A new nonhuman primate model of severe dry eye.


PURPOSE:The aim of this study was to establish a new rhesus monkey model of severe dry eye. METHODS:A total of 8 rhesus monkeys were used for the study. Four monkeys had their main lacrimal gland and nictitating membrane surgically removed (group 1). Another 4 monkeys had a similar surgery with further application of 50% trichloroacetic acid on the bulbar conjunctiva (group 2). The ocular surface was evaluated before and after the surgery (1, 4, 8, 12, and 24 weeks) using Schirmer-1 test, corneal fluorescein staining, and the lissamine green test. Conjunctival impression cytology was also performed before and 24 weeks after the surgery. Finally, the cornea and the conjunctiva were evaluated using light microscopy. RESULTS:A significant decrease in tear secretion was observed in all operated eyes. Schirmer test data measured were ≤4 mm in all the operated eyes. Slit-lamp examination also revealed abnormal staining in all the operated eyes that remained stable until the end of the experiment. In group 2, corneal fluorescein staining and lissamine green test values were always ≥5 (max 12) and ≥4 (max 9), respectively. Impression cytology specimens of both the treated groups showed conjunctival squamous metaplasia and a decreased number of goblet cells. Under light microscopy, the corneal epithelium appeared irregular with edematous basal epithelial cells. The conjunctiva showed a decreased goblet cell density with infiltration of inflammatory cells. CONCLUSIONS:Complete removal of the principal lacrimal gland and nictitating membrane associated with the application of 50% trichloroacetic acid on the conjunctiva could induce severe dry eye in rhesus monkeys.






Qin Y,Tan X,Zhang Y,Jie Y,Labbe A,Pan Z




Has Abstract


2014-05-01 00:00:00














  • Topical treatment with 1% cyclosporine for subepithelial infiltrates secondary to adenoviral keratoconjunctivitis.

    abstract:PURPOSE:To evaluate the treatment with topical 1% cyclosporine A (CsA) in patients with subepithelial corneal infiltrates (SEIs). METHODS:We retrospectively reviewed the records of 9 patients (12 eyes) before and after the treatment with CsA 1% eyedrops twice daily. All patients had been treated with topical corticost...


    pub_type: 杂志文章


    authors: Levinger E,Slomovic A,Sansanayudh W,Bahar I,Slomovic AR

    更新日期:2010-06-01 00:00:00

  • Corneal involvement in congenital aniridia.

    abstract:PURPOSE:The purpose of this research is 2-fold. First of all, the level of keratopathy development in patients with congenital aniridia is studied. In addition, a correlation between the effects of ocular surgery on the severity of keratopathy is made. METHODS:A thorough search for the total number of patients with an...


    pub_type: 杂志文章


    authors: Edén U,Riise R,Tornqvist K

    更新日期:2010-10-01 00:00:00

  • Ocular manifestations after primary varicella infection.

    abstract:PURPOSE:To report a case of ocular manifestations after a primary varicella infection. METHODS:Review of the literature and a case report of a 10-year-old male patient with history of blurry vision and an enlarged pupil 2 months after a varicella infection. Examination revealed uveitis, interstitial keratitis, and int...


    pub_type: 杂志文章


    authors: Fernández de Castro LE,Sarraf OA,Hawthorne KM,Solomon KD,Vroman DT

    更新日期:2006-08-01 00:00:00

  • Corneal trephination with the femtosecond laser.

    abstract:PURPOSE:To evaluate the feasibility and cut quality of corneal trephination in human donor corneal tissue with the femtosecond laser. METHODS:Twelve human corneoscleral discs were inserted in an artificial anterior chamber. After corneal thickness measurement and tonometry, the cornea was mounted on a femtosecond lase...


    pub_type: 杂志文章


    authors: Meltendorf C,Schroeter J,Bug R,Kohnen T,Deller T

    更新日期:2006-10-01 00:00:00

  • Detection of herpes simplex virus type 1 in failed descemet stripping automated endothelial keratoplasty grafts.

    abstract:PURPOSE:To determine the prevalence of herpes simplex virus type 1 (HSV-1) DNA in failed Descemet membrane stripping automated endothelial keratoplasty (DSAEK) grafts. METHODS:A retrospective interventional case series of patients with DSAEK graft failure treated at the New York Eye and Ear Infirmary between January 2...


    pub_type: 杂志文章


    authors: Yin D,Huang A,Warrow D,Ritterband DC,Seedor JA,McCormick SA,Milman T

    更新日期:2013-09-01 00:00:00

  • Limbal stem cell transplantation for the treatment of subepithelial amyloidosis of the cornea (gelatinous drop-like dystrophy).

