Abstract:
PURPOSE:The aim of this study was to establish a new rhesus monkey model of severe dry eye. METHODS:A total of 8 rhesus monkeys were used for the study. Four monkeys had their main lacrimal gland and nictitating membrane surgically removed (group 1). Another 4 monkeys had a similar surgery with further application of 50% trichloroacetic acid on the bulbar conjunctiva (group 2). The ocular surface was evaluated before and after the surgery (1, 4, 8, 12, and 24 weeks) using Schirmer-1 test, corneal fluorescein staining, and the lissamine green test. Conjunctival impression cytology was also performed before and 24 weeks after the surgery. Finally, the cornea and the conjunctiva were evaluated using light microscopy. RESULTS:A significant decrease in tear secretion was observed in all operated eyes. Schirmer test data measured were ≤4 mm in all the operated eyes. Slit-lamp examination also revealed abnormal staining in all the operated eyes that remained stable until the end of the experiment. In group 2, corneal fluorescein staining and lissamine green test values were always ≥5 (max 12) and ≥4 (max 9), respectively. Impression cytology specimens of both the treated groups showed conjunctival squamous metaplasia and a decreased number of goblet cells. Under light microscopy, the corneal epithelium appeared irregular with edematous basal epithelial cells. The conjunctiva showed a decreased goblet cell density with infiltration of inflammatory cells. CONCLUSIONS:Complete removal of the principal lacrimal gland and nictitating membrane associated with the application of 50% trichloroacetic acid on the conjunctiva could induce severe dry eye in rhesus monkeys.
journal_name
Corneajournal_title
Corneaauthors
Qin Y,Tan X,Zhang Y,Jie Y,Labbe A,Pan Zdoi
10.1097/ICO.0000000000000085subject
Has Abstractpub_date
2014-05-01 00:00:00pages
510-7issue
5eissn
0277-3740issn
1536-4798journal_volume
33pub_type
杂志文章相关文献
CORNEA文献大全abstract:PURPOSE:To assess the endothelial cell loss after cataract extraction using a fluid-based system and compare it with conventional ultrasound. METHODS:A total of 46 eyes of 23 patients with up to 3+ bilateral cataract were included. The first eye was randomized to either fluid-based system or conventional ultrasound, a...
journal_title:Cornea
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ico.0000226366.64796.20
更新日期:2006-10-01 00:00:00
abstract::The purpose of this study was to determine whether corneal epithelial defects and epitheliopathy in patients with unilateral dysfunction of the ophthalmic division of the trigeminal nerve (neurotrophic keratitis) is associated with reduced aqueous tear production. Sensation of the skin, cornea, and nasal mucosa, aqueo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199603000-00005
更新日期:1996-03-01 00:00:00
abstract:PURPOSE:To report a case of direct contact xylene-related vacuolar keratopathy. METHODS:Interventional case report and review of the literature. RESULTS:Xylene keratopathy is a distinct clinical entity characterized by significantly decreased visual acuity, increased corneal thickness, and the presence of corneal epi...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/00003226-200301000-00023
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:To report a case of keratitis and corneal melt after conductive keratoplasty (CK) enhancement. METHOD:Case report. RESULTS:A 52-year-old woman with emmetropic presbyopia had undergone previous CK for monovision and underwent CK enhancement 4 years later. Postoperatively, she was managed with ketorolac trometh...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181ef6ec7
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:Microbiological contamination is a common cause for elimination of organ-cultured donor corneas. The aims of the present study were to analyze contamination rates and identify risk factors for contamination. METHODS:Retrospectively, the contamination rates of 4546 organ-cultured corneas and the causative speci...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31825d586b
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To introduce an improved technique of pterygium surgery and to compare postoperative results between this technique and previous techniques. METHODS:In a retrospective survey, the records of 216 consecutive eyes with primary pterygium that underwent surgery by three different techniques were reviewed. The new ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200110000-00006
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:To evaluate the thickness and depth of lamina cribrosa (LC) in the optic nerve head region of the eyes in patients with nonglaucomatous keratoconus and to compare the thickness and depth with those of age-matched controls. METHODS:This was a cross-sectional, observational study comprising 45 patients with kera...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001379
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to report a case of a central Descemet membrane detachment after heavy silicone oil removal from the anterior chamber. METHODS:This is a case report of a patient operated with scleral buckling and heavy silicone oil implantation for recurrent retinal detachment. In the patient's follo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000056
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:To investigate the morphological changes of corneal epithelium and subbasal nerves by in vivo confocal microscopy in patients with ocular surface disease (OSD) treated with cord blood serum (CBS) eye drops. METHODS:Twenty patients with OSD (mean age 61.1 ± 12.6 years) were included in this prospective 1-arm st...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001257
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To report intraocular lens (IOL) power calculation in 2 eyes that were highly undercorrected by previous myopic automated lamellar keratoplasty (ALK). METHODS:A 35-year-old man underwent bilateral myopic ALK, which caused high residual myopia (-9.0 -4.0 x 171 and -9.5 -4.5 x 74). The patient then underwent cat...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31817c41fc
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:To report a 16-year-old woman who had peripheral keratitis as a presenting sign of microscopic polyangiitis (MPA), which rapidly progressed to acute renal failure. METHOD:Case report. RESULTS:The patient's vasculitis was diagnosed by renal biopsy, which was evaluated with histologic, immunofluorescence, and e...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200107000-00016
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:The normal cornea is devoid of blood and lymphatic vessels but can become vascularized secondary to a variety of corneal diseases and surgical manipulations. Whereas corneal (hem)angiogenesis, i.e., the outgrowth of new blood vessels from preexisting limbal vessels, is obvious both clinically and histologically...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/00003226-200304000-00021
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:Surgical management of advanced pellucid marginal degeneration is challenging. To correct both corneal thinning and induced corneal astigmatism, we propose a modified intrastromal lamellar sclero-keratoplasty. METHODS:Corneal thinning was mapped using perioperative optical coherence tomography (OCT). Then thro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000813
