Effect of fourth-generation fluoroquinolones on the healing rate of corneal erosions in an animal model.

Abstract:

PURPOSE:To compare the rate of epithelial healing of corneal erosion in an animal model with 2 commercial formulations of fourth-generation fluoroquinolones: 0.3% gatifloxacin and 0.5% moxifloxacin. METHODS:Corneal erosions, 6 mm in diameter, were created in 28 rabbit eyes. The rabbits were randomized to receive topical gatifloxacin, moxifloxacin, or nonpreserved saline. Drops were administered every 15 minutes for 1 hour, then hourly for 3 hours, and then 4 times daily until the erosion reepithelialized. Eyes were examined with fluorescein drops and photographed every 12 hours with a cobalt blue-filtered light. When reepithelialization was observed, the rabbits were euthanized, and their eyes were enucleated for histopathologic evaluation. RESULTS:Reepithelialization of the corneal erosions was fastest in the saline-treated eyes (57.3 +/- 8 hours), followed by moxifloxacin (62.7 +/- 11.7 hours) and gatifloxacin (66 +/- 8.5 hours). These differences in the time to closure of the erosions among the 3 groups were not statistically significant. Although significant differences were found among the healing progression curves when all 3 groups were compared (P = 0.042), the difference between the 2 antibiotic-treated groups was not significant. CONCLUSIONS:Only slight differences in epithelial healing rates were found between the gatifloxacin-, moxifloxacin-, and saline-treated groups, suggesting that the 2 fluoroquinolones may have an equivalent role as prophylactic treatment of trauma- or surgery-induced corneal erosions.

journal_name

Cornea

journal_title

Cornea

authors

Barequet IS,Habot-Wilner Z,Lavinsky F,Ziv H,Belkin M,Rosner M

doi

10.1097/ICO.0b013e318041f08e

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

606-9

issue

5

eissn

0277-3740

issn

1536-4798

pii

00003226-200706000-00019

journal_volume

26

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Trends in the etiology of infectious corneal ulcers at the F. I. Proctor Foundation.

    abstract:OBJECTIVE:We analyzed laboratory results from corneal ulcers seen from 1976 to 1999 at the Francis I. Proctor Foundation, a referral center in San Francisco, to determine the relative frequencies of pathogens and to analyze for trends in frequencies of the most common pathogens. The results were compared with a previou...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200405000-00009

    authors: Varaprasathan G,Miller K,Lietman T,Whitcher JP,Cevallos V,Okumoto M,Margolis TP,Yinghui M,Cunningham ET Jr

    更新日期:2004-05-01 00:00:00

  • A safe Nd:YAG retroprosthetic membrane removal technique for keratoprosthesis.

    abstract:PURPOSE:To describe a technique for Nd:YAG laser photodiscission of retroprosthetic membrane (RPM) in keratoprosthesis patients that minimizes damage to the optic. METHODS:Prospective review of Boston type I keratoprosthesis patients at 1 site who received Nd:YAG treatment for RPM from 2005 to 2009. Outcomes were base...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181cda001

    authors: Chak G,Aquavella JV

    更新日期:2010-10-01 00:00:00

  • Adenoviral ocular isolates demonstrate serotype-dependent differences in in vitro infectivity titers and clinical course.

    abstract::The purpose of this study was to evaluate clinical ocular adenoviral isolates for differences among and within serotypes with respect to in vitro infectivity titers and clinical course. The study design included a retrospective chart review and the determination of in vitro infectivity titers (TCID90s) of 90 clinical ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199507000-00007

    authors: Roba LA,Kowalski RP,Gordon AT,Romanowski EG,Gordon YJ

    更新日期:1995-07-01 00:00:00

  • Eccentrically Punched Descemet Membrane Endothelial Keratoplasty Grafts Expand the Descemet Membrane Endothelial Keratoplasty Donor Pool: One Eye Bank's Reappraisal of the Central Clear Zone Convention.

    abstract:PURPOSE:To ascertain whether offsetting the Descemet membrane endothelial keratoplasty (DMEK) punch can expand the donor pool in conjunction with prepunched and preloaded services by recapturing the corneas otherwise excluded by the conventional central clear zone criteria. METHODS:In this retrospective review of corn...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002348

    authors: Kornberg DL,Prabhu S,Sales CS,Williams RS,Clover J,Tran KD

    更新日期:2020-10-01 00:00:00

  • A new nonhuman primate model of severe dry eye.

    abstract:PURPOSE:The aim of this study was to establish a new rhesus monkey model of severe dry eye. METHODS:A total of 8 rhesus monkeys were used for the study. Four monkeys had their main lacrimal gland and nictitating membrane surgically removed (group 1). Another 4 monkeys had a similar surgery with further application of ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000085

    authors: Qin Y,Tan X,Zhang Y,Jie Y,Labbe A,Pan Z

    更新日期:2014-05-01 00:00:00

  • Ocular surface squamous neoplasia: a survey of changes in the standard of care from 2003 to 2012.

