Abstract:
PURPOSE:The p63 gene has been identified as a marker of epithelial stem cells. Because pterygium may arise through an expansion of the proliferative capacity of the conjunctiva, we sought to document the expression of p63 in normal conjunctiva and pterygium specimens. METHODS:Immunostaining for p63 expression was performed on 10 pairs of pterygium and normal conjunctiva using a monoclonal antibody directed against human p63. RESULTS:Immunopositive reactions were seen in all samples. Levels of p63-positive cells were not statistically different between pterygium and normal conjunctivae (P = 0.7). CONCLUSION:These results strongly support previous studies that indicate that pterygium arises as a result of incorrect control of cellular apoptosis rather than from an increase in proliferative capacity.
journal_name
Corneajournal_title
Corneaauthors
Sakoonwatanyoo P,Tan DT,Smith DRdoi
10.1097/00003226-200401000-00011subject
Has Abstractpub_date
2004-01-01 00:00:00pages
67-70issue
1eissn
0277-3740issn
1536-4798journal_volume
23pub_type
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