Gross factors in treatment of nonhealing corneal ulcers and recurrent erosions.

Abstract:

:Epidermal growth factor (EGF) is known to promote corneal epithelial wound healing in experimental scrape and keratectomy models. We studied its efficacy in treating alkali-burned epithelial ulceration. EGF induced hyperplasia and cell proliferation to resurface the denuded and denatured corneal stroma, but it did not prevent recurrent erosions. A combination of EGF with fibronectin (Fn) was noted to enhance epithelial defect closure after alkali burns of the cornea and was seen to prevent recurrent erosions. Histopathologic examination of these corneas revealed marked leukocytic infiltration of the alkali-burned corneal stroma. To find ways to retard this inflammatory response, we studied the role of topical steroids and their efficacy when used with EGF, Fn, and laminin (Ln) in the management of alkali-burned corneas. Use of steroids decreased the incidence of recurrent erosions and corneal perforations. Histologically, steroids markedly decreased the leukocytic infiltration of stromal tissue, thereby retarding the collagenolysis. Topical steroids used with EGF and fibronectin were seen to promote epithelial wound closure and to prevent recurrent erosions in alkali-burned corneas. Combinations of EGF, fibronectin, and steroids may have a place in the treatment of clinical corneal alkali burns.

journal_name

Cornea

journal_title

Cornea

authors

Singh G,Foster CS

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

45-53

issue

1

eissn

0277-3740

issn

1536-4798

journal_volume

8

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Intracameral moxifloxacin: in vitro safety on human ocular cells.

    abstract:PURPOSE:The fourth-generation fluoroquinolone, moxifloxacin, covers most gram-positive and gram-negative isolates causing endophthalmitis. It is safe and effective for systemic and topical use, but only limited data are available on prophylactic intracameral administration to prevent endophthalmitis. This study uses a ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318191447b

    authors: Kernt M,Neubauer AS,Liegl RG,Lackerbauer CA,Eibl KH,Alge CS,Ulbig MW,A AK

    更新日期:2009-06-01 00:00:00

  • In vivo and in vitro demonstration of epithelial cell-induced myofibroblast differentiation of keratocytes and an inhibitory effect by amniotic membrane.

    abstract:PURPOSE:To examine the role of epithelial cells in inducing the differentiation of keratocytes into myofibroblasts and to determine whether this effect may be inhibited by amniotic membrane matrix. METHODS:In vivo, a 9-mm diameter, partial-thickness corneal flap was created in 12 rabbit eyes (6 rabbits), which were eq...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200103000-00019

    authors: Choi TH,Tseng SC

    更新日期:2001-03-01 00:00:00

  • Corneal topography after ocular rubbing.

    abstract:PURPOSE:To examine the immediate effect of ocular rubbing on corneal topography. METHODS:Corneal topography and analysis were performed before, immediately after, and 5 minutes after eyelid rubbing in 29 volunteers without ocular disease. RESULTS:The surface regularity index increased from a baseline of 0.24 to 0.91 ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200211000-00004

    authors: Mansour AM,Haddad RS

    更新日期:2002-11-01 00:00:00

  • The influence of age on the refractive index of the human corneal stroma resected using a mechanical microkeratome.

    abstract:PURPOSE:To measure the refractive index (RI) of the human corneal stroma in vivo using an objective Abbé refractometer (VCH-1) and to determine if RI of the stroma is related to age. METHODS:The VCH-1 was calibrated against a standard subjective Abbé refractometer using 7 randomly selected turbid semiliquid media. VCH...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31821008d5

    authors: Patel S,Alió JL,Amparo F,Rodriguez-Prats JL

    更新日期:2011-12-01 00:00:00

  • Novel noncontact meibography with anterior segment optical coherence tomography: Hosik meibography.

    abstract:PURPOSE:To present a novel noncontact meibography system with anterior segment optical coherence tomography (OCT), which is widely used in clinics for the anterior segment (cornea, anterior chamber angle, etc.), and compare the results with preexisting infrared meibography. METHODS:This research was carried out at the...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318247b2fd

    authors: Hwang HS,Park CW,Joo CK

    更新日期:2013-01-01 00:00:00

  • Amniotic membrane transplantation in severe bacterial keratitis.