    abstract:PURPOSE:To evaluate the current standard of care of ophthalmologists who are likely to encounter ocular surface squamous neoplasia (OSSN) in their practices and to compare this with data gathered in 2003. METHODS:Invitations to a web-based survey were sent to members of the Ocular Microbiology and Immunology Group. In...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182a6ea6c

    authors: Adler E,Turner JR,Stone DU

    更新日期:2013-12-01 00:00:00

  • Descemet membrane detachment after heavy silicone oil removal from the anterior chamber.

    abstract:PURPOSE:The aim of this study was to report a case of a central Descemet membrane detachment after heavy silicone oil removal from the anterior chamber. METHODS:This is a case report of a patient operated with scleral buckling and heavy silicone oil implantation for recurrent retinal detachment. In the patient's follo...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000056

    authors: Kymionis GD,Tsoulnaras KI,Xanthopoulou NA,Klados NE,Tsilimbaris MK

    更新日期:2014-03-01 00:00:00

  • Comparison of corneal surface higher-order aberrations after endothelial keratoplasty, femtosecond laser-assisted keratoplasty, and conventional penetrating keratoplasty.

    abstract:PURPOSE:To evaluate and compare corneal higher-order aberrations (HOAs) after Descemet stripping automated endothelial keratoplasty (DSAEK), femtosecond laser-assisted penetrating keratoplasty (FLAK), and conventional penetrating keratoplasty (PKP). METHODS:A retrospective comparison of consecutive surgical series of ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182151df2

    authors: Chamberlain W,Omid N,Lin A,Farid M,Gaster RN,Steinert RF

    更新日期:2012-01-01 00:00:00

  • Effect of Histocompatibility Y Antigen Matching on Graft Survival in Primary Penetrating Keratoplasty.

    abstract:PURPOSE:To investigate the influence of histocompatibility Y (H-Y) antigen matching on corneal graft survival in primary penetrating keratoplasty (PK). METHODS:Medical records of patients who underwent primary PK at Seoul National University Bundang Hospital between June 2005 and October 2015 were retrospectively anal...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001394

    authors: Kim MJ,Kim JH,Jeon HS,Wee WR,Hyon JY

    更新日期:2018-01-01 00:00:00

  • In vivo and in vitro demonstration of epithelial cell-induced myofibroblast differentiation of keratocytes and an inhibitory effect by amniotic membrane.

    abstract:PURPOSE:To examine the role of epithelial cells in inducing the differentiation of keratocytes into myofibroblasts and to determine whether this effect may be inhibited by amniotic membrane matrix. METHODS:In vivo, a 9-mm diameter, partial-thickness corneal flap was created in 12 rabbit eyes (6 rabbits), which were eq...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200103000-00019

    authors: Choi TH,Tseng SC

    更新日期:2001-03-01 00:00:00

  • Outcomes of Flap Lift Laser In Situ Keratomileusis Enhancements in a Large Patient Population: Does Application of a Bandage Contact Lens Affect Incidence of Epithelial Ingrowth?

    abstract:PURPOSE:To compare the incidence of corneal epithelial ingrowth (EIG) and the visual outcomes of enhancement with laser in situ keratomileusis (LASIK) by flap lift when a bandage soft contact lens (CL) was fitted after the procedure and when it was not. METHODS:This is a multicenter, retrospective, interventional case...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ICO.0000000000002132

    authors: Ortega-Usobiaga J,Baviera-Sabater J,Llovet-Osuna F,González-López F,Bilbao-Calabuig R,Llovet-Rausell A,Beltrán-Sanz J

    更新日期:2019-12-01 00:00:00

  • Double-Line Reflection Pattern as a Simple Method to Determine Graft Orientation of Descemet Membrane Endothelial Keratoplasty.

    abstract:PURPOSE:To describe a simple finding, consisting of a double-line reflection from the graft inside the anterior chamber, that can be used to determine the correct donor tissue orientation in Descemet membrane endothelial keratoplasty: which we would like to call Berrospi's sign. METHODS:Evaluation of the presence of l...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001889

    authors: Berrospi RD,Galvis V,Bhogal M,Tello A

    更新日期:2019-06-01 00:00:00

  • Recovery time of an optimally secreting meibomian gland.

    abstract:PURPOSE:To investigate the times for an optimally secreting meibomian gland (OSMG) to be drained of available liquid secretion, to recover with expressible liquid secretion, and then to be redrained. METHODS:Twelve subjects with no dry eye symptoms and mean age 21.3 +/- 1.9 years were recruited. Lipid layer thickness ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31818913b4

    authors: Blackie CA,Korb DR

    更新日期:2009-04-01 00:00:00

  • Acanthamoeba keratitis: a parasite on the rise.

