00:00:00

  • A new nonhuman primate model of severe dry eye.

    abstract:PURPOSE:The aim of this study was to establish a new rhesus monkey model of severe dry eye. METHODS:A total of 8 rhesus monkeys were used for the study. Four monkeys had their main lacrimal gland and nictitating membrane surgically removed (group 1). Another 4 monkeys had a similar surgery with further application of ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000085

    authors: Qin Y,Tan X,Zhang Y,Jie Y,Labbe A,Pan Z

    更新日期:2014-05-01 00:00:00

  • Successful treatment of Paecilomyces lilacinus keratitis with oral posaconazole.

    abstract:PURPOSE:To report a case of successful medical treatment with oral posaconazole in refractory fungal keratitis caused by Paecilomyces lilacinus. METHODS:Case report. RESULTS:A 57-year-old male, soft contact lens wearer presented with irritation, pain, photophobia, and reduced vision. Slit-lamp examination showed a la...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000143

    authors: Arnoldner MA,Kheirkhah A,Jakobiec FA,Durand ML,Hamrah P

    更新日期:2014-07-01 00:00:00

  • High-Resolution Optical Coherence Tomography Findings of Lisch Epithelial Corneal Dystrophy.

    abstract:PURPOSE:To describe a case of Lisch epithelial corneal dystrophy (LECD) and present its unique characteristics on high-resolution optical coherence tomography (HR-OCT). METHODS:A 78-year-old man with whorled corneal epithelial opacities in the right eye was referred for the evaluation of ocular surface squamous neopla...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000722

    authors: Pole C,Sise A,Joag M,Galor A,Bermudez-Magner JA,Dubovy S,Karp CL

    更新日期:2016-03-01 00:00:00

  • Ocular morbidity associated with airbag deployment: a report of seven cases and a review of the literature.

    abstract:PURPOSE:To review ocular injuries secondary to airbag deployment that were seen in our institution and were reported in the literature. METHODS:Patients examined at our institution between 1997 and 2000 were evaluated for ocular injuries caused by airbags. A review of the medical literature using Medline was performed...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/00003226-200103000-00009

    authors: Ball DC,Bouchard CS

    更新日期:2001-03-01 00:00:00

  • Hemangiogenesis and lymphangiogenesis in corneal pathology.

    abstract:PURPOSE:We characterized the presence of hemangiogenesis (HA) and lymphangiogenesis (LA) in human corneal specimens exhibiting 13 underlying pathologies. METHODS:Human corneal specimens were obtained from consenting subjects (n = 2 or n = 3 for each pathology; total sample size, n = 35). The pathological specimens wer...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31821dd986

    authors: Tshionyi M,Shay E,Lunde E,Lin A,Han KY,Jain S,Chang JH,Azar DT

    更新日期:2012-01-01 00:00:00

  • Acanthamoeba keratitis in a 5-year-old boy without a history of contact lens usage.

    abstract:PURPOSE:This study was designed to report a case of acanthamoeba keratitis in a 5-year-old child without a history of trauma or contact lens usage. METHODS:The history, clinical presentation, diagnostic, and therapeutic approaches were reviewed. RESULTS:A 5-year-old child without any history of trauma or contact lens...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000178723.26940.74

    authors: Demirci G,Ay GM,Karabas LV,Altintas O,Tamer GS,Cağlar Y

    更新日期:2006-04-01 00:00:00

  • Treatment of Acute Corneal Hydrops With Combined Intracameral Gas and Approximation Sutures in Patients With Corneal Ectasia.

    abstract:PURPOSE:To assess the efficacy and safety of combined intracameral sulfur hexafluoride and full-thickness corneal sutures in the treatment of acute corneal hydrops (CH). METHODS:This is an uncontrolled series of cases with keratoconus (KC), keratoglobus (KG), and pellucid marginal degeneration that presented with CH o...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002155

    authors: Mohebbi M,Pilafkan H,Nabavi A,Mirghorbani M,Naderan M

    更新日期:2020-02-01 00:00:00

  • Cell Therapy of Corneal Diseases.

    abstract::Mesenchymal stem cells isolated from connective tissues are pluripotent and differentiate into phenotypes of connective tissue cell lineages (osteoblasts, chondrocytes, and adipocytes) in vitro and in vivo. They have been used to treat mouse models of connective tissue disease such as lumican-null (Lum) and mucopolysa...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0000000000001010

    authors: Kao WW,Coulson-Thomas VJ

    更新日期:2016-11-01 00:00:00

  • Intraocular lens exchange 1 week after descemet stripping automated endothelial keratoplasty.