    abstract:PURPOSE:Subepithelial amyloidosis of the cornea, or gelatinous drop-like corneal dystrophy (GDD), is a severe form of corneal stromal amyloidosis predominantly found in the Japanese population. GDD causes severe visual disturbances with irritating symptoms, and keratoplasty is inevitably complicated by early recurrence...


    pub_type: 杂志文章


    authors: Shimazaki J,Shimmura S,Tsubota K

    更新日期:2002-03-01 00:00:00

  • Incidence and clinical characteristics of enterococcus keratitis.

    abstract:PURPOSE:To study the incidence, clinically relevant factors, and antibiotic sensitivity profile of cases of enterococcal keratitis presenting at the New York Eye and Ear Infirmary between January 1, 1996, and December 31, 2005. METHODS:The records of all corneal cultures submitted to the Microbiology Laboratory of the...


    pub_type: 杂志文章


    authors: Rau G,Seedor JA,Shah MK,Ritterband DC,Koplin RS

    更新日期:2008-09-01 00:00:00

  • Risk Factors for Sporadic Diffuse Lamellar Keratitis After Microkeratome Laser-Assisted In Situ Keratomileusis: A Retrospective Large Database Analysis.

    abstract:PURPOSE:To determine the factors associated with sporadic diffuse lamellar keratitis (DLK) after microkeratome laser-assisted in situ keratomileusis (LASIK). METHODS:This large database retrospective study included consecutive cases of LASIK performed between 2007 and 2016 at Care-Vision Laser Centers, Tel-Aviv, Israe...


    pub_type: 杂志文章


    authors: Segev F,Mimouni M,Sela T,Munzer G,Kaiserman I

    更新日期:2018-09-01 00:00:00

  • Intrastromal antifungal injection with secondary lamellar interface infusion for late-onset infectious keratitis after DSAEK.

    abstract:PURPOSE:The aim of this study was to report the successful medical management of 2 cases of late-onset endothelial keratoplasty-related stromal interface infections. METHODS:All cases of endothelial keratoplasty-related infections treated with intrastromal antifungal injections were compiled. The following information...


    pub_type: 杂志文章


    authors: Tu EY,Hou J

    更新日期:2014-09-01 00:00:00

  • Three decades of corneal transplantation: indications and patient characteristics.

    abstract:PURPOSE:To review the indications and patient characteristics for penetrating keratoplasty (PKP). METHODS:Retrospective review of records at the Pathology Service, Department of Ophthalmology, University of Toronto from 1964 to 1997. RESULTS:The 6,222 records were reviewed. The leading indications for PKP were regraf...


    pub_type: 杂志文章


    authors: Maeno A,Naor J,Lee HM,Hunter WS,Rootman DS

    更新日期:2000-01-01 00:00:00

  • Transplantation of corneal endothelial cells using a cell carrier device.

    abstract::Penetrating keratoplasty is currently the only treatment for corneal endothelial dysfunction. Although corneal transplantation has a high success rate, a few problems still remain, such as the limited availability of donor grafts, the change in refraction after penetrating keratoplasty, and the higher chance of immune...


    pub_type: 杂志文章


    authors: Mohay J,Lange TM,Soltau JB,Wood TO,McLaughlin BJ

    更新日期:1994-03-01 00:00:00

  • The stability of corneal topography in the post-blink interval.

    abstract:PURPOSE:Videokeratoscopes provide a wealth of information about the topography of the ocular surface. Although there have been numerous studies of the accuracy and precision of videokeratoscopes with inanimate test objects, little information exists on their precision (repeatability) for real eyes. METHODS:To investig...


    pub_type: 杂志文章


    authors: Buehren T,Collins MJ,Iskander DR,Davis B,Lingelbach B

    更新日期:2001-11-01 00:00:00

  • Persistent corneal endothelial deposits associated with rifabutin therapy for Crohn's disease.

    abstract:PURPOSE:To report a case of corneal endothelial deposits associated with rifabutin therapy for Crohn's disease. METHOD:Case report, anterior segment photography, and current literature search. RESULTS:Persistence of corneal endothelial deposits was found to occur in a 55-year-old gentleman 6 years after cessation of ...


    pub_type: 杂志文章


    authors: Williams K,Ilari L

    更新日期:2010-06-01 00:00:00

  • Corneal perforation with secondary congenital aphakia in Peters anomaly.

    abstract:PURPOSE:To describe two cases of secondary congenital aphakia in association with Peters anomaly. METHODS:Two infants were noted to have corneal opacification at birth. Each child was found to have Peters anomaly requiring corneal transplantation in 1 or both eyes. RESULTS:Each child underwent penetrating keratoplast...


