Use of topical bevacizumab for conjunctival intraepithelial neoplasia.

Abstract:

PURPOSE:To report our experience in the treatment of intraepithelial neoplasia of the conjunctiva using topical bevacizumab. METHODS:Ten eyes of 10 patients with conjunctival neoplasia received 25 mg/mL bevacizumab topically. Changes in the lesions were documented weekly using digital photography. After topical treatment, excisional biopsy was performed. RESULTS:The mean age of the patients was 60.5 ± 12 (33-77) years. The mean duration of topical treatment was 7.8 ± 1.3 (5-14) weeks. The size and vascularity of the tumors reduced weekly. All patients underwent excisional biopsy, cryotherapy, and amnion membrane transplantation. The histopathologic diagnosis of the lesions was carcinoma in situ. No recurrence was observed during the follow-up of patients for 6 months. CONCLUSIONS:Topical bevacizumab is an effective treatment to reduce the tumor size before surgery and may be a good alternative for adjuvant therapy of conjunctival neoplasms.

journal_name

Cornea

journal_title

Cornea

authors

Özcan AA,Çiloğlu E,Esen E,Şimdivar GH

doi

10.1097/ICO.0000000000000194

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1205-9

issue

11

eissn

0277-3740

issn

1536-4798

journal_volume

33

pub_type

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