    abstract:PURPOSE:To report a case of intraocular lens (IOL) exchange performed 1 week after Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS:Describe the clinical findings and outcome of IOL exchange in an 80-year-old man with pseudophakic bullous keratopathy and retained Artisan (Ophtec BV, Groningen, th...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181a1669e

    authors: Lapenna L,Kadyan A,Busin M

    更新日期:2010-02-01 00:00:00

  • Altered conjunctival response after contact lens-related corneal inflammation.

    abstract:PURPOSE:Corneal inflammation in overnight contact lens (CL) wear is not fully understood. We designed a masked study to examine the impact of overnight CL wear on clinical variables in subjects who had previously experienced corneal inflammatory disease. METHODS:Forty-four subjects were entered into the study: Nine su...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200307000-00010

    authors: Stapleton F,Ramachandran L,Sweeney DF,Rao G,Holden BA

    更新日期:2003-07-01 00:00:00

  • Anterior-Segment Optical Coherence Tomography and Scanning Electron Microscopy to Evaluate Corneal Epithelial Changes in Patients Undergoing Glaucoma Therapy.

    abstract:PURPOSE:To measure corneal epithelial thickness (CET) in patients with glaucoma using anterior-segment optical coherence tomography and to evaluate CET changes in relation to corneal epithelial microvilli analyzed by scanning electron microscopy (SEM). METHODS:Twenty-two eyes (16 patients) being treated with preservat...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001752

    authors: Cennamo G,Montorio D,Del Prete S,Del Prete A,Cennamo G

    更新日期:2018-12-01 00:00:00

  • Long-term clinical course of dry eye in patients with chronic graft-versus-host disease referred for eye examination.

    abstract:PURPOSE:To assess the long-term clinical course of dry eye in patients with chronic graft-versus-host disease (cGVHD). METHODS:A prospective case series of 49 patients with cGVHD was conducted. Complete history and ophthalmic examination were performed at baseline and at 36 months (range, 26-53). All patients received...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181e9b3bf

    authors: Sáles CS,Johnston LJ,Ta CN

    更新日期:2011-02-01 00:00:00

  • Use of topical bevacizumab for conjunctival intraepithelial neoplasia.

    abstract:PURPOSE:To report our experience in the treatment of intraepithelial neoplasia of the conjunctiva using topical bevacizumab. METHODS:Ten eyes of 10 patients with conjunctival neoplasia received 25 mg/mL bevacizumab topically. Changes in the lesions were documented weekly using digital photography. After topical treatm...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000194

    authors: Özcan AA,Çiloğlu E,Esen E,Şimdivar GH

    更新日期:2014-11-01 00:00:00

  • Human Corneal Endothelial Cell Assessment From Tissues Preserved in Serum-Based and Synthetic Storage Media.

    abstract:PURPOSE:To assess the difference between endothelial cells from tissues preserved in media supplemented with fetal bovine serum (FBS) and recombinant human serum albumin (rHSA). METHODS:In a donor-matched study, 48 tissues were preserved for 28 days at 31°C in Cornea Max and Cornea Syn supplemented with FBS and rHSA, ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002097

    authors: Parekh M,Ruzza A,Ponzin D,Ahmad S,Ferrari S

    更新日期:2019-11-01 00:00:00

  • Corneal Irregular Astigmatism and Curvature Changes After Small Incision Lenticule Extraction: Three-Year Follow-Up.

    abstract:PURPOSE:To evaluate the long-term changes in anterior and posterior corneal irregular astigmatism and curvatures after small incision lenticule extraction (SMILE). METHODS:Fifty eyes of 28 patients underwent SMILE for myopic astigmatism. All procedures were performed using the VisuMax® femtosecond laser. A Scheimpflug...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001532

    authors: Sideroudi H,Lazaridis A,Messerschmidt-Roth A,Labiris G,Kozobolis V,Sekundo W

    更新日期:2018-07-01 00:00:00

  • Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions.

    abstract::Specular microscopy can provide a noninvasive morphologic analysis of the corneal endothelial cell layer from subjects enrolled in clinical trials. The analysis provides a measure of the endothelial cell physiologic reserve from aging, ocular surgical procedures, pharmaceutical exposure, and general health of the corn...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0b013e31815892da

    authors: McCarey BE,Edelhauser HF,Lynn MJ

    更新日期:2008-01-01 00:00:00

  • The incidence of fungal keratitis and endophthalmitis following penetrating keratoplasty.