    pub_type: 杂志文章


    authors: Banning CS,Blackmon DM,Song CD,Grossniklaus HE

    更新日期:2005-01-01 00:00:00

  • In vitro amoebicidal activity of propamidine and pentamidine isethionate against Acanthamoeba species and toxicity to corneal tissues.

    abstract::Effective chemotherapy for Acanthamoeba keratitis has been hampered because of the marked resistance of the parasites to a variety of antimicrobial agents. In view of the fact that topical Brolene (propamidine isethionate) and neosporin are currently considered to be the medical treatment of choice in Europe, we sough...


    pub_type: 杂志文章


    authors: Alizadeh H,Silvany RE,Meyer DR,Dougherty JM,McCulley JP

    更新日期:1997-01-01 00:00:00

  • Abnormalities of the extracellular matrix in keratoconus corneas.

    abstract:PURPOSE:To study alterations of the extracellular matrix (ECM) and basement membrane (BM) components in human keratoconus corneas. METHODS:Fifteen normal and 13 keratoconus corneas were characterized by immunofluorescence with antibodies to 23 ECM and BM components. RESULTS:Keratoconus staining patterns for posterior...


    pub_type: 杂志文章


    authors: Kenney MC,Nesburn AB,Burgeson RE,Butkowski RJ,Ljubimov AV

    更新日期:1997-05-01 00:00:00

  • The brilliant beauty of the eye: light reflex from the cornea and tear film.

    abstract:PURPOSE:Light reflex from the cornea and tear film as contributors to beautiful eyes ("eye sparkling") are reviewed. METHODS:A systematic literature review was conducted using "Purkinje-Sanson image," "corneal light reflex," "corneal topography," "corneal wavefront aberration," and "tear interference image" as search ...


    pub_type: 杂志文章,评审


    authors: Goto E

    更新日期:2006-12-01 00:00:00

  • The histopathology of the iridocorneal-endothelial syndrome.

    abstract::The iridocorneal-endothelial (ICE) syndrome is characterised clinically by a "hammered-silver" appearance of the corneal endothelium, corneal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed "ICE cells." The pu...


    pub_type: 杂志文章


    authors: Levy SG,Kirkness CM,Moss J,Ficker L,McCartney AC

    更新日期:1996-01-01 00:00:00

  • Ciprofloxacin ointment versus ciprofloxacin drops for therapy of experimental Pseudomonas keratitis.

    abstract::To compare the efficacy of ciprofloxacin hydrochloride ointment with that of ciprofloxacin drops for treatment of experimental Pseudomonas keratitis, rabbit eyes were infected by intrastromal injection of 10(3) colony-forming units (CFU) log-phase P. aeruginosa. Infected and uninfected eyes were treated with either 0....


    pub_type: 杂志文章


    authors: Hobden JA,O'Callaghan RJ,Insler MS,Hill JM

    更新日期:1993-03-01 00:00:00

  • Treatment of aniridia with Boston type I keratoprosthesis.

    abstract:PURPOSE:To report the outcomes of Boston keratoprosthesis (K-pro) type I implantation for congenital aniridia. METHODS:A retrospective review of the medical records of every patient with congenital aniridia who underwent Boston K-pro type I implantation at the University of Iowa Hospitals and Clinics from January 1, 2...


    pub_type: 杂志文章


    authors: Rixen JJ,Cohen AW,Kitzmann AS,Wagoner MD,Goins KM

    更新日期:2013-07-01 00:00:00

  • Epithelium-off corneal collagen cross-linking versus transepithelial cross-linking for pediatric keratoconus.

    abstract:PURPOSE:To compare efficiency and safety of epithelium-off corneal cross-linking (CXL) and transepithelial cross-linking (TE-CXL) in pediatric patients with progressive keratoconus. METHODS:Uncorrected and corrected visual acuity, corneal topography and pachymetry (Pentacam; Oculus Pentacam), and in vivo confocal micr...


    pub_type: 杂志文章


    authors: Magli A,Forte R,Tortori A,Capasso L,Marsico G,Piozzi E

    更新日期:2013-05-01 00:00:00

  • Ocular Manifestations of Chordin-like 1 Knockout Mice.

    abstract:PURPOSE:In humans, loss-of-function mutations in the gene encoding Chordin-like 1 (CHRDL1) cause X-linked megalocornea (MGC1), characterized by bilateral corneal enlargement, decreased corneal thickness, and increased anterior chamber depth (ACD). We sought to determine whether Chrdl1 knockout (KO) mice would recapitul...