    abstract:PURPOSE:To determine whether a combination of early amniotic membrane transplantation (AMT) and early topical corticosteroid treatment could be a safe adjuvant therapy during antibacterial treatment in severe bacterial keratitis (BK) for relieving pain, avoiding iatrogenic epithelial toxicity, and allowing earlier use ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31802b28df

    authors: Gicquel JJ,Bejjani RA,Ellies P,Mercié M,Dighiero P

    更新日期:2007-01-01 00:00:00

  • Anterior-Segment Optical Coherence Tomography and Scanning Electron Microscopy to Evaluate Corneal Epithelial Changes in Patients Undergoing Glaucoma Therapy.

    abstract:PURPOSE:To measure corneal epithelial thickness (CET) in patients with glaucoma using anterior-segment optical coherence tomography and to evaluate CET changes in relation to corneal epithelial microvilli analyzed by scanning electron microscopy (SEM). METHODS:Twenty-two eyes (16 patients) being treated with preservat...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001752

    authors: Cennamo G,Montorio D,Del Prete S,Del Prete A,Cennamo G

    更新日期:2018-12-01 00:00:00

  • Corneal steepening after epikeratoplasty.

    abstract::Four patients had removal of their epikeratoplasty lenticules for unsatisfactory visual results. This was out of a consecutive series of 36 eyes. Three eyes were myopic and one was aphakic. In all four eyes, there was significant corneal steepening with an average increase in myopia of 2.4 diopters and an average incr...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Nirankari VS

    更新日期:1989-12-01 00:00:00

  • Dry Eye Assessment in Patients With Vitiligo.

    abstract:PURPOSE:To evaluate tear osmolarity and tear film parameters in patients with vitiligo. METHODS:A total of 25 eyes of 25 patients with vitiligo with periocular involvement (group 1), 30 eyes of 30 patients with vitiligo without periocular involvement (group 2), and 20 eyes of 20 controls (group 3) were evaluated using...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001469

    authors: Erdur SK,Aydin R,Balevi A,Ozsutcu M,Kocabora MS

    更新日期:2018-04-01 00:00:00

  • Superficial hypertrophic dendriform epitheliopathy post-keratoplasty.

    abstract:PURPOSE:To describe a distinct and unusual superficial dendriform keratopathy that can be seen in postkeratoplasty eyes. METHOD:Three Caucasian women in their sixth decade of life were referred to the Corneal and External Disease Service at the University of California, Davis, and underwent penetrating keratoplasty fo...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Mannis MJ,Garcia-Ferrer FJ,Davitt S

    更新日期:1998-05-01 00:00:00

  • Cyclosporine for Dry Eye Associated With Nivolumab: A Case Progressing to Corneal Perforation.

    abstract:PURPOSE:To present the clinical outcome of 2 cases of severe dry eye associated with Nivolumab, with 1 case progressing to corneal perforation. DESIGN:Case report. CASE 1:: A 58-year-old man with metastatic melanoma was referred for the management of severe bilateral dry eyes after undergoing his sixth cycle of Nivol...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000724

    authors: Nguyen AT,Elia M,Materin MA,Sznol M,Chow J

    更新日期:2016-03-01 00:00:00

  • Method for expressing clinical and statistical significance of ocular and corneal wave front error aberrations.

    abstract:PURPOSE:The significance of ocular or corneal aberrations may be subject to misinterpretation whenever eyes with different pupil sizes or the application of different Zernike expansion orders are compared. A method is shown that uses simple mathematical interpolation techniques based on normal data to rapidly determine...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318221ce7d

    authors: Smolek MK

    更新日期:2012-03-01 00:00:00

  • Topical interferon alpha-2a treatment of herpes simplex keratitis resistant to multiple antiviral medications in an immunosuppressed patient.

    abstract::The treatment of herpes simplex keratitis has ranged from simple debridement to the use of prototypic antiviral agents specific to the herpes family, such as acyclovir. The various treatment modalities for dendritic keratitis, for the most part, have been effective. However, in recent years numerous reports of antivir...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199505000-00017

    authors: Minkovitz JB,Pepose JS

    更新日期:1995-05-01 00:00:00

  • Albumin in the cornea is oxidized by hydrogen peroxide.

    abstract::The action of hydrogen peroxide on soluble proteins of the rat cornea has been evaluated. Two major corneal proteins are found to be oxidized by 10 mM hydrogen peroxide. Protein sequence and antibody recognition has shown one of the proteins to be albumin. Treatment of pure rat or human albumin with hydrogen peroxide ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199211000-00014

    authors: Zhu L,Crouch RK

    更新日期:1992-11-01 00:00:00

  • New graft inserter for descemet stripping automated endothelial keratoplasty.