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:One of the most disturbing trends in recent years is the growth of resistant strains of bacteria with the simultaneous dearth of new antimicrobial agents. Thus, new antimicrobial agents for the use on the ocular surface are needed. METHODS:We synthesized a variety of ionic liquid compounds, which possess 2 pos...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31823f0a86
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:To report a case of corneal infection with Chrysosporium parvum, a filamentous fungus usually associated with pulmonary infections. METHODS:A 43-year-old Saudi man had a corneal stromal infiltrate and perforation of his left eye. He was treated with a therapeutic penetrating keratoplasty and topical and system...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:PURPOSE:To describe the effect of the corneal asphericity and toricity on the map patterns and best fit sphere (BFS) characteristics in elevation topography. METHODS:The corneal surface was modeled as a biconic surface of principal radii and asphericity values of r1 and r2 and Q1 and Q2, respectively. The apex of the ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181fb4fa7
更新日期:2011-05-01 00:00:00
abstract::Persistent donor corneal epithelial defects following penetrating keratoplasty may lead to graft failure. We herein describe a method for providing corneal protection using a temporary suture tarsorrhaphy. This technique is simple and completely reversible, and it allows continued observation and instillation of topic...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199103000-00005
更新日期:1991-03-01 00:00:00
abstract:PURPOSE:To evaluate changes in the anterior chamber of eyes that have undergone Descemet membrane endothelial keratoplasty (DMEK) and to identify factors that affect these changes. METHODS:This retrospective study included 25 pseudophakic eyes of 25 patients who underwent DMEK. We determined the preoperative and posto...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002535
更新日期:2020-09-29 00:00:00
abstract:PURPOSE:To investigate the regulation of matrix metalloproteinase (MMP)-3 and MMP-13 expression over time and in the presence of cyclosporine A (CsA) in primary cultured human pterygium fibroblasts. We also examined the effects of CsA on cultured human pterygium fibroblasts. METHODS:Primary cultured human pterygium fi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000477
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To characterize the clinical presentation of limbal stem cell deficiency (LSCD) associated with glaucoma surgeries. METHODS:This is a retrospective cross-sectional study of patients with LSCD and glaucoma who presented to the Stein Eye Institute at the University of California, Los Angeles, between 2009 and 20...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002249
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To investigate the changes of meibomian gland (MG) and tear film stability in subjects with eyelid tattoos. METHODS:Forty female subjects were recruited. Ten subjects had eyelid tattoos and 30 subjects did not (control group). Tear film break-up time (TBUT) measurement and fluorescein staining were performed t...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000452
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:The purpose of this study was to relate lysosomal enzyme activities in corneal storage media to the outcome of the transplanted corneas. METHODS:Corneal storage media from 358 transplanted corneas were frozen at -70 degrees C and kept for enzyme analysis. Corneas were stored in K-Sol (28), CSM (35), Dexsol (80...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract:PURPOSE:To present a novel apparatus for simulating the anterior and posterior segment pressure dynamics involved in executing Descemet membrane endothelial keratoplasty (DMEK) surgery when using a chamber-shallowing technique. METHODS:An artificial anterior chamber (AAC), 18-mm trephine, latex glove, two 3-mL syringe...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001435
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To report 5-year outcomes of ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) with a central graft thickness intended to be <100 μm. METHODS:This retrospective, consecutive, interventional case series included 354 eyes with endothelial decompensation due to various causes (Fuchs endot...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001999
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:To review the incidence, distribution, current trends, and resistance patterns of bacterial keratitis isolates in Toronto over the past 16 years. METHODS:Microbiology records of suspected bacterial keratitis that underwent a diagnostic corneal scraping and cultures from January 1, 2000, through December 31, 20...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001390
更新日期:2017-12-01 00:00:00
abstract::Absorbable intracanalicular collagen implants were placed in both canaliculi of one eye of nine human volunteers. The other eye served as a control. Twenty-four hours later 2% sodium fluorescein was placed into both conjunctival sacs. Serial corneal fluorescein concentrations were measured with a scanning ocular fluor...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199111000-00009
更新日期:1991-11-01 00:00:00
abstract:PURPOSE:To compare the effect of a 3- and 5-minute intraoperative application of topical mitomycin C 0.02% on the recurrence of pterygium. METHODS:A comparative, prospective clinical design was used. The study population consisted of 134 consecutive patients with unilateral primary advanced pterygium (growth of 3 mm o...
journal_title:Cornea
pub_type: 临床试验,杂志文章
doi:10.1097/00003226-200303000-00003
更新日期:2003-03-01 00:00:00
abstract:PURPOSE:To report 2 cases of corneal perforation associated with a persistent epithelial defect (PED), which were treated with eye drops containing the fibronectin-derived peptide PHSRN (Pro-His-Ser-Arg-Asn). METHODS:A 67-year-old man and a 58-year-old man presented with corneal perforation associated with a PED cause...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000592
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:To describe whether subconjunctival bevacizumab decreases corneal neovascularization in patients with ocular surface inflammatory diseases. METHODS:The study is a retrospective case series that includes 8 eyes of 7 patients with corneal neovascularization. Patients received 1-3 injections of 2.5 mg subconjunct...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31817786ad
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of intraoperative mitomycin-C in excision of ocular surface neoplasia for prevention of recurrence. METHODS:Seven patients (eight eyes), three men and four women, aged 56 to 87 years (mean, 73.8 years), with lesions suspicious for corneal or conjunctival neoplasia, were operated on bet...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200201000-00004
更新日期:2002-01-01 00:00:00