    abstract:PURPOSE:To report a recent significant increase of the number of patients diagnosed with Acanthamoeba keratitis (AK) at Wills Eye Hospital between 2004 and 2005. To determine the risk factors, clinical characteristics, treatments, and outcomes of patients with AK. METHODS:Retrospective consecutive case series of 20 ey...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31805b7e63

    authors: Thebpatiphat N,Hammersmith KM,Rocha FN,Rapuano CJ,Ayres BD,Laibson PR,Eagle RC Jr,Cohen EJ

    更新日期:2007-07-01 00:00:00

  • Impression cytologic analysis after corneal collagen cross-linking using riboflavin and ultraviolet-A light in the treatment of keratoconus.

    abstract:PURPOSE:To report impression cytologic (IC) results after corneal cross-linking (CXL) using riboflavin and ultraviolet-A light in the treatment of keratoconus and compare the data with those from a group of subjects with the same disease. METHODS:Forty eyes were distributed into 2 groups: patients in group 1 underwent...

    journal_title:Cornea

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ICO.0b013e3181d4f91a

    authors: Renesto Ada C,Barros Jde N,Campos M

    更新日期:2010-10-01 00:00:00

  • Anatomical Changes in the Anterior Chamber Volume After Descemet Membrane Endothelial Keratoplasty.

    abstract:PURPOSE:To evaluate changes in the anterior chamber of eyes that have undergone Descemet membrane endothelial keratoplasty (DMEK) and to identify factors that affect these changes. METHODS:This retrospective study included 25 pseudophakic eyes of 25 patients who underwent DMEK. We determined the preoperative and posto...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002535

    authors: Onouchi H,Hayashi T,Shimizu T,Matsuzawa A,Suzuki Y,Kato N

    更新日期:2020-09-29 00:00:00

  • Descemet's stripping automated endothelial keratoplasty (DSAEK) using corneal donor tissue not acceptable for use in penetrating keratoplasty as a result of anterior stromal scars, pterygia, and previous corneal refractive surgical procedures.

    abstract:PURPOSE:The purpose of this study was to evaluate outcomes of Descemet's stripping automated endothelial keratoplasty (DSAEK) using anterior stromal flawed (ASF) donor corneas that were unsuitable for use in full-thickness penetrating keratoplasty as a result of stromal scars, pterygia, or previous corneal refractive s...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318199f8d7

    authors: Phillips PM,Terry MA,Shamie N,Chen ES,Hoar KL,Stoeger C,Friend DJ,Saad HA

    更新日期:2009-09-01 00:00:00

  • Donor-related risk factors and preoperative recipient-related risk factors for graft failure.

    abstract:PURPOSE:The aim of this study was to evaluate the outcome of penetrating keratoplasties, at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany, using organ-cultured donor corneas and to identify preoperative risk factors, which may influence the event of graft failure. METHODS:In this study, 3...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000225

    authors: Yu AL,Kaiser M,Schaumberger M,Messmer E,Kook D,Welge-Lussen U

    更新日期:2014-11-01 00:00:00

  • Corneal infections after implantation of intracorneal ring segments.

    abstract:PURPOSE:To report risk factors, clinical course, and outcome in patients with infectious keratitis following implantation of intracorneal ring segments (ICRS). METHODS:The records of 8 patients with culture-proven infectious keratitis after ICRS (Ferrara or Intacs) implantation were retrospectively reviewed. Age, gend...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000126434.95325.24

    authors: Hofling-Lima AL,Branco BC,Romano AC,Campos MQ,Moreira H,Miranda D,Kwitko S,de Freitas D,Casanova FH,Sartori M,Schor P,Souza LB

    更新日期:2004-08-01 00:00:00

  • Epidemiology of Ocular Surface Squamous Neoplasia in a Veterans Affairs Population.

    abstract:PURPOSE:To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population. METHODS:Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs H...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31829e3c80

    authors: McClellan AJ,McClellan AL,Pezon CF,Karp CL,Feuer W,Galor A

    更新日期:2013-10-01 00:00:00

  • Donor eyes. A comparison of characteristics and outcomes for Eye Bank and local tissue.

    abstract::The Corneal Recipient Registry was begun in 1985 to collect information on all recipients of corneal grafts in the province of Ontario, Canada, and on the donors providing tissue. While most of the tissue is handled by the Eye Bank of Canada (Ontario Division), ophthalmologists in centers away from the Eye Bank often ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Chipman ML,Willett P,Basu PK,Wolf A