    abstract:PURPOSE:The aim of this study was to introduce a newly developed graft inserter for Descemet stripping automated endothelial keratoplasty, which can be readily used with 1 hand, and to examine endothelial cell loss (ECL) after graft insertion using this new inserter in an ex vivo rabbit model. METHODS:Rabbit corneal g...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000073

    authors: Toyama T,Honda N,Usui T,Amano S

    更新日期:2014-04-01 00:00:00

  • Use of Corneas From Septic Donors for Descemet Membrane Endothelial Keratoplasty.

    abstract:PURPOSE:To evaluate the suitability of corneas from septic donors for transplantation by analyzing the discard rate in the eye bank and the clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) using organ-cultured corneal grafts from septic versus nonseptic donors. METHODS:This retrospective study inc...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002443

    authors: Vasiliauskaitė I,de Jong M,Quilendrino R,van der Wees J,Oellerich S,Melles GRJ

    更新日期:2021-01-01 00:00:00

  • Potentiation by cyclic AMP of the stimulatory effect of epidermal growth factor on corneal epithelial migration.

    abstract:PURPOSE:To provide insight into the mechanism by which epidermal growth factor (EGF) stimulates corneal epithelial migration, we investigated the possible interaction between EGF and cyclic AMP (cAMP) signaling pathways during epithelial migration with an organ culture system for the rabbit cornea. METHODS:Rabbit corn...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200305000-00014

    authors: Nakamura M,Nishida T

    更新日期:2003-05-01 00:00:00

  • Topical autologous platelet-rich plasma eyedrops for acute corneal chemical injury.

    abstract:PURPOSE:Evaluation of efficacy of autologous platelet-rich plasma eyedrops as an adjunct to standard medical treatment as compared with standard medical treatment with artificial tears in acute ocular chemical injury. METHODS:Twenty eyes with grade III to grade V chemical injury were randomly assigned to 2 groups. Gro...

    journal_title:Cornea

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ICO.0b013e3182114661

    authors: Panda A,Jain M,Vanathi M,Velpandian T,Khokhar S,Dada T

    更新日期:2012-09-01 00:00:00

  • Comparison of Oculus Pentacam and Stratus optical coherence tomography for measurement of central corneal thickness.

    abstract:PURPOSE:Measurement of central corneal thickness (CCT) plays an essential role in the diagnosis and treatment of many ocular diseases. In this study, we aimed to compare the CCT measurements obtained using the Scheimpflug system (Pentacam; Oculus, Inc) with a retinal optical coherence tomography device (Stratus OCT; Ca...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31820128a4

    authors: Ceylan OM,Turk A,Erdurman C,Mumcuoglu T,Erdem U,Gokce G,Dagli S

    更新日期:2011-06-01 00:00:00

  • Descemet's stripping automated endothelial keratoplasty (DSAEK) using corneal donor tissue not acceptable for use in penetrating keratoplasty as a result of anterior stromal scars, pterygia, and previous corneal refractive surgical procedures.

    abstract:PURPOSE:The purpose of this study was to evaluate outcomes of Descemet's stripping automated endothelial keratoplasty (DSAEK) using anterior stromal flawed (ASF) donor corneas that were unsuitable for use in full-thickness penetrating keratoplasty as a result of stromal scars, pterygia, or previous corneal refractive s...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318199f8d7

    authors: Phillips PM,Terry MA,Shamie N,Chen ES,Hoar KL,Stoeger C,Friend DJ,Saad HA

    更新日期:2009-09-01 00:00:00

  • Effect of a Mediterranean dietary pattern and vitamin D levels on Dry Eye syndrome.

    abstract:PURPOSE:The aim of this study was to evaluate the association between a Mediterranean dietary pattern (MeDi) and Vitamin D levels on dry eye syndrome (DES). METHODS:This was a cross-sectional study. Male patients seen in the Miami Veterans Affairs eye clinic with normal eyelid, corneal, and conjunctival anatomy were r...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000089

    authors: Galor A,Gardener H,Pouyeh B,Feuer W,Florez H

    更新日期:2014-05-01 00:00:00

  • Expression of Peroxiredoxin 2 and Vascular Endothelial Growth Factor Receptor 2 in Pterygium.