    pub_type: 杂志文章


    authors: Chen D,Liu Y,Shu G,Chen C,Sullivan DA,Kam WR,Hann S,Fowler M,Warman ML

    更新日期:2020-09-01 00:00:00

  • Amniotic membrane transplantation in severe bacterial keratitis.

    abstract:PURPOSE:To determine whether a combination of early amniotic membrane transplantation (AMT) and early topical corticosteroid treatment could be a safe adjuvant therapy during antibacterial treatment in severe bacterial keratitis (BK) for relieving pain, avoiding iatrogenic epithelial toxicity, and allowing earlier use ...


    pub_type: 杂志文章


    authors: Gicquel JJ,Bejjani RA,Ellies P,Mercié M,Dighiero P

    更新日期:2007-01-01 00:00:00

  • Epidemiology of Ocular Surface Squamous Neoplasia in a Veterans Affairs Population.

    abstract:PURPOSE:To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population. METHODS:Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs H...


    pub_type: 杂志文章


    authors: McClellan AJ,McClellan AL,Pezon CF,Karp CL,Feuer W,Galor A

    更新日期:2013-10-01 00:00:00

  • Recurrent keratoconus.

    abstract::Keratoconus is a progressive, noninflammatory, nonvascular axial corneal ectasia, with unclear etiology and pathogenesis. It has a prevalence of 50-230 per 100,000 and is a bilateral disorder in up to 90% of cases. The onset of keratoconus is usually at puberty and progresses over 10-20 years producing an irregular my...


    pub_type: 杂志文章


    authors: Bechrakis N,Blom ML,Stark WJ,Green WR

    更新日期:1994-01-01 00:00:00

  • A Novel Epidemiological Approach to Geographically Mapping Population Dry Eye Disease in the United States Through Google Trends.

    abstract:PURPOSE:Our study fills the spatiotemporal gaps in dry eye disease (DED) epidemiology by using Google Trends as a novel epidemiological tool for geographically mapping DED in relation to environmental risk factors. METHODS:We used Google Trends to extract DED-related queries estimating users' intent from 2004 to 2019 ...


    pub_type: 杂志文章


    authors: Azzam DB,Nag N,Tran J,Chen L,Visnagra K,Marshall K,Wade M

    更新日期:2020-11-06 00:00:00

  • Amniotic membrane transplantation and fibrin glue in the management of corneal ulcers and perforations: a review of 33 cases.

    abstract:PURPOSE:To evaluate the efficacy of amniotic membrane in corneal ulcers refractive to conventional treatment and amniotic membrane with fibrin glue in corneal perforations. METHODS:Amniotic membrane transplantation (AMT) was performed in 33 eyes from 32 patients for corneal ulcers refractive to conventional treatment....


    pub_type: 杂志文章


    authors: Hick S,Demers PE,Brunette I,La C,Mabon M,Duchesne B

    更新日期:2005-05-01 00:00:00

  • Comparison of corneal endothelial image analysis by Konan SP8000 noncontact and Bio-Optics Bambi systems.

    abstract:PURPOSE:Compare corneal endothelial image analysis by Konan SP8000 and Bio-Optics Bambi image-analysis systems. METHODS:Corneal endothelial images from 98 individuals (191 eyes), ranging in age from 4 to 87 years, with a normal slit-lamp examination and no history of ocular trauma, intraocular surgery, or intraocular ...


    pub_type: 杂志文章


    authors: Benetz BA,Diaconu E,Bowlin SJ,Oak SS,Laing RA,Lass JH

    更新日期:1999-01-01 00:00:00

  • Expression of phosphorylated heat shock protein 27 during corneal epithelial wound healing.

    abstract:PURPOSE:The 27-kDa heat shock protein (HSP27) has been implicated in wound healing in multiple tissues. We investigated the expression and localization of phosphorylated HSP27 during epithelial wound healing in the murine cornea. METHODS:Corneas of 8- to 10-week-old C57BL6 mice were wounded by epithelial debridement (...


    pub_type: 杂志文章


    authors: Jain S,De la Cruz J,Kang E,Kojima T,Chang JH,Kim JY

    更新日期:2012-07-01 00:00:00

  • Contralateral Autologous Corneal Transplantation Experience in Mexico City.

    abstract:PURPOSE:The aim of this study is to expand the limited knowledge regarding autologous contralateral penetrating keratoplasty. METHODS:We report the retrospective outcomes of patients who received autokeratoplasty and contralateral opaque corneas in the donor eye at a tertiary care ophthalmology hospital in Mexico City...


    pub_type: 杂志文章


    authors: Perez-Balbuena AL,Ancona-Lezama D,Delgado-Pelayo S,Martinez JD

    更新日期:2017-01-01 00:00:00