    更新日期:1989-01-01 00:00:00

  • Intraoperative mitomycin C 0.02% for pterygium: effect of duration of application on recurrence rate.

    abstract:PURPOSE:To compare the effect of a 3- and 5-minute intraoperative application of topical mitomycin C 0.02% on the recurrence of pterygium. METHODS:A comparative, prospective clinical design was used. The study population consisted of 134 consecutive patients with unilateral primary advanced pterygium (growth of 3 mm o...

    journal_title:Cornea

    pub_type: 临床试验,杂志文章

    doi:10.1097/00003226-200303000-00003

    authors: Avisar R,Gaton DD,Loya N,Appel I,Weinberger D

    更新日期:2003-03-01 00:00:00

  • Gross factors in treatment of nonhealing corneal ulcers and recurrent erosions.

    abstract::Epidermal growth factor (EGF) is known to promote corneal epithelial wound healing in experimental scrape and keratectomy models. We studied its efficacy in treating alkali-burned epithelial ulceration. EGF induced hyperplasia and cell proliferation to resurface the denuded and denatured corneal stroma, but it did not...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Singh G,Foster CS

    更新日期:1989-01-01 00:00:00

  • Corneal involvement in congenital aniridia.

    abstract:PURPOSE:The purpose of this research is 2-fold. First of all, the level of keratopathy development in patients with congenital aniridia is studied. In addition, a correlation between the effects of ocular surgery on the severity of keratopathy is made. METHODS:A thorough search for the total number of patients with an...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181d20493

    authors: Edén U,Riise R,Tornqvist K

    更新日期:2010-10-01 00:00:00

  • The brilliant beauty of the eye: light reflex from the cornea and tear film.

    abstract:PURPOSE:Light reflex from the cornea and tear film as contributors to beautiful eyes ("eye sparkling") are reviewed. METHODS:A systematic literature review was conducted using "Purkinje-Sanson image," "corneal light reflex," "corneal topography," "corneal wavefront aberration," and "tear interference image" as search ...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/01.ico.0000247219.18295.5e

    authors: Goto E

    更新日期:2006-12-01 00:00:00

  • Corneal perforation with secondary congenital aphakia in Peters anomaly.

    abstract:PURPOSE:To describe two cases of secondary congenital aphakia in association with Peters anomaly. METHODS:Two infants were noted to have corneal opacification at birth. Each child was found to have Peters anomaly requiring corneal transplantation in 1 or both eyes. RESULTS:Each child underwent penetrating keratoplast...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000134187.19117.6a

    authors: Banning CS,Blackmon DM,Song CD,Grossniklaus HE

    更新日期:2005-01-01 00:00:00

  • Posterior amorphous corneal dystrophy. An ultrastructural study of a variant with histopathological features of an endothelial dystrophy.

    abstract::Posterior amorphous corneal dystrophy (PACD) is a rare autosomal-dominant disease, generally classified with the pre-Descemet's dystrophies. It is characterized by deep stromal corneal opacification, flat corneas with low keratometry values, and central thinning. To our knowledge, only one previous ultrastructural stu...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Roth SI,Mittelman D,Stock EL

    更新日期:1992-03-01 00:00:00

  • Corneal steepening after epikeratoplasty.

    abstract::Four patients had removal of their epikeratoplasty lenticules for unsatisfactory visual results. This was out of a consecutive series of 36 eyes. Three eyes were myopic and one was aphakic. In all four eyes, there was significant corneal steepening with an average increase in myopia of 2.4 diopters and an average incr...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Nirankari VS

    更新日期:1989-12-01 00:00:00

  • Standards for modified osteoodontokeratoprosthesis (OOKP) surgery according to Strampelli and Falcinelli: the Rome-Vienna Protocol.

    abstract:PURPOSE:To establish a time-proven "gold standard" in modified osteoodontokeratoprosthesis (OOKP) surgery. METHODS:The OOKP is the procedure of choice for restoring sight in patients with corneal blindness caused by end-stage ocular surface disease not amenable to penetrating keratoplasty. Members of the OOKP Study Gr...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000157401.81408.62

    authors: Hille K,Grabner G,Liu C,Colliardo P,Falcinelli G,Taloni M,Falcinelli G

    更新日期:2005-11-01 00:00:00

  • White-to-white corneal diameter in the Tehran Eye Study.

    abstract:PURPOSE:To determine the mean corneal diameter and its determinants in the population of Tehran. METHODS:From the Tehran Eye Study participants who were sampled through a stratified cluster approach, those in the first 4 municipality districts of Tehran were selected, and after applying the inclusion and exclusion cri...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ICO.0b013e3181a9d0a9

    authors: Hashemi H,KhabazKhoob M,Yazdani K,Mehravaran S,Mohammad K,Fotouhi A

    更新日期:2010-01-01 00:00:00