Expression of p63 in pterygium and normal conjunctiva.

Abstract:

PURPOSE:The p63 gene has been identified as a marker of epithelial stem cells. Because pterygium may arise through an expansion of the proliferative capacity of the conjunctiva, we sought to document the expression of p63 in normal conjunctiva and pterygium specimens. METHODS:Immunostaining for p63 expression was performed on 10 pairs of pterygium and normal conjunctiva using a monoclonal antibody directed against human p63. RESULTS:Immunopositive reactions were seen in all samples. Levels of p63-positive cells were not statistically different between pterygium and normal conjunctivae (P = 0.7). CONCLUSION:These results strongly support previous studies that indicate that pterygium arises as a result of incorrect control of cellular apoptosis rather than from an increase in proliferative capacity.

journal_name

Cornea

journal_title

Cornea

authors

Sakoonwatanyoo P,Tan DT,Smith DR

doi

10.1097/00003226-200401000-00011

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

67-70

issue

1

eissn

0277-3740

issn

1536-4798

journal_volume

23

pub_type

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