    abstract:PURPOSE:To determine the incidence of postkeratoplasty fungal endophthalmitis and keratitis at the New York Eye and Ear Infirmary. To determine whether there is a relationship between culture-positive corneoscleral donor material and postoperative infection. METHODS:The microbiologic records of corneoscleral donor rim...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico..0000138832.3486.70

    authors: Keyhani K,Seedor JA,Shah MK,Terraciano AJ,Ritterband DC

    更新日期:2005-04-01 00:00:00

  • Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo.

    abstract:PURPOSE:The efficacy of gene therapy using nonviral vector based on polyplex micelle has been studied against corneal neovascularization in mice. METHODS:A block copolymer, poly(ethylene glycol) (PEG)-block-polycation carrying ethylenediamine units in the side chain (PEG-b-P[Asp(DET)]), was prepared. PEG-b-P[Asp(DET)]...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318206c893

    authors: Iriyama A,Usui T,Yanagi Y,Amano S,Oba M,Miyata K,Nishiyama N,Kataoka K

    更新日期:2011-12-01 00:00:00

  • Evaluation of granular corneal dystrophy with optical coherent tomography.

    abstract:OBJECTIVE:To determine the intrastromal layer of corneal deposits in granular corneal dystrophy (GCD). DESIGN:Investigative case report. METHODS:A 32-year-old woman with bilateral decreased vision because of corneal deposits was examined with cross-sectional scans using optical coherence tomography (OCT). RESULTS:Vi...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200404000-00009

    authors: Meyer CH,Sekundo W

    更新日期:2004-04-01 00:00:00

  • Posterior amorphous corneal dystrophy: ultrasound biomicroscopy findings in two cases.

    abstract::We present two cases of posterior amorphous corneal dystrophy in members of the same family. We correlated the clinical findings with refraction, topography, and ultrasound biomicroscopy (UBM). This is the first report of UBM findings in amorphous corneal dystrophy and we describe the depth of stromal opacification me...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200203000-00020

    authors: Castelo Branco B,Chalita MR,Casanova FH,Castelo Branco AB,Allemann N,de Freitas D

    更新日期:2002-03-01 00:00:00

  • Abnormal extracellular matrix in corneas with pseudophakic bullous keratopathy.

    abstract::The present study describes biochemical and morphological differences of pseudophakic bullous keratopathy (PBK) corneas as compared with normal corneas. At the ultrastructural level, all PBK corneas studied had abnormal fibrillar material posterior to the Descemet's membrane. In addition, two of the six PBK buttons ha...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Kenney MC,Chwa M

    更新日期:1990-04-01 00:00:00

  • Corneal perforation with secondary congenital aphakia in Peters anomaly.

    abstract:PURPOSE:To describe two cases of secondary congenital aphakia in association with Peters anomaly. METHODS:Two infants were noted to have corneal opacification at birth. Each child was found to have Peters anomaly requiring corneal transplantation in 1 or both eyes. RESULTS:Each child underwent penetrating keratoplast...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000134187.19117.6a

    authors: Banning CS,Blackmon DM,Song CD,Grossniklaus HE

    更新日期:2005-01-01 00:00:00

  • In vivo and in vitro demonstration of epithelial cell-induced myofibroblast differentiation of keratocytes and an inhibitory effect by amniotic membrane.

    abstract:PURPOSE:To examine the role of epithelial cells in inducing the differentiation of keratocytes into myofibroblasts and to determine whether this effect may be inhibited by amniotic membrane matrix. METHODS:In vivo, a 9-mm diameter, partial-thickness corneal flap was created in 12 rabbit eyes (6 rabbits), which were eq...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200103000-00019

    authors: Choi TH,Tseng SC

    更新日期:2001-03-01 00:00:00

  • Survival after transplantation of corneas from a rabies-infected donor.

    abstract:PURPOSE:To examine the tissue samples of 2 corneal recipients from a rabies-infected donor for the presence of rabies to explain their survival. METHODS:Interventional case series with a review of the literature. The explanted corneal donor buttons were examined via nested reverse transcriptase polymerase chain reacti...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0b013e3181e4572a

    authors: Vetter JM,Frisch L,Drosten C,Ross RS,Roggendorf M,Wolters B,Müller T,Dick HB,Pfeiffer N

    更新日期:2011-02-01 00:00:00

  • Wavelike epitheliopathy after phacoemulsification: role of in vivo confocal microscopy.

    abstract:PURPOSE:The purpose of this report was to describe an uncommon wavelike epitheliopathy after phacoemulsification in a 59-year-old man with well-controlled diabetes mellitus. METHODS:Retrospective case report. RESULTS:A 59-year-old man with a history of well-controlled diabetes mellitus presented to us with irritation...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31804f59f3

    authors: Babu K,Narasimha Murthy K,Ramachandra Murthy K

    更新日期:2007-07-01 00:00:00