    abstract:PURPOSE:The expression of peroxiredoxin 2 and vascular endothelial growth factor receptor 2 (VEGFR2) was detected in pterygium to investigate whether they are involved in the pathogenesis or recurrence of pterygium and to evaluate the association between peroxiredoxin 2 and VEGFR2 in pterygium. METHODS:Ten normal bulb...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001213

    authors: Wang Y,Lin J,Chen L,Wang L,Hao P,Han R,Ying M,Li X

    更新日期:2017-07-01 00:00:00

  • Five-Year Outcomes of Ultrathin Descemet Stripping Automated Endothelial Keratoplasty.

    abstract:PURPOSE:To report 5-year outcomes of ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) with a central graft thickness intended to be <100 μm. METHODS:This retrospective, consecutive, interventional case series included 354 eyes with endothelial decompensation due to various causes (Fuchs endot...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001999

    authors: Madi S,Leon P,Nahum Y,DʼAngelo S,Giannaccare G,Beltz J,Busin M

    更新日期:2019-09-01 00:00:00

  • Use of impression cytology to demonstrate a retrovirus in AIDS patients with cytomegalovirus retinitis.

    abstract::Utilizing transmission electron microscopy, the authors describe results obtained from cellulose acetate impressions of the bulbar conjunctiva in acquired immunodeficiency syndrome patients with cytomegalovirus (CMV) retinitis. Particles consistent with a retrovirus were isolated, but no CMV particles were demonstrate...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199111000-00008

    authors: Pastor SA,Shuster AR,Miller MM,Lam KW

    更新日期:1991-11-01 00:00:00

  • Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis.

    abstract:PURPOSE:Using CJLAT, a chimeric herpes simplex virus (HSV-1) that produces a high incidence of herpes stromal keratitis (HSK) in latently infected rabbits, and in vivo confocal microscopy (CM), we characterized the cellular events that precede the development of HSK. METHODS:Thirty days after infection, in vivo CM was...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000666

    authors: Jester JV,Morishige N,BenMohamed L,Brown DJ,Osorio N,Hsiang C,Perng GC,Jones C,Wechsler SL

    更新日期:2016-01-01 00:00:00

  • Secondary localized amyloidosis of the cornea associated with tertiary syphilis.

    abstract::Secondary corneal amyloidosis is a rare finding and only 17 cases have been reported in the literature. A case of unilateral secondary localized corneal amyloidosis is presented in a patient with bilateral interstitial keratitis and other stigmata of tertiary syphilis. ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Hill JC,Maske R,Bowen RM

    更新日期:1990-04-01 00:00:00

  • Riboflavin/ultraviolet a crosslinking of the paracentral cornea.

    abstract:PURPOSE:The depth of corneal crosslinking (CXL) does not seem homogeneous within the treatment area but shows a reduction toward the periphery of the cornea. This study was undertaken to investigate this reduction effect and to look for possible solutions. METHODS:Ten corneas were investigated by means of an optical c...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318269059b

    authors: Koller T,Schumacher S,Fankhauser F 2nd,Seiler T

    更新日期:2013-02-01 00:00:00

  • Fibrin glue-assisted augmented amniotic membrane transplantation for the treatment of large noninfectious corneal perforations.

    abstract:PURPOSE:To evaluate and report the efficacy of fibrin glue (FG)-assisted augmented amniotic membrane transplantation (AMT) in patients with large corneal perforations. METHODS:In a retrospective case series, 10 patients with corneal perforations more than 2 mm in diameter were treated with "FG-assisted augmented AMT."...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181861c54

    authors: Kim HK,Park HS

    更新日期:2009-02-01 00:00:00

  • HLA-A,B,C, and HLA-DR antigens and dendritic cells in fresh and organ culture preserved corneas.

    abstract::Fresh and organ-culture preserved human corneas were examined for HLA-A,B,C (class I) and HLA-DR (class II) histocompatibility antigens using mouse monoclonal antibodies and an indirect immunofluorescence technique. HLA-A,B,C antigens were detected on epithelial cells and on keratocytes, but not on endothelial cells i...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Pels E,van der Gaag R

    更新日期:1984-01-01 00:00:00

  • Functional Morphology of the Lipid Layer of the Tear Film.

    abstract::Meibomian glands secrete the oily layer of the tear film, which prevents excessive evaporation of tear fluid. Dysfunction of meibomian glands is not only one of the causes of evaporative dry eye but also one of the main causes of entire dry eye. To understand the pathophysiology of meibomian gland dysfunction, it is i...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0000000000001367

    authors: Arita R,Fukuoka S,Morishige N

    更新日期:2017-11-01 00:00:00